Mouse Nkrp1-Clr gene cluster sequence and expression analyses reveal conservation of tissue-specific MHC-independent immunosurveillance.

Mouse Nkrp1-Clr gene cluster sequence and expression analyses reveal conservation of tissue-specific MHC-independent immunosurveillance.

The Nkrp1 (Klrb1)-Clr (Clec2) genes encode a receptor-ligand system utilized by NK cells as an MHC-independent immunosurveillance strategy for innate immune responses. The related Ly49 family of MHC-I receptors displays extreme allelic polymorphism and haplotype plasticity. In contrast, previous BAC...

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Main Authors: Qiang Zhang, Mir Munir A Rahim, David S J Allan, Megan M Tu, Simon Belanger, Elias Abou-Samra, Jaehun Ma, Harman S Sekhon, Todd Fairhead, Haggag S Zein, James R Carlyle, Stephen K Anderson, Andrew P Makrigiannis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0050561&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0050561&type=printable

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