Protective effect of Helicteres isora, an efficient candidate on hepatorenal toxicity and management of diabetes in animal models
Diabetes is a metabolic disorder of the carbohydrate pathway, resulting in high blood glucose levels, an increase in thirst as well as urination, problems in vision, weight loss, and high ketone body excretion in urine. Diabetes also affects the endocrine, neurological, and circulatory systems, rais...
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-06-01
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| Series: | Open Chemistry |
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| Online Access: | https://doi.org/10.1515/chem-2025-0133 |
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| author | Bilal Hayat Khan Mubarak Ali Shah Syed Wadood Ali Ghias Mehreen Khan Adnan Zahoor Muhammad Ullah Riaz Iqbal Zafar Shah Abdul Bari |
| author_facet | Bilal Hayat Khan Mubarak Ali Shah Syed Wadood Ali Ghias Mehreen Khan Adnan Zahoor Muhammad Ullah Riaz Iqbal Zafar Shah Abdul Bari |
| author_sort | Bilal Hayat |
| collection | DOAJ |
| description | Diabetes is a metabolic disorder of the carbohydrate pathway, resulting in high blood glucose levels, an increase in thirst as well as urination, problems in vision, weight loss, and high ketone body excretion in urine. Diabetes also affects the endocrine, neurological, and circulatory systems, raising blood pressure and lowering high-density lipoprotein levels with subsequent increases in the low-density lipoprotein level. Helicteres isora (H. isora) is a promising medicinal plant having both anti-oxidant and anti-diabetic potentials. Herein, we investigate the protective effect of H. isora extracts (crude and fractions) on paracetamol-induced hepatorenal toxicities in animal models. The extracts were initially screened for in vivo antidiabetic potential using the alloxan-induced diabetic model. The experimental rats treated with 150 mg/kg b.w. (body weight) dose of Hi-Chl extract decreased the creatinine level to 0.48 ± 0.07 mg/dL, blood urea to 19.64 ± 1.22 mg/dL, and uric acid to 2.23 ± 0.21 mg/dL, indicating the hepatorenal protective functions of the extract. Serum glutamic pyruvic transaminase and alkaline phosphatase were also normalized by the extract to 73.10 ± 4.40 mg/dL and 174.6 ± 2.81 mg/dL, respectively. The Hi-Chl extract exhibited promising anti-diabetic potential with blood glucose normalizing effect from 494.8 ± 2.52 to 159.6 ± 2.67 to 125.6 ± 3.72 mg/dL at doses of 75 and 150 mg/kg, respectively. |
| format | Article |
| id | doaj-art-4e98e76bfbfc413c85b6cd438d42bbc4 |
| institution | Kabale University |
| issn | 2391-5420 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Open Chemistry |
| spelling | doaj-art-4e98e76bfbfc413c85b6cd438d42bbc42025-08-20T03:47:21ZengDe GruyterOpen Chemistry2391-54202025-06-012316910.1515/chem-2025-0133Protective effect of Helicteres isora, an efficient candidate on hepatorenal toxicity and management of diabetes in animal modelsBilal Hayat0Khan Mubarak Ali1Shah Syed Wadood Ali2Ghias Mehreen3Khan Adnan4Zahoor Muhammad5Ullah Riaz6Iqbal Zafar7Shah Abdul Bari8Department of Biotechnology, Abdul Wali Khan University Mardan (AWKUM), Mardan, 23390, PakistanDepartment of Biotechnology, Abdul Wali Khan University Mardan (AWKUM), Mardan, 23390, PakistanDepartment of Pharmacy, University of Malakand, Chakdara, Chakdara, 18800, Khyber Pakhtunkhwa, PakistanDepartment of Pharmacy, University of Malakand, Chakdara, Chakdara, 18800, Khyber Pakhtunkhwa, PakistanDepartment of Chemistry, University of Malakand, Chakdara, 18800, PakistanDepartment of Biochemistry, University of Malakand, Chakdara, Dir Lower, KPK, 18800, PakistanDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi ArabiaDepartment of Surgery, College of Medicine, King Saud University, P.O.Box 7805, Riyadh, 11472, Saudi ArabiaNatural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, 08826, Republic of KoreaDiabetes is a metabolic disorder of the carbohydrate pathway, resulting in high blood glucose levels, an increase in thirst as well as urination, problems in vision, weight loss, and high ketone body excretion in urine. Diabetes also affects the endocrine, neurological, and circulatory systems, raising blood pressure and lowering high-density lipoprotein levels with subsequent increases in the low-density lipoprotein level. Helicteres isora (H. isora) is a promising medicinal plant having both anti-oxidant and anti-diabetic potentials. Herein, we investigate the protective effect of H. isora extracts (crude and fractions) on paracetamol-induced hepatorenal toxicities in animal models. The extracts were initially screened for in vivo antidiabetic potential using the alloxan-induced diabetic model. The experimental rats treated with 150 mg/kg b.w. (body weight) dose of Hi-Chl extract decreased the creatinine level to 0.48 ± 0.07 mg/dL, blood urea to 19.64 ± 1.22 mg/dL, and uric acid to 2.23 ± 0.21 mg/dL, indicating the hepatorenal protective functions of the extract. Serum glutamic pyruvic transaminase and alkaline phosphatase were also normalized by the extract to 73.10 ± 4.40 mg/dL and 174.6 ± 2.81 mg/dL, respectively. The Hi-Chl extract exhibited promising anti-diabetic potential with blood glucose normalizing effect from 494.8 ± 2.52 to 159.6 ± 2.67 to 125.6 ± 3.72 mg/dL at doses of 75 and 150 mg/kg, respectively.https://doi.org/10.1515/chem-2025-0133helicteres isorahepatotoxicitynephrotoxicitydiabetesserum profilingbiochemical analysis |
| spellingShingle | Bilal Hayat Khan Mubarak Ali Shah Syed Wadood Ali Ghias Mehreen Khan Adnan Zahoor Muhammad Ullah Riaz Iqbal Zafar Shah Abdul Bari Protective effect of Helicteres isora, an efficient candidate on hepatorenal toxicity and management of diabetes in animal models Open Chemistry helicteres isora hepatotoxicity nephrotoxicity diabetes serum profiling biochemical analysis |
| title | Protective effect of Helicteres isora, an efficient candidate on hepatorenal toxicity and management of diabetes in animal models |
| title_full | Protective effect of Helicteres isora, an efficient candidate on hepatorenal toxicity and management of diabetes in animal models |
| title_fullStr | Protective effect of Helicteres isora, an efficient candidate on hepatorenal toxicity and management of diabetes in animal models |
| title_full_unstemmed | Protective effect of Helicteres isora, an efficient candidate on hepatorenal toxicity and management of diabetes in animal models |
| title_short | Protective effect of Helicteres isora, an efficient candidate on hepatorenal toxicity and management of diabetes in animal models |
| title_sort | protective effect of helicteres isora an efficient candidate on hepatorenal toxicity and management of diabetes in animal models |
| topic | helicteres isora hepatotoxicity nephrotoxicity diabetes serum profiling biochemical analysis |
| url | https://doi.org/10.1515/chem-2025-0133 |
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