The origin and transmission of HIV-1 CRF80_0107 among two major first-tier cities in China
Abstract Background CRF01_AE and CRF07_BC are the two most prevalent HIV-1 genotypes in China, and the co-circulation of these two genotypes has led to the continuous generation of CRF_0107 viruses in recent years. However, little is known about the origin and spread of CRF_0107 viruses thus far. Th...
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BMC
2025-01-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-025-10461-0 |
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| author | Xiaorui Wang Bo Zhu Hanping Li Jingwan Han Xiaolin Wang Lei Jia Bohan Zhang Jingyun Li Linding Wang Yongjian Liu Hongling Wen Lin Li |
| author_facet | Xiaorui Wang Bo Zhu Hanping Li Jingwan Han Xiaolin Wang Lei Jia Bohan Zhang Jingyun Li Linding Wang Yongjian Liu Hongling Wen Lin Li |
| author_sort | Xiaorui Wang |
| collection | DOAJ |
| description | Abstract Background CRF01_AE and CRF07_BC are the two most prevalent HIV-1 genotypes in China, and the co-circulation of these two genotypes has led to the continuous generation of CRF_0107 viruses in recent years. However, little is known about the origin and spread of CRF_0107 viruses thus far. This study focused on HIV-1 CRF80_0107, which we previously identified among the MSM population in Beijing and Hebei Province, to explore the demographic distribution, transmission links, and temporal-spatial evolutionary features of the HIV-1 CRF80_0107 strain in China. Methods With the partial pol region fragment of the HIV-1 CRF80_0107 subtype standard sequence as a reference, BLAST was used to search for highly similar sequences in the Los Alamos HIV Sequence Database, followed by preliminary subtype identification via COMET. Further phylogenetic and recombination breakpoint analyses were conducted to verify the subtypes and recombination patterns. We also performed a distance-based molecular network analysis to identify potential relationships among different HIV-positive individuals. In addition, spatiotemporal evolutionary dynamics analysis of the candidate CRF80_0107 sequences was performed via a Bayesian approach. Results A total of 36 partial pol gene sequences of HIV-1 CRF80_0107 were identified from 2009 to 2018 from 5 provinces in China. Phylogenetic and spatial-temporal dynamics analyses indicated that CRF80_0107 likely originated in Beijing around 2009 and spread to Guangdong Province around 2012. Population dynamics analysis revealed that CRF80_0107 experienced a significant increase in population size from 2009 to 2011 and then stabilized. The study also found that the number of cases in Guangdong Province was second only to that in Beijing and formed 2 relatively independent transmission clusters in the MSM population in Shenzhen, Guangdong Province. Conclusions The HIV-1 CRF80_0107 strain has spread to cities beyond its origin, particularly the MSM population in Shenzhen city, Guangdong Province, which is an area with a high incidence of HIV. This highlights the importance of continuous monitoring for the emergence and dynamic changes of novel HIV-1 recombinant viruses and the necessity of implementing effective preventive measures targeting specific populations in particular regions. |
| format | Article |
| id | doaj-art-4ed2cbfce17e48959fb003c33b8d96c2 |
| institution | Kabale University |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Infectious Diseases |
| spelling | doaj-art-4ed2cbfce17e48959fb003c33b8d96c22025-01-26T12:17:12ZengBMCBMC Infectious Diseases1471-23342025-01-0125111010.1186/s12879-025-10461-0The origin and transmission of HIV-1 CRF80_0107 among two major first-tier cities in ChinaXiaorui Wang0Bo Zhu1Hanping Li2Jingwan Han3Xiaolin Wang4Lei Jia5Bohan Zhang6Jingyun Li7Linding Wang8Yongjian Liu9Hongling Wen10Lin Li11Department of Health Inspection and Quarantine, School of Public Health, Cheeloo College of Medicine, Shandong Provincial Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Biosafety in Higher Education Institutions, Shandong Provincial Key Laboratory of Intelligent Monitoring, Early Warning, Prevention and Control for Infectious Diseases, Shandong UniversityDepartment of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong UniversityState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical SciencesState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical SciencesState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical SciencesState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical SciencesState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical SciencesState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical SciencesAnhui Medical UniversityState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical SciencesDepartment of Health Inspection and Quarantine, School of Public Health, Cheeloo College of Medicine, Shandong Provincial Key Laboratory for Prevention and Control of Emerging Infectious Diseases and Biosafety in Higher Education Institutions, Shandong Provincial Key Laboratory of Intelligent Monitoring, Early Warning, Prevention and Control for Infectious Diseases, Shandong UniversityState Key Laboratory of Pathogen and Biosecurity, Academy of Military Medical SciencesAbstract Background CRF01_AE and CRF07_BC are the two most prevalent HIV-1 genotypes in China, and the co-circulation of these two genotypes has led to the continuous generation of CRF_0107 viruses in recent years. However, little is known about the origin and spread of CRF_0107 viruses thus far. This study focused on HIV-1 CRF80_0107, which we previously identified among the MSM population in Beijing and Hebei Province, to explore the demographic distribution, transmission links, and temporal-spatial evolutionary features of the HIV-1 CRF80_0107 strain in China. Methods With the partial pol region fragment of the HIV-1 CRF80_0107 subtype standard sequence as a reference, BLAST was used to search for highly similar sequences in the Los Alamos HIV Sequence Database, followed by preliminary subtype identification via COMET. Further phylogenetic and recombination breakpoint analyses were conducted to verify the subtypes and recombination patterns. We also performed a distance-based molecular network analysis to identify potential relationships among different HIV-positive individuals. In addition, spatiotemporal evolutionary dynamics analysis of the candidate CRF80_0107 sequences was performed via a Bayesian approach. Results A total of 36 partial pol gene sequences of HIV-1 CRF80_0107 were identified from 2009 to 2018 from 5 provinces in China. Phylogenetic and spatial-temporal dynamics analyses indicated that CRF80_0107 likely originated in Beijing around 2009 and spread to Guangdong Province around 2012. Population dynamics analysis revealed that CRF80_0107 experienced a significant increase in population size from 2009 to 2011 and then stabilized. The study also found that the number of cases in Guangdong Province was second only to that in Beijing and formed 2 relatively independent transmission clusters in the MSM population in Shenzhen, Guangdong Province. Conclusions The HIV-1 CRF80_0107 strain has spread to cities beyond its origin, particularly the MSM population in Shenzhen city, Guangdong Province, which is an area with a high incidence of HIV. This highlights the importance of continuous monitoring for the emergence and dynamic changes of novel HIV-1 recombinant viruses and the necessity of implementing effective preventive measures targeting specific populations in particular regions.https://doi.org/10.1186/s12879-025-10461-0HIV-1CRF80_0107EpidemicNetworkSpatiotemporal dynamics |
| spellingShingle | Xiaorui Wang Bo Zhu Hanping Li Jingwan Han Xiaolin Wang Lei Jia Bohan Zhang Jingyun Li Linding Wang Yongjian Liu Hongling Wen Lin Li The origin and transmission of HIV-1 CRF80_0107 among two major first-tier cities in China BMC Infectious Diseases HIV-1 CRF80_0107 Epidemic Network Spatiotemporal dynamics |
| title | The origin and transmission of HIV-1 CRF80_0107 among two major first-tier cities in China |
| title_full | The origin and transmission of HIV-1 CRF80_0107 among two major first-tier cities in China |
| title_fullStr | The origin and transmission of HIV-1 CRF80_0107 among two major first-tier cities in China |
| title_full_unstemmed | The origin and transmission of HIV-1 CRF80_0107 among two major first-tier cities in China |
| title_short | The origin and transmission of HIV-1 CRF80_0107 among two major first-tier cities in China |
| title_sort | origin and transmission of hiv 1 crf80 0107 among two major first tier cities in china |
| topic | HIV-1 CRF80_0107 Epidemic Network Spatiotemporal dynamics |
| url | https://doi.org/10.1186/s12879-025-10461-0 |
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