Cohort profile: the Swedish Inception Cohort in inflammatory bowel disease (SIC-IBD)
Purpose There is a need for diagnostic and prognostic biosignatures to improve long-term outcomes in inflammatory bowel disease (IBD). Here, we describe the establishment of the Swedish Inception Cohort in IBD (SIC-IBD) and demonstrate its potential for the identification of such signatures.Particip...
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BMJ Publishing Group
2025-05-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/5/e099218.full |
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| author | Jonas Halfvarson Mauro D’Amato Lena Öhman Carl Eriksson Sven Almer Jan Marsal Åsa V Keita Johan D Söderholm Francesca Bresso Olof Grip Charlotte R H Hedin Daniel Bergemalm Jóhann P Hreinsson Dirk Repsilber Benita Salomon Olle Grännö Hans Strid Adam Carstens Henrik Hjortswang André Blomberg Niloofar Nikaein Shoaib Bakhtyar Carl Mårten Lindqvist Elisabeth Hultgren Hörnquist Maria K Magnusson Marie Carlson Robert Kruse Maria Ling Lundström |
| author_facet | Jonas Halfvarson Mauro D’Amato Lena Öhman Carl Eriksson Sven Almer Jan Marsal Åsa V Keita Johan D Söderholm Francesca Bresso Olof Grip Charlotte R H Hedin Daniel Bergemalm Jóhann P Hreinsson Dirk Repsilber Benita Salomon Olle Grännö Hans Strid Adam Carstens Henrik Hjortswang André Blomberg Niloofar Nikaein Shoaib Bakhtyar Carl Mårten Lindqvist Elisabeth Hultgren Hörnquist Maria K Magnusson Marie Carlson Robert Kruse Maria Ling Lundström |
| author_sort | Jonas Halfvarson |
| collection | DOAJ |
| description | Purpose There is a need for diagnostic and prognostic biosignatures to improve long-term outcomes in inflammatory bowel disease (IBD). Here, we describe the establishment of the Swedish Inception Cohort in IBD (SIC-IBD) and demonstrate its potential for the identification of such signatures.Participants Patients aged ≥18 years with gastrointestinal symptoms who were referred to the gastroenterology unit due to suspected IBD at eight Swedish hospitals between November 2011 and March 2021 were eligible for inclusion.Findings to date In total, 367 patients with IBD (Crohn’s disease, n=142; ulcerative colitis, n=201; IBD-unclassified, n=24) and 168 symptomatic controls were included. In addition, 59 healthy controls without gastrointestinal symptoms were recruited as a second control group. Biospecimens and clinical data were collected at inclusion and in patients with IBD also during follow-up to 10 years. Levels of faecal calprotectin and high-sensitivity C-reactive protein were higher in patients with IBD compared with symptomatic controls and healthy controls. Preliminary results highlight the potential of serum protein signatures and autoantibodies, as well as results from faecal markers, to differentiate between IBD and symptomatic controls in the cohort. During the first year of follow-up, 37% (53/142) of the patients with Crohn’s disease, 24% (48/201) with ulcerative colitis and 4% (1/24) with IBD-U experienced an aggressive disease course.Future plans We have established an inception cohort enabling ongoing initiatives to collect and generate clinical data and multi-omics datasets. The cohort will allow analyses for translation into candidate biosignatures to support clinical decision-making in IBD. Additionally, the data will provide insights into mechanisms of disease pathogenesis. |
| format | Article |
| id | doaj-art-4e5d49ca88d84a8eae4cee4c39edd430 |
| institution | DOAJ |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-4e5d49ca88d84a8eae4cee4c39edd4302025-08-20T03:07:16ZengBMJ Publishing GroupBMJ Open2044-60552025-05-0115510.1136/bmjopen-2025-099218Cohort profile: the Swedish Inception Cohort in inflammatory bowel disease (SIC-IBD)Jonas Halfvarson0Mauro D’Amato1Lena Öhman2Carl Eriksson3Sven Almer4Jan Marsal5Åsa V Keita6Johan D Söderholm7Francesca Bresso8Olof Grip9Charlotte R H Hedin10Daniel Bergemalm11Jóhann P Hreinsson12Dirk Repsilber13Benita Salomon14Olle Grännö15Hans Strid16Adam Carstens17Henrik Hjortswang18André Blomberg19Niloofar Nikaein20Shoaib Bakhtyar21Carl Mårten Lindqvist22Elisabeth Hultgren Hörnquist23Maria K Magnusson24Marie Carlson25Robert Kruse26Maria Ling Lundström273 Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden16 Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain13 Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden3 Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden4 Centre for Digestive Health, Department of Gastroenterology, Dermatovenereology and Rheumatology, Karolinska University Hospital, Stockholm, Sweden11 Department of Gastroenterology, Skåne University Hospital, Malmö/Lund, Sweden14 Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden14 Department of Biomedical and Clinical Sciences, Linköping University, Linköping, SwedenDepartment of Medicine, Karolinska Institutet, Stockholm, Sweden11 Department of Gastroenterology, Skåne University Hospital, Malmö/Lund, Sweden4 Centre for Digestive Health, Department of Gastroenterology, Dermatovenereology and Rheumatology, Karolinska University Hospital, Stockholm, Sweden3 Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden9 Department of Molecular and Clinical Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden1 School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden1 School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden2 Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden4 Centre for Digestive Health, Department of Gastroenterology, Dermatovenereology and Rheumatology, Karolinska University Hospital, Stockholm, Sweden5 Department of Internal Medicine, Ersta Hospital, Stockholm, Sweden7 Department of Gastroenterology, County Council of Östergötland, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden12 Department of Medicine, Geriatrics and Emergency Medicine, Sahlgrenska University Hospital, Östra Hospital, Gothenburg, Sweden1 School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden1 School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden1 School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden1 School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden13 Department of Microbiology and Immunology, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden8 Department of Medical Sciences, Gastroenterology Research Group, Uppsala University, Uppsala, Sweden1 School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden8 Department of Medical Sciences, Gastroenterology Research Group, Uppsala University, Uppsala, SwedenPurpose There is a need for diagnostic and prognostic biosignatures to improve long-term outcomes in inflammatory bowel disease (IBD). Here, we describe the establishment of the Swedish Inception Cohort in IBD (SIC-IBD) and demonstrate its potential for the identification of such signatures.Participants Patients aged ≥18 years with gastrointestinal symptoms who were referred to the gastroenterology unit due to suspected IBD at eight Swedish hospitals between November 2011 and March 2021 were eligible for inclusion.Findings to date In total, 367 patients with IBD (Crohn’s disease, n=142; ulcerative colitis, n=201; IBD-unclassified, n=24) and 168 symptomatic controls were included. In addition, 59 healthy controls without gastrointestinal symptoms were recruited as a second control group. Biospecimens and clinical data were collected at inclusion and in patients with IBD also during follow-up to 10 years. Levels of faecal calprotectin and high-sensitivity C-reactive protein were higher in patients with IBD compared with symptomatic controls and healthy controls. Preliminary results highlight the potential of serum protein signatures and autoantibodies, as well as results from faecal markers, to differentiate between IBD and symptomatic controls in the cohort. During the first year of follow-up, 37% (53/142) of the patients with Crohn’s disease, 24% (48/201) with ulcerative colitis and 4% (1/24) with IBD-U experienced an aggressive disease course.Future plans We have established an inception cohort enabling ongoing initiatives to collect and generate clinical data and multi-omics datasets. The cohort will allow analyses for translation into candidate biosignatures to support clinical decision-making in IBD. Additionally, the data will provide insights into mechanisms of disease pathogenesis.https://bmjopen.bmj.com/content/15/5/e099218.full |
| spellingShingle | Jonas Halfvarson Mauro D’Amato Lena Öhman Carl Eriksson Sven Almer Jan Marsal Åsa V Keita Johan D Söderholm Francesca Bresso Olof Grip Charlotte R H Hedin Daniel Bergemalm Jóhann P Hreinsson Dirk Repsilber Benita Salomon Olle Grännö Hans Strid Adam Carstens Henrik Hjortswang André Blomberg Niloofar Nikaein Shoaib Bakhtyar Carl Mårten Lindqvist Elisabeth Hultgren Hörnquist Maria K Magnusson Marie Carlson Robert Kruse Maria Ling Lundström Cohort profile: the Swedish Inception Cohort in inflammatory bowel disease (SIC-IBD) BMJ Open |
| title | Cohort profile: the Swedish Inception Cohort in inflammatory bowel disease (SIC-IBD) |
| title_full | Cohort profile: the Swedish Inception Cohort in inflammatory bowel disease (SIC-IBD) |
| title_fullStr | Cohort profile: the Swedish Inception Cohort in inflammatory bowel disease (SIC-IBD) |
| title_full_unstemmed | Cohort profile: the Swedish Inception Cohort in inflammatory bowel disease (SIC-IBD) |
| title_short | Cohort profile: the Swedish Inception Cohort in inflammatory bowel disease (SIC-IBD) |
| title_sort | cohort profile the swedish inception cohort in inflammatory bowel disease sic ibd |
| url | https://bmjopen.bmj.com/content/15/5/e099218.full |
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