The effects of heparinized normal saline flushing and prophylactic enoxaparin on central venous catheter thrombosis in PICU hospitalized pediatric
Background: Central venous catheter (CVC) thrombosis is one of the most common complications of CVC that occurs in children and adults. Prevention of this blockage improves the treatment process and reduces treatment costs. Due to the lack of studies on preventive methods of CVC thrombosis, this st...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tehran University of Medical Sciences
2024-07-01
|
| Series: | Archives of Anesthesia and Critical Care |
| Subjects: | |
| Online Access: | https://aacc.tums.ac.ir/index.php/aacc/article/view/992 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850137144228577280 |
|---|---|
| author | Maryam Mohebbi Effat Hosseinali Beigi Rezvaneh Mohebbi Maryam Ghodsi |
| author_facet | Maryam Mohebbi Effat Hosseinali Beigi Rezvaneh Mohebbi Maryam Ghodsi |
| author_sort | Maryam Mohebbi |
| collection | DOAJ |
| description |
Background: Central venous catheter (CVC) thrombosis is one of the most common complications of CVC that occurs in children and adults. Prevention of this blockage improves the treatment process and reduces treatment costs. Due to the lack of studies on preventive methods of CVC thrombosis, this study aimed to examine the effect of NS flushing heparinized and prophylactic dose of enoxaparin in prevention of CVC induced thrombosis in hospitalized patients in pediatric intensive care unit (PICU).
Methods: Eighty pediatrics with Central venous catheter admitted to the PICU enrolled in this trial and were divided into two groups as receiving heparinized normal saline was flushed every 8 hours under sterile conditions and receiving enoxaparin trough injection subcutaneously every 12 hours. The incidence of CVC-related thrombosis, diagnosed using color Doppler ultrasound of the vein containing the catheter was measured. Patients were monitored daily in terms of clinical symptoms related to thrombosis.
Results: There was no statistically significant difference in gender, age, anthropometric findings and vital sign as well as risk factors between two groups of the trial (P>0.05). Additionally, the finding showed a statistically significant relationship between major surgery (P=0.01) and heart disease (P=0.03) with symptomatic and asymptomatic thrombosis between the enoxaparin and heparinized normal saline groups. The rate of sepsis and bleeding were lower in enoxaparin group but it was not significant between study groups.
Conclusion: These findings indicate that enoxaparin may be considered as a clinical approach in thrombosis management and more clinical trials are needed.
|
| format | Article |
| id | doaj-art-4e89378c8bbe42e5b5f91f65ee9b2887 |
| institution | OA Journals |
| issn | 2423-5849 |
| language | English |
| publishDate | 2024-07-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Archives of Anesthesia and Critical Care |
| spelling | doaj-art-4e89378c8bbe42e5b5f91f65ee9b28872025-08-20T02:30:56ZengTehran University of Medical SciencesArchives of Anesthesia and Critical Care2423-58492024-07-0110Supp. 2The effects of heparinized normal saline flushing and prophylactic enoxaparin on central venous catheter thrombosis in PICU hospitalized pediatricMaryam Mohebbi0Effat Hosseinali Beigi1Rezvaneh Mohebbi2Maryam Ghodsi3Department of Pediatrics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department Pediatrics, Bahrami Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.Department of Clinical Pharmacy, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran.Department of Pediatric Intensive Care Unit, Bahrami Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Background: Central venous catheter (CVC) thrombosis is one of the most common complications of CVC that occurs in children and adults. Prevention of this blockage improves the treatment process and reduces treatment costs. Due to the lack of studies on preventive methods of CVC thrombosis, this study aimed to examine the effect of NS flushing heparinized and prophylactic dose of enoxaparin in prevention of CVC induced thrombosis in hospitalized patients in pediatric intensive care unit (PICU). Methods: Eighty pediatrics with Central venous catheter admitted to the PICU enrolled in this trial and were divided into two groups as receiving heparinized normal saline was flushed every 8 hours under sterile conditions and receiving enoxaparin trough injection subcutaneously every 12 hours. The incidence of CVC-related thrombosis, diagnosed using color Doppler ultrasound of the vein containing the catheter was measured. Patients were monitored daily in terms of clinical symptoms related to thrombosis. Results: There was no statistically significant difference in gender, age, anthropometric findings and vital sign as well as risk factors between two groups of the trial (P>0.05). Additionally, the finding showed a statistically significant relationship between major surgery (P=0.01) and heart disease (P=0.03) with symptomatic and asymptomatic thrombosis between the enoxaparin and heparinized normal saline groups. The rate of sepsis and bleeding were lower in enoxaparin group but it was not significant between study groups. Conclusion: These findings indicate that enoxaparin may be considered as a clinical approach in thrombosis management and more clinical trials are needed. https://aacc.tums.ac.ir/index.php/aacc/article/view/992HeparinEnoxaparinThrombosisPICUCentral venous catheterPediatric |
| spellingShingle | Maryam Mohebbi Effat Hosseinali Beigi Rezvaneh Mohebbi Maryam Ghodsi The effects of heparinized normal saline flushing and prophylactic enoxaparin on central venous catheter thrombosis in PICU hospitalized pediatric Archives of Anesthesia and Critical Care Heparin Enoxaparin Thrombosis PICU Central venous catheter Pediatric |
| title | The effects of heparinized normal saline flushing and prophylactic enoxaparin on central venous catheter thrombosis in PICU hospitalized pediatric |
| title_full | The effects of heparinized normal saline flushing and prophylactic enoxaparin on central venous catheter thrombosis in PICU hospitalized pediatric |
| title_fullStr | The effects of heparinized normal saline flushing and prophylactic enoxaparin on central venous catheter thrombosis in PICU hospitalized pediatric |
| title_full_unstemmed | The effects of heparinized normal saline flushing and prophylactic enoxaparin on central venous catheter thrombosis in PICU hospitalized pediatric |
| title_short | The effects of heparinized normal saline flushing and prophylactic enoxaparin on central venous catheter thrombosis in PICU hospitalized pediatric |
| title_sort | effects of heparinized normal saline flushing and prophylactic enoxaparin on central venous catheter thrombosis in picu hospitalized pediatric |
| topic | Heparin Enoxaparin Thrombosis PICU Central venous catheter Pediatric |
| url | https://aacc.tums.ac.ir/index.php/aacc/article/view/992 |
| work_keys_str_mv | AT maryammohebbi theeffectsofheparinizednormalsalineflushingandprophylacticenoxaparinoncentralvenouscatheterthrombosisinpicuhospitalizedpediatric AT effathosseinalibeigi theeffectsofheparinizednormalsalineflushingandprophylacticenoxaparinoncentralvenouscatheterthrombosisinpicuhospitalizedpediatric AT rezvanehmohebbi theeffectsofheparinizednormalsalineflushingandprophylacticenoxaparinoncentralvenouscatheterthrombosisinpicuhospitalizedpediatric AT maryamghodsi theeffectsofheparinizednormalsalineflushingandprophylacticenoxaparinoncentralvenouscatheterthrombosisinpicuhospitalizedpediatric AT maryammohebbi effectsofheparinizednormalsalineflushingandprophylacticenoxaparinoncentralvenouscatheterthrombosisinpicuhospitalizedpediatric AT effathosseinalibeigi effectsofheparinizednormalsalineflushingandprophylacticenoxaparinoncentralvenouscatheterthrombosisinpicuhospitalizedpediatric AT rezvanehmohebbi effectsofheparinizednormalsalineflushingandprophylacticenoxaparinoncentralvenouscatheterthrombosisinpicuhospitalizedpediatric AT maryamghodsi effectsofheparinizednormalsalineflushingandprophylacticenoxaparinoncentralvenouscatheterthrombosisinpicuhospitalizedpediatric |