Synthesis, Characterization, and Osteoblastic Cell Culture of Poly(L-co-D,L-lactide-co-trimethylene carbonate) Scaffolds
Lactide-based polymers have been widely investigated as materials for tissue engineering. However, characteristics such as low flexibility and elongation tend to limit particular applications, although these can be enhanced by adding plasticizers such as trimethylene carbonate (TMC) to the polymer c...
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2014/501789 |
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| author | André Dutra Messias Kelly Fernanda Martins Adriana Cristina Motta Eliana Aparecida de Rezende Duek |
| author_facet | André Dutra Messias Kelly Fernanda Martins Adriana Cristina Motta Eliana Aparecida de Rezende Duek |
| author_sort | André Dutra Messias |
| collection | DOAJ |
| description | Lactide-based polymers have been widely investigated as materials for tissue engineering. However, characteristics such as low flexibility and elongation tend to limit particular applications, although these can be enhanced by adding plasticizers such as trimethylene carbonate (TMC) to the polymer chain of the copolymer poly(L-lactide-co-D,L-lactide) (PLDLA). The aim of this work was to synthesize and characterize a terpolymer of L-lactide, D,L-lactide, and TMC. The polymers were synthesized from 30% TMC by bulk polymerization and resulted in an average molar mass >105 g/mol. Thermal investigation of PLDLA-TMC showed a decrease in the glass transition and onset temperatures compared to PLDLA. PLDLA-TMC scaffolds stimulated the proliferation and normal phenotypic manifestations of cultured osteoblasts. These results show that it was possible to produce a terpolymer from L-lactide, D,L-lactide, and TMC. Scaffolds of this terpolymer had important characteristics that could be useful for applications in bone tissue engineering. |
| format | Article |
| id | doaj-art-4e2baf69b2a649ebbc4eec64fa2308b3 |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-4e2baf69b2a649ebbc4eec64fa2308b32025-02-03T01:23:51ZengWileyInternational Journal of Biomaterials1687-87871687-87952014-01-01201410.1155/2014/501789501789Synthesis, Characterization, and Osteoblastic Cell Culture of Poly(L-co-D,L-lactide-co-trimethylene carbonate) ScaffoldsAndré Dutra Messias0Kelly Fernanda Martins1Adriana Cristina Motta2Eliana Aparecida de Rezende Duek3Department of Materials Engineering, Faculty of Mechanical Engineering, State University of Campinas, Rua Mendeleyev 200, 13083-860 Campinas, SP, BrazilLaboratory of Biomaterials, Faculty of Medical Sciences and Health, Pontifical Catholic University of São Paulo, Rua Joubert Wey 290, 18030-070 Sorocaba, SP, BrazilLaboratory of Biomaterials, Faculty of Medical Sciences and Health, Pontifical Catholic University of São Paulo, Rua Joubert Wey 290, 18030-070 Sorocaba, SP, BrazilDepartment of Materials Engineering, Faculty of Mechanical Engineering, State University of Campinas, Rua Mendeleyev 200, 13083-860 Campinas, SP, BrazilLactide-based polymers have been widely investigated as materials for tissue engineering. However, characteristics such as low flexibility and elongation tend to limit particular applications, although these can be enhanced by adding plasticizers such as trimethylene carbonate (TMC) to the polymer chain of the copolymer poly(L-lactide-co-D,L-lactide) (PLDLA). The aim of this work was to synthesize and characterize a terpolymer of L-lactide, D,L-lactide, and TMC. The polymers were synthesized from 30% TMC by bulk polymerization and resulted in an average molar mass >105 g/mol. Thermal investigation of PLDLA-TMC showed a decrease in the glass transition and onset temperatures compared to PLDLA. PLDLA-TMC scaffolds stimulated the proliferation and normal phenotypic manifestations of cultured osteoblasts. These results show that it was possible to produce a terpolymer from L-lactide, D,L-lactide, and TMC. Scaffolds of this terpolymer had important characteristics that could be useful for applications in bone tissue engineering.http://dx.doi.org/10.1155/2014/501789 |
| spellingShingle | André Dutra Messias Kelly Fernanda Martins Adriana Cristina Motta Eliana Aparecida de Rezende Duek Synthesis, Characterization, and Osteoblastic Cell Culture of Poly(L-co-D,L-lactide-co-trimethylene carbonate) Scaffolds International Journal of Biomaterials |
| title | Synthesis, Characterization, and Osteoblastic Cell Culture of Poly(L-co-D,L-lactide-co-trimethylene carbonate) Scaffolds |
| title_full | Synthesis, Characterization, and Osteoblastic Cell Culture of Poly(L-co-D,L-lactide-co-trimethylene carbonate) Scaffolds |
| title_fullStr | Synthesis, Characterization, and Osteoblastic Cell Culture of Poly(L-co-D,L-lactide-co-trimethylene carbonate) Scaffolds |
| title_full_unstemmed | Synthesis, Characterization, and Osteoblastic Cell Culture of Poly(L-co-D,L-lactide-co-trimethylene carbonate) Scaffolds |
| title_short | Synthesis, Characterization, and Osteoblastic Cell Culture of Poly(L-co-D,L-lactide-co-trimethylene carbonate) Scaffolds |
| title_sort | synthesis characterization and osteoblastic cell culture of poly l co d l lactide co trimethylene carbonate scaffolds |
| url | http://dx.doi.org/10.1155/2014/501789 |
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