Triglyceride-glucose index and its additive interaction with ABCG2/SLC2A9 polygenic risk score on hyperuricemia in middle age and older adults: findings from the DLCC and BHMC study

Triglyceride-glucose index and its additive interaction with ABCG2/SLC2A9 polygenic risk score on hyperuricemia in middle age and older adults: findings from the DLCC and BHMC study

Objective We aim to investigate the joint effect of triglyceride-glucose (TyG) index and polygenic risk scores (PRS) of urate transporter genes ABCG2 and SLC2A9 on hyperuricemia.Methods Baseline data from two prospective population-based cohort studies, including 30,453 individuals aged 50 years or...

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Bibliographic Details
Main Authors: Huijing He, Qiaolu Cheng, Shuo Chen, Qiang Li, Jingbo Zhang, Guangliang Shan, Minying Zhang
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Annals of Medicine
Subjects:
Insulin resistance
triglyceride-glucose index
hyperuricemia
ageing
polygenic risk score
interaction
Online Access:https://www.tandfonline.com/doi/10.1080/07853890.2024.2434186
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