Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy
Diabetic nephropathy (DN) is a frequent and severe complication of diabetes mellitus (DM). Its diagnosis in incipient stages may allow prompt interventions and an improved prognosis. Towards this aim, biomarkers for detecting early DN can be used. Microalbuminuria has been proven a remarkably useful...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2016/4626125 |
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| author | Cristina Gluhovschi Gheorghe Gluhovschi Ligia Petrica Romulus Timar Silvia Velciov Ioana Ionita Adriana Kaycsa Bogdan Timar |
| author_facet | Cristina Gluhovschi Gheorghe Gluhovschi Ligia Petrica Romulus Timar Silvia Velciov Ioana Ionita Adriana Kaycsa Bogdan Timar |
| author_sort | Cristina Gluhovschi |
| collection | DOAJ |
| description | Diabetic nephropathy (DN) is a frequent and severe complication of diabetes mellitus (DM). Its diagnosis in incipient stages may allow prompt interventions and an improved prognosis. Towards this aim, biomarkers for detecting early DN can be used. Microalbuminuria has been proven a remarkably useful biomarker, being used for diagnosis of DN, for assessing its associated condition—mainly cardiovascular ones—and for monitoring its progression. New researches are pointing that some of these biomarkers (i.e., glomerular, tubular, inflammation markers, and biomarkers of oxidative stress) precede albuminuria in some patients. However, their usefulness is widely debated in the literature and has not yet led to the validation of a new “gold standard” biomarker for the early diagnosis of DN. Currently, microalbuminuria is an important biomarker for both glomerular and tubular injury. Other glomerular biomarkers (transferrin and ceruloplasmin) are under evaluation. Tubular biomarkers in DN seem to be of a paramount importance in the early diagnosis of DN since tubular lesions occur early. Additionally, biomarkers of inflammation, oxidative stress, podocyte biomarkers, and vascular biomarkers have been employed for assessing early DN. The purpose of this review is to provide an overview of the current biomarkers used for the diagnosis of early DN. |
| format | Article |
| id | doaj-art-4eac6d8783e24131aa8fa05a3c6c6630 |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-4eac6d8783e24131aa8fa05a3c6c66302025-02-03T06:07:03ZengWileyJournal of Diabetes Research2314-67452314-67532016-01-01201610.1155/2016/46261254626125Urinary Biomarkers in the Assessment of Early Diabetic NephropathyCristina Gluhovschi0Gheorghe Gluhovschi1Ligia Petrica2Romulus Timar3Silvia Velciov4Ioana Ionita5Adriana Kaycsa6Bogdan Timar7Division of Nephrology, University of Medicine and Pharmacy “V. Babes”, 300041 Timisoara, RomaniaRomanian Academy of Medical Sciences, 300041 Timisoara, RomaniaDivision of Nephrology, University of Medicine and Pharmacy “V. Babes”, 300041 Timisoara, RomaniaDepartment of Diabetes and Metabolic Diseases, University of Medicine and Pharmacy “V. Babes”, 300041 Timisoara, RomaniaDivision of Nephrology, University of Medicine and Pharmacy “V. Babes”, 300041 Timisoara, RomaniaDivision of Hematology, University of Medicine and Pharmacy “V. Babes”, 300041 Timisoara, RomaniaDepartment of Biochemistry, University of Medicine and Pharmacy “V. Babes”, 300041 Timisoara, RomaniaDepartment of Diabetes and Metabolic Diseases, University of Medicine and Pharmacy “V. Babes”, 300041 Timisoara, RomaniaDiabetic nephropathy (DN) is a frequent and severe complication of diabetes mellitus (DM). Its diagnosis in incipient stages may allow prompt interventions and an improved prognosis. Towards this aim, biomarkers for detecting early DN can be used. Microalbuminuria has been proven a remarkably useful biomarker, being used for diagnosis of DN, for assessing its associated condition—mainly cardiovascular ones—and for monitoring its progression. New researches are pointing that some of these biomarkers (i.e., glomerular, tubular, inflammation markers, and biomarkers of oxidative stress) precede albuminuria in some patients. However, their usefulness is widely debated in the literature and has not yet led to the validation of a new “gold standard” biomarker for the early diagnosis of DN. Currently, microalbuminuria is an important biomarker for both glomerular and tubular injury. Other glomerular biomarkers (transferrin and ceruloplasmin) are under evaluation. Tubular biomarkers in DN seem to be of a paramount importance in the early diagnosis of DN since tubular lesions occur early. Additionally, biomarkers of inflammation, oxidative stress, podocyte biomarkers, and vascular biomarkers have been employed for assessing early DN. The purpose of this review is to provide an overview of the current biomarkers used for the diagnosis of early DN.http://dx.doi.org/10.1155/2016/4626125 |
| spellingShingle | Cristina Gluhovschi Gheorghe Gluhovschi Ligia Petrica Romulus Timar Silvia Velciov Ioana Ionita Adriana Kaycsa Bogdan Timar Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy Journal of Diabetes Research |
| title | Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy |
| title_full | Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy |
| title_fullStr | Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy |
| title_full_unstemmed | Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy |
| title_short | Urinary Biomarkers in the Assessment of Early Diabetic Nephropathy |
| title_sort | urinary biomarkers in the assessment of early diabetic nephropathy |
| url | http://dx.doi.org/10.1155/2016/4626125 |
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