Primary vaccination with low dose live dengue 1 virus generates a proinflammatory, multifunctional T cell response in humans.

Primary vaccination with low dose live dengue 1 virus generates a proinflammatory, multifunctional T cell response in humans.

The four dengue virus serotypes (DENV-1-DENV-4) have a large impact on global health, causing 50-100 million cases of dengue fever annually. Herein, we describe the first kinetic T cell response to a low-dose DENV-1 vaccination study (10 PFU) in humans. Using flow cytometry, we found that proinflamm...

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Bibliographic Details
Main Authors: Janet C Lindow, Nathan Borochoff-Porte, Anna P Durbin, Stephen S Whitehead, Kelly A Fimlaid, Janice Y Bunn, Beth D Kirkpatrick
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS Neglected Tropical Diseases
Online Access:https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0001742&type=printable
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