Metabolic engineering approaches for the biosynthesis of antibiotics
Abstract Background Antibiotics have been saving countless lives from deadly infectious diseases, which we now often take for granted. However, we are currently witnessing a significant rise in the emergence of multidrug-resistant (MDR) bacteria, making these infections increasingly difficult to tre...
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| Format: | Article |
| Language: | English |
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BMC
2025-01-01
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| Series: | Microbial Cell Factories |
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| Online Access: | https://doi.org/10.1186/s12934-024-02628-2 |
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| author | Geunsoo Yook Jiwoo Nam Yeonseo Jo Hyunji Yoon Dongsoo Yang |
| author_facet | Geunsoo Yook Jiwoo Nam Yeonseo Jo Hyunji Yoon Dongsoo Yang |
| author_sort | Geunsoo Yook |
| collection | DOAJ |
| description | Abstract Background Antibiotics have been saving countless lives from deadly infectious diseases, which we now often take for granted. However, we are currently witnessing a significant rise in the emergence of multidrug-resistant (MDR) bacteria, making these infections increasingly difficult to treat in hospitals. Main text The discovery and development of new antibiotic has slowed, largely due to reduced profitability, as antibiotics often lose effectiveness quickly as pathogenic bacteria evolve into MDR strains. To address this challenge, metabolic engineering has recently become crucial in developing efficient enzymes and cell factories capable of producing both existing antibiotics and a wide range of new derivatives and analogs. In this paper, we review recent tools and strategies in metabolic engineering and synthetic biology for antibiotic discovery and the efficient production of antibiotics, their derivatives, and analogs, along with representative examples. Conclusion These metabolic engineering and synthetic biology strategies offer promising potential to revitalize the discovery and development of new antibiotics, providing renewed hope in humanity’s fight against MDR pathogenic bacteria. |
| format | Article |
| id | doaj-art-4e041b3513834551b12aae627f31691c |
| institution | Kabale University |
| issn | 1475-2859 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Microbial Cell Factories |
| spelling | doaj-art-4e041b3513834551b12aae627f31691c2025-02-02T12:48:36ZengBMCMicrobial Cell Factories1475-28592025-01-0124114110.1186/s12934-024-02628-2Metabolic engineering approaches for the biosynthesis of antibioticsGeunsoo Yook0Jiwoo Nam1Yeonseo Jo2Hyunji Yoon3Dongsoo Yang4Synthetic Biology and Enzyme Engineering Laboratory, Department of Chemical and Biological Engineering, Korea UniversitySynthetic Biology and Enzyme Engineering Laboratory, Department of Chemical and Biological Engineering, Korea UniversitySynthetic Biology and Enzyme Engineering Laboratory, Department of Chemical and Biological Engineering, Korea UniversitySynthetic Biology and Enzyme Engineering Laboratory, Department of Chemical and Biological Engineering, Korea UniversitySynthetic Biology and Enzyme Engineering Laboratory, Department of Chemical and Biological Engineering, Korea UniversityAbstract Background Antibiotics have been saving countless lives from deadly infectious diseases, which we now often take for granted. However, we are currently witnessing a significant rise in the emergence of multidrug-resistant (MDR) bacteria, making these infections increasingly difficult to treat in hospitals. Main text The discovery and development of new antibiotic has slowed, largely due to reduced profitability, as antibiotics often lose effectiveness quickly as pathogenic bacteria evolve into MDR strains. To address this challenge, metabolic engineering has recently become crucial in developing efficient enzymes and cell factories capable of producing both existing antibiotics and a wide range of new derivatives and analogs. In this paper, we review recent tools and strategies in metabolic engineering and synthetic biology for antibiotic discovery and the efficient production of antibiotics, their derivatives, and analogs, along with representative examples. Conclusion These metabolic engineering and synthetic biology strategies offer promising potential to revitalize the discovery and development of new antibiotics, providing renewed hope in humanity’s fight against MDR pathogenic bacteria.https://doi.org/10.1186/s12934-024-02628-2AntibioticsSynthetic biologyMetabolic engineeringActinomycetesBiosynthetic gene cluster |
| spellingShingle | Geunsoo Yook Jiwoo Nam Yeonseo Jo Hyunji Yoon Dongsoo Yang Metabolic engineering approaches for the biosynthesis of antibiotics Microbial Cell Factories Antibiotics Synthetic biology Metabolic engineering Actinomycetes Biosynthetic gene cluster |
| title | Metabolic engineering approaches for the biosynthesis of antibiotics |
| title_full | Metabolic engineering approaches for the biosynthesis of antibiotics |
| title_fullStr | Metabolic engineering approaches for the biosynthesis of antibiotics |
| title_full_unstemmed | Metabolic engineering approaches for the biosynthesis of antibiotics |
| title_short | Metabolic engineering approaches for the biosynthesis of antibiotics |
| title_sort | metabolic engineering approaches for the biosynthesis of antibiotics |
| topic | Antibiotics Synthetic biology Metabolic engineering Actinomycetes Biosynthetic gene cluster |
| url | https://doi.org/10.1186/s12934-024-02628-2 |
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