Alzheimer's disease and sleep disturbances: a review
ABSTRACT The association between Alzheimer's disease (AD) and sleep disturbances has received increasing scientific attention in the last decades. However, little is known about the impact of sleep and its disturbances on the development of preclinical AD stages, such as mild cognitive impairme...
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| Format: | Article |
| Language: | English |
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Thieme Revinter Publicações
2019-12-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019001100815&tlng=en |
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| _version_ | 1849696648603631616 |
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| author | Conrado Regis Borges Dalva Poyares Ronaldo Piovezan Ricardo Nitrini Sonia Brucki |
| author_facet | Conrado Regis Borges Dalva Poyares Ronaldo Piovezan Ricardo Nitrini Sonia Brucki |
| author_sort | Conrado Regis Borges |
| collection | DOAJ |
| description | ABSTRACT The association between Alzheimer's disease (AD) and sleep disturbances has received increasing scientific attention in the last decades. However, little is known about the impact of sleep and its disturbances on the development of preclinical AD stages, such as mild cognitive impairment. This review describes the evolution of knowledge about the potential bidirectional relationships between AD and sleep disturbances exploring recent large prospective studies and meta-analyses and studies of the possible mechanisms through which sleep and the neurodegenerative process could be associated. The review also makes a comprehensive exploration of the sleep characteristics of older people, ranging from cognitively normal individuals, through patients with mild cognitive impairment, up to the those with dementia with AD. |
| format | Article |
| id | doaj-art-4ec39c6875ec4612acb51e4fdc8086bb |
| institution | DOAJ |
| issn | 1678-4227 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-4ec39c6875ec4612acb51e4fdc8086bb2025-08-20T03:19:24ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272019-12-01771181582410.1590/0004-282x20190149Alzheimer's disease and sleep disturbances: a reviewConrado Regis Borgeshttps://orcid.org/0000-0003-3220-7746Dalva Poyareshttps://orcid.org/0000-0003-0664-0968Ronaldo Piovezanhttps://orcid.org/0000-0003-2537-8766Ricardo Nitrinihttps://orcid.org/0000-0002-5721-1525Sonia Bruckihttps://orcid.org/0000-0002-8303-6732ABSTRACT The association between Alzheimer's disease (AD) and sleep disturbances has received increasing scientific attention in the last decades. However, little is known about the impact of sleep and its disturbances on the development of preclinical AD stages, such as mild cognitive impairment. This review describes the evolution of knowledge about the potential bidirectional relationships between AD and sleep disturbances exploring recent large prospective studies and meta-analyses and studies of the possible mechanisms through which sleep and the neurodegenerative process could be associated. The review also makes a comprehensive exploration of the sleep characteristics of older people, ranging from cognitively normal individuals, through patients with mild cognitive impairment, up to the those with dementia with AD.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019001100815&tlng=enAlzheimer diseasesleep initiation and maintenance disorderscognitive dysfunction |
| spellingShingle | Conrado Regis Borges Dalva Poyares Ronaldo Piovezan Ricardo Nitrini Sonia Brucki Alzheimer's disease and sleep disturbances: a review Arquivos de Neuro-Psiquiatria Alzheimer disease sleep initiation and maintenance disorders cognitive dysfunction |
| title | Alzheimer's disease and sleep disturbances: a review |
| title_full | Alzheimer's disease and sleep disturbances: a review |
| title_fullStr | Alzheimer's disease and sleep disturbances: a review |
| title_full_unstemmed | Alzheimer's disease and sleep disturbances: a review |
| title_short | Alzheimer's disease and sleep disturbances: a review |
| title_sort | alzheimer s disease and sleep disturbances a review |
| topic | Alzheimer disease sleep initiation and maintenance disorders cognitive dysfunction |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2019001100815&tlng=en |
| work_keys_str_mv | AT conradoregisborges alzheimersdiseaseandsleepdisturbancesareview AT dalvapoyares alzheimersdiseaseandsleepdisturbancesareview AT ronaldopiovezan alzheimersdiseaseandsleepdisturbancesareview AT ricardonitrini alzheimersdiseaseandsleepdisturbancesareview AT soniabrucki alzheimersdiseaseandsleepdisturbancesareview |