Hypoxia-inducible factor-2α is an essential catabolic regulator of inflammatory rheumatoid arthritis.

Hypoxia-inducible factor-2α is an essential catabolic regulator of inflammatory rheumatoid arthritis.

Rheumatoid arthritis (RA) is a systemic autoimmune disorder that manifests as chronic inflammation and joint tissue destruction. However, the etiology and pathogenesis of RA have not been fully elucidated. Here, we explored the role of the hypoxia-inducible factors (HIFs), HIF-1α (encoded by HIF1A)...

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Main Authors: Je-Hwang Ryu, Chang-Suk Chae, Ji-Sun Kwak, Hwanhee Oh, Youngnim Shin, Yun Hyun Huh, Choong-Gu Lee, Yong-Wook Park, Churl-Hong Chun, Young-Myeong Kim, Sin-Hyeog Im, Jang-Soo Chun
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-06-01
Series:PLoS Biology
Online Access:https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001881&type=printable
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https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001881&type=printable

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