Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation
The cellular response to the extracellular matrix (ECM) microenvironment mediated by integrin adhesion is of fundamental importance, in both developmental and pathological processes. In particular, mechanotransduction is of growing importance in groundbreaking cellular models such as induced pluripo...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2019/8203950 |
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| _version_ | 1832566125655752704 |
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| author | Rosaria Santoro Gianluca Lorenzo Perrucci Aoife Gowran Giulio Pompilio |
| author_facet | Rosaria Santoro Gianluca Lorenzo Perrucci Aoife Gowran Giulio Pompilio |
| author_sort | Rosaria Santoro |
| collection | DOAJ |
| description | The cellular response to the extracellular matrix (ECM) microenvironment mediated by integrin adhesion is of fundamental importance, in both developmental and pathological processes. In particular, mechanotransduction is of growing importance in groundbreaking cellular models such as induced pluripotent stem cells (iPSC), since this process may strongly influence cell fate and, thus, augment the precision of differentiation into specific cell types, e.g., cardiomyocytes. The decryption of the cellular machinery starting from ECM sensing to iPSC differentiation calls for new in vitro methods. Conveniently, engineered biomaterials activating controlled integrin-mediated responses through chemical, physical, and geometrical designs are key to resolving this issue and could foster clinical translation of optimized iPSC-based technology. This review introduces the main integrin-dependent mechanisms and signalling pathways involved in mechanotransduction. Special consideration is given to the integrin-iPSC linkage signalling chain in the cardiovascular field, focusing on biomaterial-based in vitro models to evaluate the relevance of this process in iPSC differentiation into cardiomyocytes. |
| format | Article |
| id | doaj-art-4ed6375a6f8b4af8a9a21e40a0a3681c |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-4ed6375a6f8b4af8a9a21e40a0a3681c2025-02-03T01:04:57ZengWileyStem Cells International1687-966X1687-96782019-01-01201910.1155/2019/82039508203950Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte DifferentiationRosaria Santoro0Gianluca Lorenzo Perrucci1Aoife Gowran2Giulio Pompilio3Unità di Biologia Vascolare e Medicina Rigenerativa, Centro Cardiologico Monzino IRCCS, via Carlo Parea 4, Milan, ItalyUnità di Biologia Vascolare e Medicina Rigenerativa, Centro Cardiologico Monzino IRCCS, via Carlo Parea 4, Milan, ItalyUnità di Biologia Vascolare e Medicina Rigenerativa, Centro Cardiologico Monzino IRCCS, via Carlo Parea 4, Milan, ItalyUnità di Biologia Vascolare e Medicina Rigenerativa, Centro Cardiologico Monzino IRCCS, via Carlo Parea 4, Milan, ItalyThe cellular response to the extracellular matrix (ECM) microenvironment mediated by integrin adhesion is of fundamental importance, in both developmental and pathological processes. In particular, mechanotransduction is of growing importance in groundbreaking cellular models such as induced pluripotent stem cells (iPSC), since this process may strongly influence cell fate and, thus, augment the precision of differentiation into specific cell types, e.g., cardiomyocytes. The decryption of the cellular machinery starting from ECM sensing to iPSC differentiation calls for new in vitro methods. Conveniently, engineered biomaterials activating controlled integrin-mediated responses through chemical, physical, and geometrical designs are key to resolving this issue and could foster clinical translation of optimized iPSC-based technology. This review introduces the main integrin-dependent mechanisms and signalling pathways involved in mechanotransduction. Special consideration is given to the integrin-iPSC linkage signalling chain in the cardiovascular field, focusing on biomaterial-based in vitro models to evaluate the relevance of this process in iPSC differentiation into cardiomyocytes.http://dx.doi.org/10.1155/2019/8203950 |
| spellingShingle | Rosaria Santoro Gianluca Lorenzo Perrucci Aoife Gowran Giulio Pompilio Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation Stem Cells International |
| title | Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation |
| title_full | Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation |
| title_fullStr | Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation |
| title_full_unstemmed | Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation |
| title_short | Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation |
| title_sort | unchain my heart integrins at the basis of ipsc cardiomyocyte differentiation |
| url | http://dx.doi.org/10.1155/2019/8203950 |
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