An injectable multifunctional nanocomposite hydrogel promotes vascularized bone regeneration by regulating macrophages

An injectable multifunctional nanocomposite hydrogel promotes vascularized bone regeneration by regulating macrophages

Abstract The local inflammatory microenvironment, insufficient vascularization, and inadequate bone repair materials are the three key factors that constrain the repair of bone defects. Here, we synthesized a composite nanoparticle, TPQ (TCP-PDA-QK), with a core‒shell structure. The core consists of...

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Bibliographic Details
Main Authors: Huaiyuan Zhang, Yu Wang, Wenyu Qiao, Xueneng Hu, Huifen Qiang, Kuo Xia, Longhai Du, Luling Yang, Yi Bao, Jie Gao, Tinglin Zhang, Zuochong Yu
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Journal of Nanobiotechnology
Subjects:
Inflammatory microenvironment
Bone defects
Core‒shell structure
M2 macrophage polarization
Vascularization
Bone regeneration
Online Access:https://doi.org/10.1186/s12951-025-03358-2
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