Desmopressin prescription safety in adult inpatients: a real-world tertiary centre experience
Omissions or delays in desmopressin can result in serious patient harm in patients with arginine vasopressin deficiency (AVP-D), formally known as cranial diabetes insipidus. Desmopressin administration practice in hospitals has not been thoroughly investigated previously. This study evaluated desmo...
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Bioscientifica
2025-02-01
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| Series: | Endocrine Connections |
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| Online Access: | https://ec.bioscientifica.com/view/journals/ec/14/3/EC-24-0441.xml |
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| author | Muhammad Fahad Arshad Sam Solanki Luka Dancyger-Stevens Madushani Karunanayaka Ee-Wen Loh Kyaw Naing Htoon Mohanad Turki Alia Munir |
| author_facet | Muhammad Fahad Arshad Sam Solanki Luka Dancyger-Stevens Madushani Karunanayaka Ee-Wen Loh Kyaw Naing Htoon Mohanad Turki Alia Munir |
| author_sort | Muhammad Fahad Arshad |
| collection | DOAJ |
| description | Omissions or delays in desmopressin can result in serious patient harm in patients with arginine vasopressin deficiency (AVP-D), formally known as cranial diabetes insipidus. Desmopressin administration practice in hospitals has not been thoroughly investigated previously. This study evaluated desmopressin prescription and administration practice at a large tertiary centre. A retrospective electronic case notes review of all admissions (≥24 h) with AVP-D between 2018 and 2021 at Sheffield Teaching Hospitals was undertaken. The outcomes were defined as the total number of missed and delayed doses, time to prescription and administration from admission and incidence of dysnatraemias. A qualitative survey to determine knowledge of AVP-D and desmopressin among staff members was also carried out. In total, 102 admissions were identified, of which 38% of admissions were via emergency department (ED). The total number of missed and delayed doses were 132/1315 (10.0%) and 139/1283 (10.9%), respectively. Of all admissions, 33% had ≥1 missed doses, while ≥1 doses were delayed in 54% admissions. ED rates of desmopressin prescription were low at 5%. The most common reasons documented for missed or delayed doses were unavailability of desmopressin followed by inability of the patient to take the medication. Median (interquartile range) prescription and administration times from admission were 5.6 (2.7–10.7) and 15.1 (8.7–27.0) h, respectively. The incidence of inpatient hypernatraemia and hyponatraemia was 7.6 and 30.4%, respectively. The staff survey showed below-average knowledge of the condition, advocating for an urgent need for education. |
| format | Article |
| id | doaj-art-4dff294e1df94cc7b7fc64e2bbdd3ea5 |
| institution | DOAJ |
| issn | 2049-3614 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj-art-4dff294e1df94cc7b7fc64e2bbdd3ea52025-08-20T03:12:40ZengBioscientificaEndocrine Connections2049-36142025-02-0114310.1530/EC-24-04411Desmopressin prescription safety in adult inpatients: a real-world tertiary centre experienceMuhammad Fahad Arshad0Sam Solanki1Luka Dancyger-Stevens2Madushani Karunanayaka3Ee-Wen Loh4Kyaw Naing Htoon5Mohanad Turki6Alia Munir7University of Sheffield, Sheffield, UKUniversity of Sheffield, Sheffield, UKUniversity of Sheffield, Sheffield, UKSheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UKSheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UKSheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UKUniversity of Sheffield, Sheffield, UKSheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UKOmissions or delays in desmopressin can result in serious patient harm in patients with arginine vasopressin deficiency (AVP-D), formally known as cranial diabetes insipidus. Desmopressin administration practice in hospitals has not been thoroughly investigated previously. This study evaluated desmopressin prescription and administration practice at a large tertiary centre. A retrospective electronic case notes review of all admissions (≥24 h) with AVP-D between 2018 and 2021 at Sheffield Teaching Hospitals was undertaken. The outcomes were defined as the total number of missed and delayed doses, time to prescription and administration from admission and incidence of dysnatraemias. A qualitative survey to determine knowledge of AVP-D and desmopressin among staff members was also carried out. In total, 102 admissions were identified, of which 38% of admissions were via emergency department (ED). The total number of missed and delayed doses were 132/1315 (10.0%) and 139/1283 (10.9%), respectively. Of all admissions, 33% had ≥1 missed doses, while ≥1 doses were delayed in 54% admissions. ED rates of desmopressin prescription were low at 5%. The most common reasons documented for missed or delayed doses were unavailability of desmopressin followed by inability of the patient to take the medication. Median (interquartile range) prescription and administration times from admission were 5.6 (2.7–10.7) and 15.1 (8.7–27.0) h, respectively. The incidence of inpatient hypernatraemia and hyponatraemia was 7.6 and 30.4%, respectively. The staff survey showed below-average knowledge of the condition, advocating for an urgent need for education.https://ec.bioscientifica.com/view/journals/ec/14/3/EC-24-0441.xmlarginine vasopressin deficiencycranial diabetes insipidusdesmopressinpatient safety |
| spellingShingle | Muhammad Fahad Arshad Sam Solanki Luka Dancyger-Stevens Madushani Karunanayaka Ee-Wen Loh Kyaw Naing Htoon Mohanad Turki Alia Munir Desmopressin prescription safety in adult inpatients: a real-world tertiary centre experience Endocrine Connections arginine vasopressin deficiency cranial diabetes insipidus desmopressin patient safety |
| title | Desmopressin prescription safety in adult inpatients: a real-world tertiary centre experience |
| title_full | Desmopressin prescription safety in adult inpatients: a real-world tertiary centre experience |
| title_fullStr | Desmopressin prescription safety in adult inpatients: a real-world tertiary centre experience |
| title_full_unstemmed | Desmopressin prescription safety in adult inpatients: a real-world tertiary centre experience |
| title_short | Desmopressin prescription safety in adult inpatients: a real-world tertiary centre experience |
| title_sort | desmopressin prescription safety in adult inpatients a real world tertiary centre experience |
| topic | arginine vasopressin deficiency cranial diabetes insipidus desmopressin patient safety |
| url | https://ec.bioscientifica.com/view/journals/ec/14/3/EC-24-0441.xml |
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