Dasatinib-Induced Hypopigmentation in Pediatric Patient with Chronic Myeloid Leukemia: A Case Report and Review of the Literature
Dasatinib is an oral second-generation multitarget tyrosine-kinase inhibitor (TKI) that is efficacious in treating imatinib-resistant chronic myeloid leukemia (CML) or intolerant cases. Noncutaneous adverse effects with dasatinib are well known in the literature, most commonly cytopenias and fluid r...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Case Reports in Dermatological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2018/4062431 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832552355038494720 |
|---|---|
| author | Bader Alharbi Samer Alamri Ahmed Mahdi Siham Marghalani |
| author_facet | Bader Alharbi Samer Alamri Ahmed Mahdi Siham Marghalani |
| author_sort | Bader Alharbi |
| collection | DOAJ |
| description | Dasatinib is an oral second-generation multitarget tyrosine-kinase inhibitor (TKI) that is efficacious in treating imatinib-resistant chronic myeloid leukemia (CML) or intolerant cases. Noncutaneous adverse effects with dasatinib are well known in the literature, most commonly cytopenias and fluid retention, while pigmentary abnormalities have rarely been reported. We report the case of a 12-year-old male known case of CML, who presented to dermatology clinic approximately 2 years after initiating dasatinib treatment, with new-onset hypopigmentation of his upper limb, upper chest, and both knees of six months’ duration. |
| format | Article |
| id | doaj-art-4ef948b7c5dc4ad99c1e9390e661976d |
| institution | Kabale University |
| issn | 2090-6463 2090-6471 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Dermatological Medicine |
| spelling | doaj-art-4ef948b7c5dc4ad99c1e9390e661976d2025-02-03T05:58:52ZengWileyCase Reports in Dermatological Medicine2090-64632090-64712018-01-01201810.1155/2018/40624314062431Dasatinib-Induced Hypopigmentation in Pediatric Patient with Chronic Myeloid Leukemia: A Case Report and Review of the LiteratureBader Alharbi0Samer Alamri1Ahmed Mahdi2Siham Marghalani3King Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, P.O. Box 9515, Jeddah 21423, Saudi ArabiaKing Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, P.O. Box 9515, Jeddah 21423, Saudi ArabiaKing Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, P.O. Box 9515, Jeddah 21423, Saudi ArabiaKing Abdullah International Medical Research Center, King Saud bin Abdulaziz University for Health Sciences, P.O. Box 9515, Jeddah 21423, Saudi ArabiaDasatinib is an oral second-generation multitarget tyrosine-kinase inhibitor (TKI) that is efficacious in treating imatinib-resistant chronic myeloid leukemia (CML) or intolerant cases. Noncutaneous adverse effects with dasatinib are well known in the literature, most commonly cytopenias and fluid retention, while pigmentary abnormalities have rarely been reported. We report the case of a 12-year-old male known case of CML, who presented to dermatology clinic approximately 2 years after initiating dasatinib treatment, with new-onset hypopigmentation of his upper limb, upper chest, and both knees of six months’ duration.http://dx.doi.org/10.1155/2018/4062431 |
| spellingShingle | Bader Alharbi Samer Alamri Ahmed Mahdi Siham Marghalani Dasatinib-Induced Hypopigmentation in Pediatric Patient with Chronic Myeloid Leukemia: A Case Report and Review of the Literature Case Reports in Dermatological Medicine |
| title | Dasatinib-Induced Hypopigmentation in Pediatric Patient with Chronic Myeloid Leukemia: A Case Report and Review of the Literature |
| title_full | Dasatinib-Induced Hypopigmentation in Pediatric Patient with Chronic Myeloid Leukemia: A Case Report and Review of the Literature |
| title_fullStr | Dasatinib-Induced Hypopigmentation in Pediatric Patient with Chronic Myeloid Leukemia: A Case Report and Review of the Literature |
| title_full_unstemmed | Dasatinib-Induced Hypopigmentation in Pediatric Patient with Chronic Myeloid Leukemia: A Case Report and Review of the Literature |
| title_short | Dasatinib-Induced Hypopigmentation in Pediatric Patient with Chronic Myeloid Leukemia: A Case Report and Review of the Literature |
| title_sort | dasatinib induced hypopigmentation in pediatric patient with chronic myeloid leukemia a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2018/4062431 |
| work_keys_str_mv | AT baderalharbi dasatinibinducedhypopigmentationinpediatricpatientwithchronicmyeloidleukemiaacasereportandreviewoftheliterature AT sameralamri dasatinibinducedhypopigmentationinpediatricpatientwithchronicmyeloidleukemiaacasereportandreviewoftheliterature AT ahmedmahdi dasatinibinducedhypopigmentationinpediatricpatientwithchronicmyeloidleukemiaacasereportandreviewoftheliterature AT sihammarghalani dasatinibinducedhypopigmentationinpediatricpatientwithchronicmyeloidleukemiaacasereportandreviewoftheliterature |