eIF5A maintains intestinal epithelial homeostasis by sustaining intestinal stem cells

eIF5A maintains intestinal epithelial homeostasis by sustaining intestinal stem cells

Abstract Intestinal homeostasis is sustained by self-renewal of intestinal stem cells (ISCs), which continuously divide and produce proliferative transit-amplifying (TA) and then progenitor cells. Eukaryotic translation initiation factor 5A (eIF5A), a conserved translation factor, involves in a vari...

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Bibliographic Details
Main Authors: Leilei Li, Yanhui Xiao, Liansheng Liu, Qianying Zhang, Yong Zhang, Dahai Zhu, Ye-Guang Chen
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:Cell Regeneration
Subjects:
Intestinal homeostasis
eIF5A
Intestinal stem cells
Mitochondrial translation
Online Access:https://doi.org/10.1186/s13619-025-00243-z
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