Case report: Musculoskeletal metastastic inflammatory myofibroblastic tumor (IMT) treated by sequential ALK-TKI with longterm response
Inflammatory myofibroblastic tumors (IMTs) are known to be associated with rearrangements of the anaplastic lymphoma kinase (ALK) gene. The treatment of this type of tumor includes systemic therapies such as chemotherapies or anti-inflammatories; in recent years, targeted anti-ALK therapies have eme...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1505257/full |
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| author | Thomas Cochin Sabine Noal Dinu Stefan Damien Bodet Jérémie Rouger Marine Dorbeau Zoé Neviere |
| author_facet | Thomas Cochin Sabine Noal Dinu Stefan Damien Bodet Jérémie Rouger Marine Dorbeau Zoé Neviere |
| author_sort | Thomas Cochin |
| collection | DOAJ |
| description | Inflammatory myofibroblastic tumors (IMTs) are known to be associated with rearrangements of the anaplastic lymphoma kinase (ALK) gene. The treatment of this type of tumor includes systemic therapies such as chemotherapies or anti-inflammatories; in recent years, targeted anti-ALK therapies have emerged and became the standard of care in ALK rearranged patients. We aimed to present a rare case of musculoskeletal IMT with ALK rearrangement, characterized by metastatic evolution and enhanced responses to sequential treatment with all ALK-TKI. We have outlined a potential treatment pathway involving sequential ALK-TKI targeted therapies and successive local interventions to control the cancer. |
| format | Article |
| id | doaj-art-4ed80405c0954a4f96e6d598a772c5be |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-4ed80405c0954a4f96e6d598a772c5be2025-01-27T06:40:25ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.15052571505257Case report: Musculoskeletal metastastic inflammatory myofibroblastic tumor (IMT) treated by sequential ALK-TKI with longterm responseThomas Cochin0Sabine Noal1Dinu Stefan2Damien Bodet3Jérémie Rouger4Marine Dorbeau5Zoé Neviere6Department of Radiation Oncology, Centre François Baclesse, Caen, FranceDepartment of Sarcoma Oncology, Centre François Baclesse, Caen, FranceDepartment of Radiation Oncology, Centre François Baclesse, Caen, FranceDepartment of Pediatry Oncology, Centre Hospitalier Universitaire, Caen, FranceDepartment of Pediatry Oncology, Centre Hospitalier Universitaire, Caen, FranceDepartment of Pathology, Centre François Baclesse, Caen, FranceDepartment of Sarcoma Oncology, Centre François Baclesse, Caen, FranceInflammatory myofibroblastic tumors (IMTs) are known to be associated with rearrangements of the anaplastic lymphoma kinase (ALK) gene. The treatment of this type of tumor includes systemic therapies such as chemotherapies or anti-inflammatories; in recent years, targeted anti-ALK therapies have emerged and became the standard of care in ALK rearranged patients. We aimed to present a rare case of musculoskeletal IMT with ALK rearrangement, characterized by metastatic evolution and enhanced responses to sequential treatment with all ALK-TKI. We have outlined a potential treatment pathway involving sequential ALK-TKI targeted therapies and successive local interventions to control the cancer.https://www.frontiersin.org/articles/10.3389/fonc.2024.1505257/fullinflammatory myofibroblastic tumorcrizotinibsequential treatment ALK-TKIpediatricALK inhibitor |
| spellingShingle | Thomas Cochin Sabine Noal Dinu Stefan Damien Bodet Jérémie Rouger Marine Dorbeau Zoé Neviere Case report: Musculoskeletal metastastic inflammatory myofibroblastic tumor (IMT) treated by sequential ALK-TKI with longterm response Frontiers in Oncology inflammatory myofibroblastic tumor crizotinib sequential treatment ALK-TKI pediatric ALK inhibitor |
| title | Case report: Musculoskeletal metastastic inflammatory myofibroblastic tumor (IMT) treated by sequential ALK-TKI with longterm response |
| title_full | Case report: Musculoskeletal metastastic inflammatory myofibroblastic tumor (IMT) treated by sequential ALK-TKI with longterm response |
| title_fullStr | Case report: Musculoskeletal metastastic inflammatory myofibroblastic tumor (IMT) treated by sequential ALK-TKI with longterm response |
| title_full_unstemmed | Case report: Musculoskeletal metastastic inflammatory myofibroblastic tumor (IMT) treated by sequential ALK-TKI with longterm response |
| title_short | Case report: Musculoskeletal metastastic inflammatory myofibroblastic tumor (IMT) treated by sequential ALK-TKI with longterm response |
| title_sort | case report musculoskeletal metastastic inflammatory myofibroblastic tumor imt treated by sequential alk tki with longterm response |
| topic | inflammatory myofibroblastic tumor crizotinib sequential treatment ALK-TKI pediatric ALK inhibitor |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1505257/full |
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