Targeted Therapy in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is one of the commonest cancers worldwide, as well as a common cause of cancer-related death. HCC frequently occurs in the setting of a diseased cirrhotic liver and many patients present at an advanced stage of disease. Together with a poor functional status, this ofte...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.4061/2011/348297 |
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| _version_ | 1832566892080922624 |
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| author | Clarinda W. L. Chua Su Pin Choo |
| author_facet | Clarinda W. L. Chua Su Pin Choo |
| author_sort | Clarinda W. L. Chua |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is one of the commonest cancers worldwide, as well as a common cause of cancer-related death. HCC frequently occurs in the setting of a diseased cirrhotic liver and many patients present at an advanced stage of disease. Together with a poor functional status, this often precludes the use of systemic therapy, especially conventional cytotoxic drugs. Moreover, HCC is known to be a relatively chemo-refractory tumor. There have been many targeted drugs that have shown potential in the treatment of HCC. Many clinical trials have been carried out with many more in progress. They include trials evaluating a single targeted therapy alone, two or more targeted therapy in tandem or a combination of targeted therapy and conventional chemotherapy. In this article, we seek to review some of the more important trials examining the use of targeted therapy in HCC and to look into what the future holds in terms of targeted treatment of HCC. |
| format | Article |
| id | doaj-art-4ecbc3ccedb140e990e332f364a4f08e |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-4ecbc3ccedb140e990e332f364a4f08e2025-02-03T01:02:56ZengWileyInternational Journal of Hepatology2090-34482090-34562011-01-01201110.4061/2011/348297348297Targeted Therapy in Hepatocellular CarcinomaClarinda W. L. Chua0Su Pin Choo1Department of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, 169610, SingaporeDepartment of Medical Oncology, National Cancer Centre Singapore, 11 Hospital Drive, 169610, SingaporeHepatocellular carcinoma (HCC) is one of the commonest cancers worldwide, as well as a common cause of cancer-related death. HCC frequently occurs in the setting of a diseased cirrhotic liver and many patients present at an advanced stage of disease. Together with a poor functional status, this often precludes the use of systemic therapy, especially conventional cytotoxic drugs. Moreover, HCC is known to be a relatively chemo-refractory tumor. There have been many targeted drugs that have shown potential in the treatment of HCC. Many clinical trials have been carried out with many more in progress. They include trials evaluating a single targeted therapy alone, two or more targeted therapy in tandem or a combination of targeted therapy and conventional chemotherapy. In this article, we seek to review some of the more important trials examining the use of targeted therapy in HCC and to look into what the future holds in terms of targeted treatment of HCC.http://dx.doi.org/10.4061/2011/348297 |
| spellingShingle | Clarinda W. L. Chua Su Pin Choo Targeted Therapy in Hepatocellular Carcinoma International Journal of Hepatology |
| title | Targeted Therapy in Hepatocellular Carcinoma |
| title_full | Targeted Therapy in Hepatocellular Carcinoma |
| title_fullStr | Targeted Therapy in Hepatocellular Carcinoma |
| title_full_unstemmed | Targeted Therapy in Hepatocellular Carcinoma |
| title_short | Targeted Therapy in Hepatocellular Carcinoma |
| title_sort | targeted therapy in hepatocellular carcinoma |
| url | http://dx.doi.org/10.4061/2011/348297 |
| work_keys_str_mv | AT clarindawlchua targetedtherapyinhepatocellularcarcinoma AT supinchoo targetedtherapyinhepatocellularcarcinoma |