Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats
The effects of tamoxifen (TAM) on anxiety and depression-like behavior in ovariectomized (OVX) and naïve female rats were investigated. The animals were divided into Sham-TAM, OVX-TAM, Sham and OVX groups. Tamoxifen (1 mg/kg) was administered for 4 weeks. In the forced swimming test, the immobility...
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Thieme Revinter Publicações
2015-02-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000200132&lng=en&tlng=en |
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| author | Hamid Azizi-Malekabadi Masoume Pourganji Hoda Zabihi Mohsen Saeedjalali Mahmoud Hosseini |
| author_facet | Hamid Azizi-Malekabadi Masoume Pourganji Hoda Zabihi Mohsen Saeedjalali Mahmoud Hosseini |
| author_sort | Hamid Azizi-Malekabadi |
| collection | DOAJ |
| description | The effects of tamoxifen (TAM) on anxiety and depression-like behavior in ovariectomized (OVX) and naïve female rats were investigated. The animals were divided into Sham-TAM, OVX-TAM, Sham and OVX groups. Tamoxifen (1 mg/kg) was administered for 4 weeks. In the forced swimming test, the immobility times in the OVX and Sham-TAM groups were higher than in the Sham group. In the open field, the numbers of central crossings in the OVX and Sham-TAM groups were lower than the number in the Sham group, and the number of peripheral crossings in the OVX group was lower than the number in the Sham group. In the elevated plus maze, the numbers of entries to the open arm among the animals in the Sham-TAM and OVX groups were lower than the number in the Sham group, while the number of entries to the open arm in the OVX-TAM group was higher than the number in the OVX group. It was shown that deletion of ovarian hormones induced anxiety and depression-like behavior. Administration of tamoxifen in naïve rats led to anxiety and depression-like behavior that was comparable with the effects of ovarian hormone deletion. It can be suggested that tamoxifen antagonizes the effects of ovarian hormones. It also seems that tamoxifen has anxiolytic effects on ovariectomized rats. |
| format | Article |
| id | doaj-art-4ede71e5ef514011b74d4375b6316cbb |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2015-02-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-4ede71e5ef514011b74d4375b6316cbb2025-08-20T02:05:35ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272015-02-0173213213910.1590/0004-282X20140221S0004-282X2015000200132Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in ratsHamid Azizi-MalekabadiMasoume PourganjiHoda ZabihiMohsen SaeedjalaliMahmoud HosseiniThe effects of tamoxifen (TAM) on anxiety and depression-like behavior in ovariectomized (OVX) and naïve female rats were investigated. The animals were divided into Sham-TAM, OVX-TAM, Sham and OVX groups. Tamoxifen (1 mg/kg) was administered for 4 weeks. In the forced swimming test, the immobility times in the OVX and Sham-TAM groups were higher than in the Sham group. In the open field, the numbers of central crossings in the OVX and Sham-TAM groups were lower than the number in the Sham group, and the number of peripheral crossings in the OVX group was lower than the number in the Sham group. In the elevated plus maze, the numbers of entries to the open arm among the animals in the Sham-TAM and OVX groups were lower than the number in the Sham group, while the number of entries to the open arm in the OVX-TAM group was higher than the number in the OVX group. It was shown that deletion of ovarian hormones induced anxiety and depression-like behavior. Administration of tamoxifen in naïve rats led to anxiety and depression-like behavior that was comparable with the effects of ovarian hormone deletion. It can be suggested that tamoxifen antagonizes the effects of ovarian hormones. It also seems that tamoxifen has anxiolytic effects on ovariectomized rats.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000200132&lng=en&tlng=enratoooforectomiatamoxifenodepressãoteste de natação forçadacampo abertolabirinto elevado |
| spellingShingle | Hamid Azizi-Malekabadi Masoume Pourganji Hoda Zabihi Mohsen Saeedjalali Mahmoud Hosseini Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats Arquivos de Neuro-Psiquiatria rato ooforectomia tamoxifeno depressão teste de natação forçada campo aberto labirinto elevado |
| title | Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats |
| title_full | Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats |
| title_fullStr | Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats |
| title_full_unstemmed | Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats |
| title_short | Tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression-like behavior in rats |
| title_sort | tamoxifen antagonizes the effects of ovarian hormones to induce anxiety and depression like behavior in rats |
| topic | rato ooforectomia tamoxifeno depressão teste de natação forçada campo aberto labirinto elevado |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2015000200132&lng=en&tlng=en |
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