Comparison of methods to handle missing values in a continuous index test in a diagnostic accuracy study – a simulation study

Comparison of methods to handle missing values in a continuous index test in a diagnostic accuracy study – a simulation study

Abstract Background Most diagnostic accuracy studies have applied a complete case analysis (CCA) or single imputation approach to address missing values in the index test, which may lead to biased results. Therefore, this simulation study aims to compare the performance of different methods in estim...

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Bibliographic Details
Main Authors: Katharina Stahlmann, Bastiaan Kellerhuis, Johannes B. Reitsma, Nandini Dendukuri, Antonia Zapf
Format: Article
Language:English
Published: BMC 2025-05-01
Series:BMC Medical Research Methodology
Subjects:
Missing values
Diagnostic study
Index test
AUC
Simulation study
Neutral comparison study
Online Access:https://doi.org/10.1186/s12874-025-02594-2
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https://doi.org/10.1186/s12874-025-02594-2

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