Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation
There are numerous evaluations of natural products, of which majority are food bioactives, performed up to date for their various health beneficial activities via targeting specific proteins. However, the direct identification of a targeted protein remains unexplored for natural occurring compounds....
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| Format: | Article |
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Tsinghua University Press
2022-03-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021000951 |
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| author | Guliang Yang Haiyan Zhong Xinxin Xia Zhiwen Qi Chengzhang Wang Shiming Li |
| author_facet | Guliang Yang Haiyan Zhong Xinxin Xia Zhiwen Qi Chengzhang Wang Shiming Li |
| author_sort | Guliang Yang |
| collection | DOAJ |
| description | There are numerous evaluations of natural products, of which majority are food bioactives, performed up to date for their various health beneficial activities via targeting specific proteins. However, the direct identification of a targeted protein remains unexplored for natural occurring compounds. Proteolysis targeting chimera (PROTAC) is a type of bifunctional chimeric molecules that can directly degrade the binding proteins targeted by bioactive molecules in an ubiquitin-proteasome pathway. As the agents in protein degradation dependent on ubiquitin ligase, the bifunctional molecule connects the target protein ligand and E3 ligase ligand together via an appropriate linker. It is highly selective and efficient to induce the ubiquitin-mediated degradation of targeted binding proteins. Therefore, it has been demonstrated that the PROTAC technology has broad application in the modulation of the target protein level. In this review, we outlined the advances in PROTAC combined molecule compounds, summarized its quantitative structure-activity relationship, and finally reviewed the methods applied in identifying the target proteins of natural products. We hope it will provide an insightful application of PROTAC techniques in the target protein identification of natural products including food bioactive molecules. |
| format | Article |
| id | doaj-art-4e3b3fa7827c47bb94ef853f8ea1da52 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2022-03-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-4e3b3fa7827c47bb94ef853f8ea1da522025-02-03T05:21:16ZengTsinghua University PressFood Science and Human Wellness2213-45302022-03-01112199207Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradationGuliang Yang0Haiyan Zhong1Xinxin Xia2Zhiwen Qi3Chengzhang Wang4Shiming Li5National Engineering Laboratory for Rice and By-products Processing, Food Science and Engineering College, Central South University of Forestry and Technology, Changsha 410004, ChinaNational Engineering Laboratory for Rice and By-products Processing, Food Science and Engineering College, Central South University of Forestry and Technology, Changsha 410004, ChinaNational Engineering Laboratory for Rice and By-products Processing, Food Science and Engineering College, Central South University of Forestry and Technology, Changsha 410004, ChinaInstitute of Chemical Industry of Forest Products, CAF, Nanjing 210042, China; Corresponding author.Institute of Chemical Industry of Forest Products, CAF, Nanjing 210042, ChinaHubei Key Laboratory of Economic Forest Germplasm Improvement and Resources Comprehensive Utilization, Huanggang Normal University, Huanggang 438000, China; Corresponding author.There are numerous evaluations of natural products, of which majority are food bioactives, performed up to date for their various health beneficial activities via targeting specific proteins. However, the direct identification of a targeted protein remains unexplored for natural occurring compounds. Proteolysis targeting chimera (PROTAC) is a type of bifunctional chimeric molecules that can directly degrade the binding proteins targeted by bioactive molecules in an ubiquitin-proteasome pathway. As the agents in protein degradation dependent on ubiquitin ligase, the bifunctional molecule connects the target protein ligand and E3 ligase ligand together via an appropriate linker. It is highly selective and efficient to induce the ubiquitin-mediated degradation of targeted binding proteins. Therefore, it has been demonstrated that the PROTAC technology has broad application in the modulation of the target protein level. In this review, we outlined the advances in PROTAC combined molecule compounds, summarized its quantitative structure-activity relationship, and finally reviewed the methods applied in identifying the target proteins of natural products. We hope it will provide an insightful application of PROTAC techniques in the target protein identification of natural products including food bioactive molecules.http://www.sciencedirect.com/science/article/pii/S2213453021000951PROTACLigandNatural productsTarget binding |
| spellingShingle | Guliang Yang Haiyan Zhong Xinxin Xia Zhiwen Qi Chengzhang Wang Shiming Li Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation Food Science and Human Wellness PROTAC Ligand Natural products Target binding |
| title | Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation |
| title_full | Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation |
| title_fullStr | Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation |
| title_full_unstemmed | Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation |
| title_short | Potential application of proteolysis targeting chimera (PROTAC) modification technology in natural products for their targeted protein degradation |
| title_sort | potential application of proteolysis targeting chimera protac modification technology in natural products for their targeted protein degradation |
| topic | PROTAC Ligand Natural products Target binding |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021000951 |
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