Mechanical stress facilitates calcium influx and growth of alveolar epithelial cells via activation of the BDKRB1/Ca2+/CaMKII/MEK1/ERK axis

Mechanical stress facilitates calcium influx and growth of alveolar epithelial cells via activation of the BDKRB1/Ca2+/CaMKII/MEK1/ERK axis

Abstract Background Mechanical stress and calcium metabolism are associated with lung development and various pulmonary diseases. Our previous research demonstrated that BDKRB1/Ca2+ signal transduction may be involved in lung dysplasia resulting from scoliosis and thoracic insufficiency. Therefore,...

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Bibliographic Details
Main Authors: Ying Zhang, Qing-dong Zhang, Quan Li, Zhi-yue Shi, Cheng Pan, Rong-shuang Yan, De-rui Fei, Shi-xin Xu, Yang Luo
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Respiratory Research
Subjects:
Alveolar epithelial cells
Mechanical stress
Calcium
Growth
Bradykinin receptor B1
Online Access:https://doi.org/10.1186/s12931-025-03240-7
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