NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C
The study is aimed at assessing the impact that periodontal disease and chronic hepatitis C could have on gingival crevicular fluid levels of the NLRP3 inflammasome, caspase-1 (CASP-1), and interleukin-18 (IL-18) and at evaluating whether the increased local inflammatory reaction with clinical perio...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/6917919 |
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| author | Petra Surlin Luminita Lazar Cerasella Sincar Dorin Nicolae Gheorghe Dora Maria Popescu Virgil Mihail Boldeanu Allma Pitru Cristina Florescu Ion Rogoveanu |
| author_facet | Petra Surlin Luminita Lazar Cerasella Sincar Dorin Nicolae Gheorghe Dora Maria Popescu Virgil Mihail Boldeanu Allma Pitru Cristina Florescu Ion Rogoveanu |
| author_sort | Petra Surlin |
| collection | DOAJ |
| description | The study is aimed at assessing the impact that periodontal disease and chronic hepatitis C could have on gingival crevicular fluid levels of the NLRP3 inflammasome, caspase-1 (CASP-1), and interleukin-18 (IL-18) and at evaluating whether the increased local inflammatory reaction with clinical periodontal consequences is correlated to their upregulation. Patients were divided into four groups, according to their periodontal status and previously diagnosed hepatitis C, as follows: (i) CHC group, chronic hepatitis C patients; (ii) P group, periodontal disease patients, systemically healthy; (iii) CHC + P group, patients suffering from both conditions; and (iv) H group, systemically and periodontally healthy controls. Gingival crevicular samples were collected for quantitative analysis of the NLRP3 inflammasome, CASP-1, and IL-18. CHC + P patients expressed the worse periodontal status and the highest NLRP3, CASP-1, and IL-18 levels, the difference being statistically significant (p<0.05). The P group patients also expressed significantly more elevated NLRP3, CASP-1, and IL-18 levels, as compared to nonperiodontal patients (CHC and H groups). Chronic hepatitis C and periodontal disease could have a significant influence on the upregulation of NLRP3 inflammasome and its components, possibly contributing to an increased local inflammatory reaction and clinical periodontal consequences. |
| format | Article |
| id | doaj-art-4df7184ea2db4fe7a226bbbb0784db99 |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-4df7184ea2db4fe7a226bbbb0784db992025-02-03T05:57:19ZengWileyMediators of Inflammation1466-18612021-01-01202110.1155/2021/6917919NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis CPetra Surlin0Luminita Lazar1Cerasella Sincar2Dorin Nicolae Gheorghe3Dora Maria Popescu4Virgil Mihail Boldeanu5Allma Pitru6Cristina Florescu7Ion Rogoveanu8Department of PeriodontologyDepartment of PeriodontologyDepartment of PeriodontologyDepartment of PeriodontologyDepartment of PeriodontologyDepartment of ImmunologyDepartment of Oral PathologyDepartment of Internal Medicine and CardiologyDepartment of GastroenterologyThe study is aimed at assessing the impact that periodontal disease and chronic hepatitis C could have on gingival crevicular fluid levels of the NLRP3 inflammasome, caspase-1 (CASP-1), and interleukin-18 (IL-18) and at evaluating whether the increased local inflammatory reaction with clinical periodontal consequences is correlated to their upregulation. Patients were divided into four groups, according to their periodontal status and previously diagnosed hepatitis C, as follows: (i) CHC group, chronic hepatitis C patients; (ii) P group, periodontal disease patients, systemically healthy; (iii) CHC + P group, patients suffering from both conditions; and (iv) H group, systemically and periodontally healthy controls. Gingival crevicular samples were collected for quantitative analysis of the NLRP3 inflammasome, CASP-1, and IL-18. CHC + P patients expressed the worse periodontal status and the highest NLRP3, CASP-1, and IL-18 levels, the difference being statistically significant (p<0.05). The P group patients also expressed significantly more elevated NLRP3, CASP-1, and IL-18 levels, as compared to nonperiodontal patients (CHC and H groups). Chronic hepatitis C and periodontal disease could have a significant influence on the upregulation of NLRP3 inflammasome and its components, possibly contributing to an increased local inflammatory reaction and clinical periodontal consequences.http://dx.doi.org/10.1155/2021/6917919 |
| spellingShingle | Petra Surlin Luminita Lazar Cerasella Sincar Dorin Nicolae Gheorghe Dora Maria Popescu Virgil Mihail Boldeanu Allma Pitru Cristina Florescu Ion Rogoveanu NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C Mediators of Inflammation |
| title | NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C |
| title_full | NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C |
| title_fullStr | NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C |
| title_full_unstemmed | NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C |
| title_short | NLRP3 Inflammasome Expression in Gingival Crevicular Fluid of Patients with Periodontitis and Chronic Hepatitis C |
| title_sort | nlrp3 inflammasome expression in gingival crevicular fluid of patients with periodontitis and chronic hepatitis c |
| url | http://dx.doi.org/10.1155/2021/6917919 |
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