Meta-analysis of the efficacy of camel milk consumption for improving autism symptoms in children in randomized clinical trials
Background: Camel milk has emerged as a potential complementary therapy for autism spectrum disorder (ASD). Aim: This study aimed to gather evidence from randomized controlled trials (RCTs) on the effectiveness of camel milk consumption in improving symptoms and associated measures in children wi...
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| Format: | Article |
| Language: | English |
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Tripoli University
2024-09-01
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| Series: | Open Veterinary Journal |
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| Online Access: | https://www.openveterinaryjournal.com/?mno=206445 |
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| author | Mahmoud Kandeel Mohamed A. Morsy Khalid M. Al Khodair Sameer Alhojaily |
| author_facet | Mahmoud Kandeel Mohamed A. Morsy Khalid M. Al Khodair Sameer Alhojaily |
| author_sort | Mahmoud Kandeel |
| collection | DOAJ |
| description | Background:
Camel milk has emerged as a potential complementary therapy for autism spectrum disorder (ASD).
Aim:
This study aimed to gather evidence from randomized controlled trials (RCTs) on the effectiveness of camel milk consumption in improving symptoms and associated measures in children with ASD.
Methods:
Comprehensive searches of multiple databases were conducted up to March 14, 2024, for RCTs that had evaluated whether camel milk consumption by children with ASD was more beneficial than the consumption of a control substance. Quality and bias analyses and meta-anlaysis data were synthesized and analyzed.
Results:
Of 136 records identified, 5 RCTs (n = 299 children) were selected. The mean difference in scores on the Childhood Autism Rating Scale (CARS) for the group given camel milk and the control groups was a mean deviation (MD) ‒0.75, 95% CI ‒1.97 to 0.47, p = .23. The mean difference in CARS scores in the subgroup analyses for raw camel milk was MD ‒0.95, 95% CI ‒2.33 to 0.44, p = .18 and boiled camel milk MD ‒0.50, 95% CI ‒1.93 to 0.93, p = .49. A qualitative synthesis found that raw camel milk intake led to improvements in various social behaviors in children with ASD. Camel milk consumption resulted in increased levels of anti-inflammatory, antioxidant, and immunomodulatory biomarkers, with some differences observed between patients given raw camel milk and boiled camel milk.
Conclusion:
Camel milk shows promise in improving social behaviors and certain biochemical markers in children with ASD, although the current meta-analysis did not document a significant statistical difference in CARS scores for the children studied. Future studies should focus on rigorous RCTs and larger sample sizes to substantiate these preliminary findings. [Open Vet J 2024; 14(9.000): 2441-2452] |
| format | Article |
| id | doaj-art-4e482d94c8db4f8c9e587e19beb4a2bf |
| institution | OA Journals |
| issn | 2226-4485 2218-6050 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Tripoli University |
| record_format | Article |
| series | Open Veterinary Journal |
| spelling | doaj-art-4e482d94c8db4f8c9e587e19beb4a2bf2025-08-20T01:47:36ZengTripoli UniversityOpen Veterinary Journal2226-44852218-60502024-09-011492441245210.5455/OVJ.2024.v14.i9.33206445Meta-analysis of the efficacy of camel milk consumption for improving autism symptoms in children in randomized clinical trialsMahmoud Kandeel0Mohamed A. Morsy1Khalid M. Al Khodair2Sameer Alhojaily3King Faisal University King Faisal University King Faisal University King Faisal UniversityBackground: Camel milk has emerged as a potential complementary therapy for autism spectrum disorder (ASD). Aim: This study aimed to gather evidence from randomized controlled trials (RCTs) on the effectiveness of camel milk consumption in improving symptoms and associated measures in children with ASD. Methods: Comprehensive searches of multiple databases were conducted up to March 14, 2024, for RCTs that had evaluated whether camel milk consumption by children with ASD was more beneficial than the consumption of a control substance. Quality and bias analyses and meta-anlaysis data were synthesized and analyzed. Results: Of 136 records identified, 5 RCTs (n = 299 children) were selected. The mean difference in scores on the Childhood Autism Rating Scale (CARS) for the group given camel milk and the control groups was a mean deviation (MD) ‒0.75, 95% CI ‒1.97 to 0.47, p = .23. The mean difference in CARS scores in the subgroup analyses for raw camel milk was MD ‒0.95, 95% CI ‒2.33 to 0.44, p = .18 and boiled camel milk MD ‒0.50, 95% CI ‒1.93 to 0.93, p = .49. A qualitative synthesis found that raw camel milk intake led to improvements in various social behaviors in children with ASD. Camel milk consumption resulted in increased levels of anti-inflammatory, antioxidant, and immunomodulatory biomarkers, with some differences observed between patients given raw camel milk and boiled camel milk. Conclusion: Camel milk shows promise in improving social behaviors and certain biochemical markers in children with ASD, although the current meta-analysis did not document a significant statistical difference in CARS scores for the children studied. Future studies should focus on rigorous RCTs and larger sample sizes to substantiate these preliminary findings. [Open Vet J 2024; 14(9.000): 2441-2452]https://www.openveterinaryjournal.com/?mno=206445autism spectrum disordercamel milkmeta-analysistherapeutic interventionchildhood autism rating scale |
| spellingShingle | Mahmoud Kandeel Mohamed A. Morsy Khalid M. Al Khodair Sameer Alhojaily Meta-analysis of the efficacy of camel milk consumption for improving autism symptoms in children in randomized clinical trials Open Veterinary Journal autism spectrum disorder camel milk meta-analysis therapeutic intervention childhood autism rating scale |
| title | Meta-analysis of the efficacy of camel milk consumption for improving autism symptoms in children in randomized clinical trials |
| title_full | Meta-analysis of the efficacy of camel milk consumption for improving autism symptoms in children in randomized clinical trials |
| title_fullStr | Meta-analysis of the efficacy of camel milk consumption for improving autism symptoms in children in randomized clinical trials |
| title_full_unstemmed | Meta-analysis of the efficacy of camel milk consumption for improving autism symptoms in children in randomized clinical trials |
| title_short | Meta-analysis of the efficacy of camel milk consumption for improving autism symptoms in children in randomized clinical trials |
| title_sort | meta analysis of the efficacy of camel milk consumption for improving autism symptoms in children in randomized clinical trials |
| topic | autism spectrum disorder camel milk meta-analysis therapeutic intervention childhood autism rating scale |
| url | https://www.openveterinaryjournal.com/?mno=206445 |
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