Platelets tune fear memory in mice
Summary: Several lines of evidence have shown that platelet-derived factors are key molecules in brain-body communication in pathological conditions. Here, we identify platelets as key actors in the modulation of fear behaviors in mice through the control of inhibitory neurotransmission and plastici...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-02-01
|
| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124725000324 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832542440620294144 |
|---|---|
| author | Stefano Garofalo Alessandro Mormino Letizia Mazzarella Germana Cocozza Arianna Rinaldi Erika Di Pietro Maria Amalia Di Castro Eleonora De Felice Laura Maggi Giuseppina Chece Diego Andolina Rossella Ventura Donald Ielpo Roberto Piacentini Myriam Catalano Lucia Stefanini Cristina Limatola |
| author_facet | Stefano Garofalo Alessandro Mormino Letizia Mazzarella Germana Cocozza Arianna Rinaldi Erika Di Pietro Maria Amalia Di Castro Eleonora De Felice Laura Maggi Giuseppina Chece Diego Andolina Rossella Ventura Donald Ielpo Roberto Piacentini Myriam Catalano Lucia Stefanini Cristina Limatola |
| author_sort | Stefano Garofalo |
| collection | DOAJ |
| description | Summary: Several lines of evidence have shown that platelet-derived factors are key molecules in brain-body communication in pathological conditions. Here, we identify platelets as key actors in the modulation of fear behaviors in mice through the control of inhibitory neurotransmission and plasticity in the hippocampus. Interfering with platelet number or activation reduces hippocampal serotonin (5-HT) and modulates fear learning and memory in mice, and this effect is reversed by serotonin replacement by serotonin precursor (5-HTP)/benserazide. In addition, we unravel that natural killer (NK) cells participate in this mechanism, regulating interleukin-13 (IL-13) levels in the gut, with effects on serotonin production by enterochromaffin cells and uptake by platelets. Both NK cells and platelet depletion reduce the activation of hippocampal inhibitory neurons and increase the long-term potentiation of synaptic transmission. Understanding the role of platelets in the modulation of neuro-immune interactions offers additional tools for the definition of the molecular and cellular elements involved in the growing field of brain-body communication. |
| format | Article |
| id | doaj-art-4e97ed68fa144cfb9aa6ecd9709e90f8 |
| institution | Kabale University |
| issn | 2211-1247 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj-art-4e97ed68fa144cfb9aa6ecd9709e90f82025-02-04T04:10:23ZengElsevierCell Reports2211-12472025-02-01442115261Platelets tune fear memory in miceStefano Garofalo0Alessandro Mormino1Letizia Mazzarella2Germana Cocozza3Arianna Rinaldi4Erika Di Pietro5Maria Amalia Di Castro6Eleonora De Felice7Laura Maggi8Giuseppina Chece9Diego Andolina10Rossella Ventura11Donald Ielpo12Roberto Piacentini13Myriam Catalano14Lucia Stefanini15Cristina Limatola16Department of Physiology and Pharmacology, Sapienza University of Rome, Rome, Italy; Corresponding authorDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, ItalyDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, ItalyDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, ItalyDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, ItalyDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, ItalyDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, ItalyDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, ItalyDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, ItalyDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, ItalyDepartment of Psychology and Center for Research in Neurobiology ‘D. Bovet’, Sapienza University of Rome, Rome, ItalyDepartment of Psychology and Center for Research in Neurobiology ‘D. Bovet’, Sapienza University of Rome, Rome, ItalyDepartment of Psychology and Center for Research in Neurobiology ‘D. Bovet’, Sapienza University of Rome, Rome, ItalyDepartment of Neuroscience, Università Cattolica del Sacro Cuore, Rome, Italy; IRCCS Fondazione Policlinico Universitario A. Gemelli, Largo A. Gemelli 1, Roma, ItalyDepartment of Physiology and Pharmacology, Sapienza University of Rome, Rome, ItalyDepartment of Translational and Precision Medicine, Sapienza University of Rome, Rome, ItalyLaboratory affiliated with Istituto Pasteur, Department of Physiology and Pharmacology, Sapienza University, Rome, Italy; IRCCS Neuromed, Pozzilli, Italy; Corresponding authorSummary: Several lines of evidence have shown that platelet-derived factors are key molecules in brain-body communication in pathological conditions. Here, we identify platelets as key actors in the modulation of fear behaviors in mice through the control of inhibitory neurotransmission and plasticity in the hippocampus. Interfering with platelet number or activation reduces hippocampal serotonin (5-HT) and modulates fear learning and memory in mice, and this effect is reversed by serotonin replacement by serotonin precursor (5-HTP)/benserazide. In addition, we unravel that natural killer (NK) cells participate in this mechanism, regulating interleukin-13 (IL-13) levels in the gut, with effects on serotonin production by enterochromaffin cells and uptake by platelets. Both NK cells and platelet depletion reduce the activation of hippocampal inhibitory neurons and increase the long-term potentiation of synaptic transmission. Understanding the role of platelets in the modulation of neuro-immune interactions offers additional tools for the definition of the molecular and cellular elements involved in the growing field of brain-body communication.http://www.sciencedirect.com/science/article/pii/S2211124725000324CP: NeuroscienceCP: Immunology |
| spellingShingle | Stefano Garofalo Alessandro Mormino Letizia Mazzarella Germana Cocozza Arianna Rinaldi Erika Di Pietro Maria Amalia Di Castro Eleonora De Felice Laura Maggi Giuseppina Chece Diego Andolina Rossella Ventura Donald Ielpo Roberto Piacentini Myriam Catalano Lucia Stefanini Cristina Limatola Platelets tune fear memory in mice Cell Reports CP: Neuroscience CP: Immunology |
| title | Platelets tune fear memory in mice |
| title_full | Platelets tune fear memory in mice |
| title_fullStr | Platelets tune fear memory in mice |
| title_full_unstemmed | Platelets tune fear memory in mice |
| title_short | Platelets tune fear memory in mice |
| title_sort | platelets tune fear memory in mice |
| topic | CP: Neuroscience CP: Immunology |
| url | http://www.sciencedirect.com/science/article/pii/S2211124725000324 |
| work_keys_str_mv | AT stefanogarofalo plateletstunefearmemoryinmice AT alessandromormino plateletstunefearmemoryinmice AT letiziamazzarella plateletstunefearmemoryinmice AT germanacocozza plateletstunefearmemoryinmice AT ariannarinaldi plateletstunefearmemoryinmice AT erikadipietro plateletstunefearmemoryinmice AT mariaamaliadicastro plateletstunefearmemoryinmice AT eleonoradefelice plateletstunefearmemoryinmice AT lauramaggi plateletstunefearmemoryinmice AT giuseppinachece plateletstunefearmemoryinmice AT diegoandolina plateletstunefearmemoryinmice AT rossellaventura plateletstunefearmemoryinmice AT donaldielpo plateletstunefearmemoryinmice AT robertopiacentini plateletstunefearmemoryinmice AT myriamcatalano plateletstunefearmemoryinmice AT luciastefanini plateletstunefearmemoryinmice AT cristinalimatola plateletstunefearmemoryinmice |