Cumulative Impact Loading and Cartilage Synthesis Biomarkers May Be Associated With Injury Risk in Female Collegiate Basketball Players
Purpose: To evaluate whether cumulative impact load and serum biomarkers are related to lower-extremity injury and to determine any impact load and cartilage biomarker relationships in collegiate female basketball athletes. Methods: This was a prospective longitudinal study evaluating lower-extremit...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Arthroscopy, Sports Medicine, and Rehabilitation |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666061X24001299 |
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| author | Julie P. Burland, Ph.D., A.T.C., C.S.C.S. Michael Szymanski, Ph.D., A.T.C. Jeb Struder, Ph.D. Margaret Morrissey, Ph.D. Michelle Van Dyke, Ph.D. Christian Lattermann, M.D. Janelle Francisco, M.S., A.T.C. Cory M. Edgar, M.D., Ph.D. |
| author_facet | Julie P. Burland, Ph.D., A.T.C., C.S.C.S. Michael Szymanski, Ph.D., A.T.C. Jeb Struder, Ph.D. Margaret Morrissey, Ph.D. Michelle Van Dyke, Ph.D. Christian Lattermann, M.D. Janelle Francisco, M.S., A.T.C. Cory M. Edgar, M.D., Ph.D. |
| author_sort | Julie P. Burland, Ph.D., A.T.C., C.S.C.S. |
| collection | DOAJ |
| description | Purpose: To evaluate whether cumulative impact load and serum biomarkers are related to lower-extremity injury and to determine any impact load and cartilage biomarker relationships in collegiate female basketball athletes. Methods: This was a prospective longitudinal study evaluating lower-extremity impact load, serum cartilage biomarkers, and injury incidence over the course of a single collegiate women’s basketball season. Data were collected from August 2022 to April 2023; no other follow-up after the cessation of the season was conducted in this cohort. Inclusion criteria for the study included collegiate women’s basketball athletes, ages 18 to 25 years, who were noninjured at the start of the study time frame (August 2024). Cartilage synthesis (procollagen II carboxy propeptide and aggrecan chondroitin sulfate 846 epitope) and degradation (collagen type II cleavage) biomarkers were evaluated at 6 season timepoints. Impact load metrics (cumulative bone stimulus, impact intensity) were collected during practices using inertial measurement units secured to the distal medial tibiae. Injury was defined as restriction of participation for 1 or more days beyond day of initial injury. Cumulative impact load metrics were calculated over the week before any documented injury and blood draws for analysis. Point biserial and Pearson product moment correlations were used to determine the relationship between impact load metrics, serum biomarkers, and injury. Results: Eleven collegiate women’s basketball athletes (height: 1.86 meters, mass: 82.0 kg, age: 20.54 years) participated. Greater medium-range (6-20 g) cumulative impact intensities during week 5 and 6 for both limbs (r = 0.674, P = .023) and high-range (20-200 g) during week 8 for both limbs (0.672, P = .024) were associated with injury. Greater cumulative bone stimulus was associated with increased procollagen II carboxy propeptide levels before conference playoffs for right (r = 0.694, P = .026) and left (r = 0.747, P = .013) limbs. Greater chondroitin sulfate 846 epitope levels at off-season-1 (r = 0.729, P = .017), and at the beginning of the competitive season (r = 0.645, P = .044) were associated with season-long injury incidence. Conclusions: In this study, we found that moderate-to-high intensity impacts (6-200 g) early in the season were associated with subsequent injury among female collegiate basketball players. Increased cartilage synthesis at various time points was correlated with increased cumulative bone stimulus metrics and season-long injury incidence in this population. Level of Evidence: Level IV, prognostic case series. |
| format | Article |
| id | doaj-art-4e1bf28787f74c8b9cd23e06ab78dcdf |
| institution | OA Journals |
| issn | 2666-061X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Arthroscopy, Sports Medicine, and Rehabilitation |
| spelling | doaj-art-4e1bf28787f74c8b9cd23e06ab78dcdf2025-08-20T02:34:20ZengElsevierArthroscopy, Sports Medicine, and Rehabilitation2666-061X2024-12-016610099210.1016/j.asmr.2024.100992Cumulative Impact Loading and Cartilage Synthesis Biomarkers May Be Associated With Injury Risk in Female Collegiate Basketball PlayersJulie P. Burland, Ph.D., A.T.C., C.S.C.S.0Michael Szymanski, Ph.D., A.T.C.1Jeb Struder, Ph.D.2Margaret Morrissey, Ph.D.3Michelle Van Dyke, Ph.D.4Christian Lattermann, M.D.5Janelle Francisco, M.S., A.T.C.6Cory M. Edgar, M.D., Ph.D.7Department of Kinesiology, University of Connecticut, Storrs, Connecticut, U.S.A.; UConn Institute for Sports Medicine, University of Connecticut, Storrs, Connecticut, U.S.A.; Address correspondence to Julie P. Burland, Ph.D., A.T.C., C.S.C.S., Department of Kinesiology, UConn Institute for Sports Medicine, University of Connecticut, 2095 Hillside Rd., U-1110, Storrs, Connecticut 06269, U.S.A.Department of Kinesiology, University of Connecticut, Storrs, Connecticut, U.S.A.University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, U.S.A.Providence College, Providence, Rhode Island, U.S.A.Department of Athletics, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A.Brigham and Women’s Hospital, Foxborough, Massachusetts, U.S.A.UConn Athletics, University of Connecticut, Storrs, Connecticut, U.S.A.UConn Institute for Sports Medicine, University of Connecticut, Storrs, Connecticut, U.S.A.; University of Connecticut Health Center, Farmington, Connecticut, U.S.A.Purpose: To evaluate whether cumulative impact load and serum biomarkers are related to lower-extremity injury and to determine any impact load and cartilage biomarker relationships in collegiate female basketball athletes. Methods: This was a prospective longitudinal study evaluating lower-extremity impact load, serum cartilage biomarkers, and injury incidence over the course of a single collegiate women’s basketball season. Data were collected from August 2022 to April 2023; no other follow-up after the cessation of the season was conducted in this cohort. Inclusion criteria for the study included collegiate women’s basketball athletes, ages 18 to 25 years, who were noninjured at the start of the study time frame (August 2024). Cartilage synthesis (procollagen II carboxy propeptide and aggrecan chondroitin sulfate 846 epitope) and degradation (collagen type II cleavage) biomarkers were evaluated at 6 season timepoints. Impact load metrics (cumulative bone stimulus, impact intensity) were collected during practices using inertial measurement units secured to the distal medial tibiae. Injury was defined as restriction of participation for 1 or more days beyond day of initial injury. Cumulative impact load metrics were calculated over the week before any documented injury and blood draws for analysis. Point biserial and Pearson product moment correlations were used to determine the relationship between impact load metrics, serum biomarkers, and injury. Results: Eleven collegiate women’s basketball athletes (height: 1.86 meters, mass: 82.0 kg, age: 20.54 years) participated. Greater medium-range (6-20 g) cumulative impact intensities during week 5 and 6 for both limbs (r = 0.674, P = .023) and high-range (20-200 g) during week 8 for both limbs (0.672, P = .024) were associated with injury. Greater cumulative bone stimulus was associated with increased procollagen II carboxy propeptide levels before conference playoffs for right (r = 0.694, P = .026) and left (r = 0.747, P = .013) limbs. Greater chondroitin sulfate 846 epitope levels at off-season-1 (r = 0.729, P = .017), and at the beginning of the competitive season (r = 0.645, P = .044) were associated with season-long injury incidence. Conclusions: In this study, we found that moderate-to-high intensity impacts (6-200 g) early in the season were associated with subsequent injury among female collegiate basketball players. Increased cartilage synthesis at various time points was correlated with increased cumulative bone stimulus metrics and season-long injury incidence in this population. Level of Evidence: Level IV, prognostic case series.http://www.sciencedirect.com/science/article/pii/S2666061X24001299 |
| spellingShingle | Julie P. Burland, Ph.D., A.T.C., C.S.C.S. Michael Szymanski, Ph.D., A.T.C. Jeb Struder, Ph.D. Margaret Morrissey, Ph.D. Michelle Van Dyke, Ph.D. Christian Lattermann, M.D. Janelle Francisco, M.S., A.T.C. Cory M. Edgar, M.D., Ph.D. Cumulative Impact Loading and Cartilage Synthesis Biomarkers May Be Associated With Injury Risk in Female Collegiate Basketball Players Arthroscopy, Sports Medicine, and Rehabilitation |
| title | Cumulative Impact Loading and Cartilage Synthesis Biomarkers May Be Associated With Injury Risk in Female Collegiate Basketball Players |
| title_full | Cumulative Impact Loading and Cartilage Synthesis Biomarkers May Be Associated With Injury Risk in Female Collegiate Basketball Players |
| title_fullStr | Cumulative Impact Loading and Cartilage Synthesis Biomarkers May Be Associated With Injury Risk in Female Collegiate Basketball Players |
| title_full_unstemmed | Cumulative Impact Loading and Cartilage Synthesis Biomarkers May Be Associated With Injury Risk in Female Collegiate Basketball Players |
| title_short | Cumulative Impact Loading and Cartilage Synthesis Biomarkers May Be Associated With Injury Risk in Female Collegiate Basketball Players |
| title_sort | cumulative impact loading and cartilage synthesis biomarkers may be associated with injury risk in female collegiate basketball players |
| url | http://www.sciencedirect.com/science/article/pii/S2666061X24001299 |
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