Uncovering hidden enhancers through unbiased in vivo testing

Uncovering hidden enhancers through unbiased in vivo testing

Abstract Chromatin signatures are widely used to identify tissue-specific in vivo enhancers, but their sensitivity and specificity remains unclear. Here we show that many developmental enhancers remain undetectable using currently available chromatin data. In an initial comparison of over 1200 devel...

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Main Authors: Brandon J. Mannion, Stella Tran, Ingrid Plajzer-Frick, Catherine S. Novak, Veena Afzal, Jennifer A. Akiyama, Ismael Sospedra-Arrufat, Sarah Barton, Erik Beckman, Tyler H. Garvin, Patrick Godfrey, Janeth Godoy, Riana D. Hunter, Momoe Kato, Michael Kosicki, Anne N. Kronshage, Elizabeth A. Lee, Eman M. Meky, Quan T. Pham, Kianna von Maydell, Yiwen Zhu, Javier Lopez-Rios, Diane E. Dickel, Marco Osterwalder, Axel Visel, Len A. Pennacchio
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62497-0
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