Neurobiology of Vascular Dementia
Vascular dementia is, in its current conceptual form, a distinct type of dementia with a spectrum of specific clinical and pathophysiological features. However, in a very large majority of cases, these alterations occur in an already aged brain, characterized by a milieu of cellular and molecular ev...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Journal of Aging Research |
| Online Access: | http://dx.doi.org/10.4061/2011/401604 |
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| _version_ | 1832552354166079488 |
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| author | Ana-Maria Enciu Stefan N. Constantinescu Laurenţiu M. Popescu Dafin F. Mureşanu Bogdan O. Popescu |
| author_facet | Ana-Maria Enciu Stefan N. Constantinescu Laurenţiu M. Popescu Dafin F. Mureşanu Bogdan O. Popescu |
| author_sort | Ana-Maria Enciu |
| collection | DOAJ |
| description | Vascular dementia is, in its current conceptual form, a distinct type of dementia with a spectrum of specific clinical and pathophysiological features. However, in a very large majority of cases, these alterations occur in an already aged brain, characterized by a milieu of cellular and molecular events common for different neurodegenerative diseases. The cell signaling defects and molecular dyshomeostasis might lead to neuronal malfunction prior to the death of neurons and the alteration of neuronal networks. In the present paper, we explore some of the molecular mechanisms underlying brain malfunction triggered by cerebrovascular disease and risk factors. We suggest that, in the age of genetic investigation and molecular diagnosis, the concept of vascular dementia needs a new approach. |
| format | Article |
| id | doaj-art-4e28c9a6331341d58b895e6940cae4d7 |
| institution | Kabale University |
| issn | 2090-2212 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Aging Research |
| spelling | doaj-art-4e28c9a6331341d58b895e6940cae4d72025-02-03T05:58:48ZengWileyJournal of Aging Research2090-22122011-01-01201110.4061/2011/401604401604Neurobiology of Vascular DementiaAna-Maria Enciu0Stefan N. Constantinescu1Laurenţiu M. Popescu2Dafin F. Mureşanu3Bogdan O. Popescu4Department of Cellular and Molecular Medicine, School of Medicine, “Carol Davila” University of Medicine and Pharmacy, 8 Eroilor Sanitari, Sector 5, 050474 Bucharest, RomaniaDepartment of Cellular and Molecular Medicine, School of Medicine, “Carol Davila” University of Medicine and Pharmacy, 8 Eroilor Sanitari, Sector 5, 050474 Bucharest, RomaniaDepartment of Cellular and Molecular Medicine, School of Medicine, “Carol Davila” University of Medicine and Pharmacy, 8 Eroilor Sanitari, Sector 5, 050474 Bucharest, RomaniaDepartment of Neurology, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8 Victor Babeş, 400023 Cluj-Napoca, RomaniaLaboratory of Molecular Medicine, “Victor Babeş” National Institute of Pathology, 99-101 Splaiul Independenţei, Sector 5, 050096 Bucharest, RomaniaVascular dementia is, in its current conceptual form, a distinct type of dementia with a spectrum of specific clinical and pathophysiological features. However, in a very large majority of cases, these alterations occur in an already aged brain, characterized by a milieu of cellular and molecular events common for different neurodegenerative diseases. The cell signaling defects and molecular dyshomeostasis might lead to neuronal malfunction prior to the death of neurons and the alteration of neuronal networks. In the present paper, we explore some of the molecular mechanisms underlying brain malfunction triggered by cerebrovascular disease and risk factors. We suggest that, in the age of genetic investigation and molecular diagnosis, the concept of vascular dementia needs a new approach.http://dx.doi.org/10.4061/2011/401604 |
| spellingShingle | Ana-Maria Enciu Stefan N. Constantinescu Laurenţiu M. Popescu Dafin F. Mureşanu Bogdan O. Popescu Neurobiology of Vascular Dementia Journal of Aging Research |
| title | Neurobiology of Vascular Dementia |
| title_full | Neurobiology of Vascular Dementia |
| title_fullStr | Neurobiology of Vascular Dementia |
| title_full_unstemmed | Neurobiology of Vascular Dementia |
| title_short | Neurobiology of Vascular Dementia |
| title_sort | neurobiology of vascular dementia |
| url | http://dx.doi.org/10.4061/2011/401604 |
| work_keys_str_mv | AT anamariaenciu neurobiologyofvasculardementia AT stefannconstantinescu neurobiologyofvasculardementia AT laurentiumpopescu neurobiologyofvasculardementia AT dafinfmuresanu neurobiologyofvasculardementia AT bogdanopopescu neurobiologyofvasculardementia |