Evaluation of Intrapulmonary Shunt Alterations at Different Oxygen Concentrations and Oxygenation Parameters
Aim: The aim of the current study was to evaluate the relationship of intrapulmonary shunt with FiO2 alterations in patients treated with mechanical ventilation in intensive care unit for extrapulmonary disorders. Also, we aimed to assess the role of correlation between shunt ratio and PaO2/FiO2...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Galenos Publishing House
2015-06-01
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| Series: | Haseki Tıp Bülteni |
| Subjects: | |
| Online Access: | http://www.hasekidergisi.com/article_8934/Evaluation-Of-Intrapulmonary-Shunt-Alterations-At-Different-Oxygen-Concentrations-And-Oxygenation-Parameters |
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| Summary: | Aim: The aim of the current study was to evaluate the relationship
of intrapulmonary shunt with FiO2 alterations in patients
treated with mechanical ventilation in intensive care unit for
extrapulmonary disorders. Also, we aimed to assess the role of
correlation between shunt ratio and PaO2/FiO2, PaO2/PAO2, P(A-a)
O2 values in determining the treatment strategies.
Methods: Twenty patients between ages of 19 and 75 years,
requiring mechanical ventilation were enrolled into the study. We
excluded two patients due to congestive heart failure and two
patients due to acute respiratory distress syndrome (ARDS). Shunt
fraction, P(A-a)O2, PaO2/FiO2, PaO2/PAO2 values were calculated
at each FiO2 level for each patient.
Results: The lowest median shunt value was measured at FiO2:
0.3 There was a significant correlation between shunt values at
FiO2 0.5 and 0.7 (r=0.850). The highest mean value of P(A-a)O2
was measured at FiO2: 1 (382.91±106.46), and the lowest value of
P(A-a)O2 was measured at FiO2: 0.21 (38.64±16.97). PaO2/FiO2
and PaO2/PAO2 ratios measured at FiO2: 0.3 and 0.5 were found
to be statistically significant.
Conclusion: In this study, we have shown increased shunt
fraction at FiO2: 1 level. Different oxygenation indices and shunt
measurements give us important and useful knowledge about the
patients’ current condition. (The Medical Bulletin of Haseki 2015;
53:124-9) |
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| ISSN: | 1302-0072 2147-2688 |