Preclinical pharmaco-toxicological screening of biomimetic melanin-like nanoparticles as a potential therapeutic strategy for cutaneous melanoma

Preclinical pharmaco-toxicological screening of biomimetic melanin-like nanoparticles as a potential therapeutic strategy for cutaneous melanoma

IntroductionDespite its rarity, cutaneous melanoma (CM) represents the deadliest skin cancer with a high mortality rate, an incidence on the rise, and limited therapeutic options at present. Melanin is a polymeric pigment naturally produced within melanocytes and CM cells that gained a noteworthy at...

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Main Authors: Iasmina Marcovici, Raul Chioibas, Istvan Zupko, Iulia Pinzaru, Alina Moaca, Adriana Ledeti, Lucian Barbu-Tudoran, Andreea Geamantan, Iasmina Predescu, Cristina Adriana Dehelean
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Pharmacology
Subjects:
cutaneous melanoma
melanin-like nanoparticles
cytotoxicity
cell migration
epithelial-to-mesenchymal transition
apoptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1487854/full
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