Next-Generation Approaches in Sports Medicine: The Role of Genetics, Omics, and Digital Health in Optimizing Athlete Performance and Longevity—A Narrative Review
This review aims to provide a comprehensive framework for implementing precision sports medicine, integrating genetics, pharmacogenomics, digital health solutions, and multi-omics data. Literature review was conducted using MEDLINE, EMBASE, Web of Science, and Cochrane Library databases (January 201...
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2025-06-01
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| author | Alen Juginović Adrijana Kekić Ivan Aranza Valentina Biloš Mirko Armanda |
| author_facet | Alen Juginović Adrijana Kekić Ivan Aranza Valentina Biloš Mirko Armanda |
| author_sort | Alen Juginović |
| collection | DOAJ |
| description | This review aims to provide a comprehensive framework for implementing precision sports medicine, integrating genetics, pharmacogenomics, digital health solutions, and multi-omics data. Literature review was conducted using MEDLINE, EMBASE, Web of Science, and Cochrane Library databases (January 2018–April 2024), focusing on precision medicine applications in sports medicine, utilizing key terms including “precision medicine”, “sports medicine”, “genetics”, and “multi-omics”, with forward and backward citation tracking. The review identified key gene variants affecting athletic performance: endurance (<i>AMPD1</i>, <i>PPARGC1A</i>), power (<i>ACTN3</i>, <i>NOS3</i>), strength (<i>PPARG</i>), and injury susceptibility (<i>COL5A1</i>, <i>MMP3</i>), while also examining inherited conditions like cardiomyopathies (<i>MYH7</i>, <i>MYBPC3</i>). Pharmacogenomic guidelines were established for optimizing common sports medications, including NSAIDs (<i>CYP2C9</i>), opioids (<i>CYP2D6</i>), and cardiovascular drugs (<i>SLCO1B1</i>, <i>CYP2C19</i>). Digital health technologies, including wearables and predictive analytics, showed potential for enhanced athlete monitoring and injury prevention, while multi-omics approaches integrated various molecular data to understand exercise capacity and injury predisposition, enabling personalized assessments, training regimens, and therapeutic interventions based on individual biomolecular profiles. This review provides sports medicine professionals with a framework to deliver personalized care tailored to each athlete’s unique profile, promising optimized performance, reduced injury risks, and improved recovery outcomes. |
| format | Article |
| id | doaj-art-4e4fccb74e324bceb2ecde56788fd8a5 |
| institution | DOAJ |
| issn | 2075-1729 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj-art-4e4fccb74e324bceb2ecde56788fd8a52025-08-20T02:45:53ZengMDPI AGLife2075-17292025-06-01157102310.3390/life15071023Next-Generation Approaches in Sports Medicine: The Role of Genetics, Omics, and Digital Health in Optimizing Athlete Performance and Longevity—A Narrative ReviewAlen Juginović0Adrijana Kekić1Ivan Aranza2Valentina Biloš3Mirko Armanda4Department of Neurobiology, Harvard Medical School, 220 Longwood Avenue, Boston, MA 02115, USADepartment of Pharmacy, Mayo Clinic Arizona, 5777 E Mayo Blvd, Phoenix, AZ 85054, USADepartment of Cardiology, University Hospital Split, Spinčićeva 1, 21000 Split, CroatiaInstitute of Emergency Medicine of the Zagreb County, Radićev Odvojak 58, 10410 Velika Gorica, CroatiaSchool of Medicine, University of Split, Šoltanska 2, 21000 Split, CroatiaThis review aims to provide a comprehensive framework for implementing precision sports medicine, integrating genetics, pharmacogenomics, digital health solutions, and multi-omics data. Literature review was conducted using MEDLINE, EMBASE, Web of Science, and Cochrane Library databases (January 2018–April 2024), focusing on precision medicine applications in sports medicine, utilizing key terms including “precision medicine”, “sports medicine”, “genetics”, and “multi-omics”, with forward and backward citation tracking. The review identified key gene variants affecting athletic performance: endurance (<i>AMPD1</i>, <i>PPARGC1A</i>), power (<i>ACTN3</i>, <i>NOS3</i>), strength (<i>PPARG</i>), and injury susceptibility (<i>COL5A1</i>, <i>MMP3</i>), while also examining inherited conditions like cardiomyopathies (<i>MYH7</i>, <i>MYBPC3</i>). Pharmacogenomic guidelines were established for optimizing common sports medications, including NSAIDs (<i>CYP2C9</i>), opioids (<i>CYP2D6</i>), and cardiovascular drugs (<i>SLCO1B1</i>, <i>CYP2C19</i>). Digital health technologies, including wearables and predictive analytics, showed potential for enhanced athlete monitoring and injury prevention, while multi-omics approaches integrated various molecular data to understand exercise capacity and injury predisposition, enabling personalized assessments, training regimens, and therapeutic interventions based on individual biomolecular profiles. This review provides sports medicine professionals with a framework to deliver personalized care tailored to each athlete’s unique profile, promising optimized performance, reduced injury risks, and improved recovery outcomes.https://www.mdpi.com/2075-1729/15/7/1023precision sports medicinegenomicspharmacogenomicsmulti-omicsdigital health |
| spellingShingle | Alen Juginović Adrijana Kekić Ivan Aranza Valentina Biloš Mirko Armanda Next-Generation Approaches in Sports Medicine: The Role of Genetics, Omics, and Digital Health in Optimizing Athlete Performance and Longevity—A Narrative Review Life precision sports medicine genomics pharmacogenomics multi-omics digital health |
| title | Next-Generation Approaches in Sports Medicine: The Role of Genetics, Omics, and Digital Health in Optimizing Athlete Performance and Longevity—A Narrative Review |
| title_full | Next-Generation Approaches in Sports Medicine: The Role of Genetics, Omics, and Digital Health in Optimizing Athlete Performance and Longevity—A Narrative Review |
| title_fullStr | Next-Generation Approaches in Sports Medicine: The Role of Genetics, Omics, and Digital Health in Optimizing Athlete Performance and Longevity—A Narrative Review |
| title_full_unstemmed | Next-Generation Approaches in Sports Medicine: The Role of Genetics, Omics, and Digital Health in Optimizing Athlete Performance and Longevity—A Narrative Review |
| title_short | Next-Generation Approaches in Sports Medicine: The Role of Genetics, Omics, and Digital Health in Optimizing Athlete Performance and Longevity—A Narrative Review |
| title_sort | next generation approaches in sports medicine the role of genetics omics and digital health in optimizing athlete performance and longevity a narrative review |
| topic | precision sports medicine genomics pharmacogenomics multi-omics digital health |
| url | https://www.mdpi.com/2075-1729/15/7/1023 |
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