Atrial Arrhythmias in Obstructive Sleep Apnea: Underlying Mechanisms and Implications in the Clinical Setting
Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive interruption of ventilation during sleep caused by recurrent upper airway collapse, which leads to intermittent hypoxia. The disorder is commonly undiagnosed despite its relationship with substantial cardiovascular morbid...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Pulmonary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2013/426758 |
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| author | David Filgueiras-Rama Miguel A. Arias Ángel Iniesta Eduardo Armada José L. Merino Rafael Peinado J. L. López-Sendón |
| author_facet | David Filgueiras-Rama Miguel A. Arias Ángel Iniesta Eduardo Armada José L. Merino Rafael Peinado J. L. López-Sendón |
| author_sort | David Filgueiras-Rama |
| collection | DOAJ |
| description | Obstructive sleep apnea (OSA) is a common disorder characterized by repetitive interruption of ventilation during sleep caused by recurrent upper airway collapse, which leads to intermittent hypoxia. The disorder is commonly undiagnosed despite its relationship with substantial cardiovascular morbidity and mortality. Moreover, the effects of the disorder appear to be particularly dangerous in young subjects. In the last decade, substantial clinical evidence has identified OSA as independent risk factor for both bradyarrhythmias and tachyarrhythmias. To date the mechanisms leading to such arrhythmias have not been completely understood. However, recent data from animal models and new molecular analyses have increased our knowledge of the field, which might lead to future improvement in current therapeutic strategies mainly based on continuous positive airway pressure. This paper aims at providing readers a brief and specific revision of current knowledge about the mechanisms underlying atrial arrhythmias in OSA and their clinical and therapeutic implications. |
| format | Article |
| id | doaj-art-4ebc5e2d56ce42eca5bf5db6866cc42d |
| institution | Kabale University |
| issn | 2090-1836 2090-1844 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Medicine |
| spelling | doaj-art-4ebc5e2d56ce42eca5bf5db6866cc42d2025-02-03T06:12:16ZengWileyPulmonary Medicine2090-18362090-18442013-01-01201310.1155/2013/426758426758Atrial Arrhythmias in Obstructive Sleep Apnea: Underlying Mechanisms and Implications in the Clinical SettingDavid Filgueiras-Rama0Miguel A. Arias1Ángel Iniesta2Eduardo Armada3José L. Merino4Rafael Peinado5J. L. López-Sendón6Cardiac Electrophysiology Unit, Department of Cardiology, Hospital Universitario La Paz, Paseo de la Castellana 261, 1st floor, 28046 Madrid, SpainCardiac Arrhythmia and Electrophysiology Unit, Department of Cardiology, Hospital Virgen de la Salud, Toledo, SpainCardiac Electrophysiology Unit, Department of Cardiology, Hospital Universitario La Paz, Paseo de la Castellana 261, 1st floor, 28046 Madrid, SpainAcute Cardiac Care Unit, Department of Cardiology, Hospital Universitario La Paz, Madrid, SpainRobotic Cardiac Electrophysiology and Arrhythmia Unit, Hospital Universitario La Paz, Madrid, SpainCardiac Electrophysiology Unit, Department of Cardiology, Hospital Universitario La Paz, Paseo de la Castellana 261, 1st floor, 28046 Madrid, SpainDepartment of Cardiology, Hospital Universitario La Paz, Madrid, SpainObstructive sleep apnea (OSA) is a common disorder characterized by repetitive interruption of ventilation during sleep caused by recurrent upper airway collapse, which leads to intermittent hypoxia. The disorder is commonly undiagnosed despite its relationship with substantial cardiovascular morbidity and mortality. Moreover, the effects of the disorder appear to be particularly dangerous in young subjects. In the last decade, substantial clinical evidence has identified OSA as independent risk factor for both bradyarrhythmias and tachyarrhythmias. To date the mechanisms leading to such arrhythmias have not been completely understood. However, recent data from animal models and new molecular analyses have increased our knowledge of the field, which might lead to future improvement in current therapeutic strategies mainly based on continuous positive airway pressure. This paper aims at providing readers a brief and specific revision of current knowledge about the mechanisms underlying atrial arrhythmias in OSA and their clinical and therapeutic implications.http://dx.doi.org/10.1155/2013/426758 |
| spellingShingle | David Filgueiras-Rama Miguel A. Arias Ángel Iniesta Eduardo Armada José L. Merino Rafael Peinado J. L. López-Sendón Atrial Arrhythmias in Obstructive Sleep Apnea: Underlying Mechanisms and Implications in the Clinical Setting Pulmonary Medicine |
| title | Atrial Arrhythmias in Obstructive Sleep Apnea: Underlying Mechanisms and Implications in the Clinical Setting |
| title_full | Atrial Arrhythmias in Obstructive Sleep Apnea: Underlying Mechanisms and Implications in the Clinical Setting |
| title_fullStr | Atrial Arrhythmias in Obstructive Sleep Apnea: Underlying Mechanisms and Implications in the Clinical Setting |
| title_full_unstemmed | Atrial Arrhythmias in Obstructive Sleep Apnea: Underlying Mechanisms and Implications in the Clinical Setting |
| title_short | Atrial Arrhythmias in Obstructive Sleep Apnea: Underlying Mechanisms and Implications in the Clinical Setting |
| title_sort | atrial arrhythmias in obstructive sleep apnea underlying mechanisms and implications in the clinical setting |
| url | http://dx.doi.org/10.1155/2013/426758 |
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