Glycopeptide Resistance in Gram-Positive Cocci: A Review
Vancomycin-resistant enterococci (VRE) have emerged as important nosocomial pathogens in the past two decades all over the world and have seriously limited the choices available to clinicians for treating infections caused by these agents. Methicillin-resistant Staphylococcus aureus, perhaps the mos...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2012/781679 |
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| author | S. Sujatha Ira Praharaj |
| author_facet | S. Sujatha Ira Praharaj |
| author_sort | S. Sujatha |
| collection | DOAJ |
| description | Vancomycin-resistant enterococci (VRE) have emerged as important nosocomial pathogens in the past two decades all over the world and have seriously limited the choices available to clinicians for treating infections caused by these agents. Methicillin-resistant Staphylococcus aureus, perhaps the most notorious among the nosocomial pathogens, was till recently susceptible to vancomycin and the other glycopeptides. Emergence of vancomycin nonsusceptible strains of S. aureus has led to a worrisome scenario where the options available for treating serious infections due to these organisms are very limited and not well evaluated. Vancomycin resistance in clinically significant isolates of coagulase-negative staphylococci is also on the rise in many setups.
This paper aims to highlight the genetic basis of vancomycin resistance in Enterococcus species and S. aureus. It also focuses on important considerations in detection of vancomycin resistance in these gram-positive bacteria. The problem of glycopeptide resistance in clinical isolates of coagulase-negative staphylococci and the phenomenon of vancomycin tolerance seen in some strains of Streptococcus pneumoniae has also been discussed. Finally, therapeutic options available and being developed against these pathogens have also found a mention. |
| format | Article |
| id | doaj-art-4e60dc38e5da4882bbc08e164263f1ca |
| institution | OA Journals |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-4e60dc38e5da4882bbc08e164263f1ca2025-08-20T02:38:48ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982012-01-01201210.1155/2012/781679781679Glycopeptide Resistance in Gram-Positive Cocci: A ReviewS. Sujatha0Ira Praharaj1Department of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, IndiaDepartment of Microbiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry 605006, IndiaVancomycin-resistant enterococci (VRE) have emerged as important nosocomial pathogens in the past two decades all over the world and have seriously limited the choices available to clinicians for treating infections caused by these agents. Methicillin-resistant Staphylococcus aureus, perhaps the most notorious among the nosocomial pathogens, was till recently susceptible to vancomycin and the other glycopeptides. Emergence of vancomycin nonsusceptible strains of S. aureus has led to a worrisome scenario where the options available for treating serious infections due to these organisms are very limited and not well evaluated. Vancomycin resistance in clinically significant isolates of coagulase-negative staphylococci is also on the rise in many setups. This paper aims to highlight the genetic basis of vancomycin resistance in Enterococcus species and S. aureus. It also focuses on important considerations in detection of vancomycin resistance in these gram-positive bacteria. The problem of glycopeptide resistance in clinical isolates of coagulase-negative staphylococci and the phenomenon of vancomycin tolerance seen in some strains of Streptococcus pneumoniae has also been discussed. Finally, therapeutic options available and being developed against these pathogens have also found a mention.http://dx.doi.org/10.1155/2012/781679 |
| spellingShingle | S. Sujatha Ira Praharaj Glycopeptide Resistance in Gram-Positive Cocci: A Review Interdisciplinary Perspectives on Infectious Diseases |
| title | Glycopeptide Resistance in Gram-Positive Cocci: A Review |
| title_full | Glycopeptide Resistance in Gram-Positive Cocci: A Review |
| title_fullStr | Glycopeptide Resistance in Gram-Positive Cocci: A Review |
| title_full_unstemmed | Glycopeptide Resistance in Gram-Positive Cocci: A Review |
| title_short | Glycopeptide Resistance in Gram-Positive Cocci: A Review |
| title_sort | glycopeptide resistance in gram positive cocci a review |
| url | http://dx.doi.org/10.1155/2012/781679 |
| work_keys_str_mv | AT ssujatha glycopeptideresistanceingrampositivecocciareview AT irapraharaj glycopeptideresistanceingrampositivecocciareview |