Clinical and novel insights into risk factors for sarcopenia in dialysis patients: a systematic review and meta-analysis
Abstract Objective We employed a meta-analysis to investigate the risk factors associated with sarcopenia in patients undergoing dialysis. Methods We conducted a search in PubMed, Embase, Cochrane Library, and Web of Science databases. Inclusion criteria included case–control and cohort studies on r...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | BMC Musculoskeletal Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12891-025-08317-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832595042657632256 |
|---|---|
| author | Yifei Zhang Zeyu Zhang Zijing Cao Xuehui Bai Shujiao Zhang Shuaixing Zhang Jingyi Tang Junyu Xi Yiran Xie Yuqi Wu Zhongjie Liu Weijing Liu |
| author_facet | Yifei Zhang Zeyu Zhang Zijing Cao Xuehui Bai Shujiao Zhang Shuaixing Zhang Jingyi Tang Junyu Xi Yiran Xie Yuqi Wu Zhongjie Liu Weijing Liu |
| author_sort | Yifei Zhang |
| collection | DOAJ |
| description | Abstract Objective We employed a meta-analysis to investigate the risk factors associated with sarcopenia in patients undergoing dialysis. Methods We conducted a search in PubMed, Embase, Cochrane Library, and Web of Science databases. Inclusion criteria included case–control and cohort studies on risk factors for sarcopenia in dialysis patients. The search period spanned from the inception of each database to September 20, 2024. The quality of the included studies was assessed using the Newcastle–Ottawa Scale (NOS). Data analysis was performed using Stata 15.0. Result A total of 625 articles were screened, with 610 articles excluded based on predefined eligibility criteria, resulting in 15 articles involving 2904 individuals were included in the final analysis, meta-analysis results indicate that older dialysis patients [SMD = 0.76, 95% CI (0.54, 0.99), I2 = 81%, P = 0.001], those with a lower BMI [SMD = -0.50, 95% CI (-0.80, -0.20), I2% = 87.4%, P = 0.02], a lower SMI [SMD = -2.67, 95% CI (-3.87, -1.47), I2% = 98.2%, P = 0.001], and those with diabetes [OR = 1.43, 95% CI (1.13, 1.82), I2% = 48.8%, P = 0.03] are more likely to develop sarcopenia. Conclusion Based on current research, our study found that elderly dialysis patients, those with a lower BMI, lower SMI, and diabetic patients are more likely to develop sarcopenia. These findings highlight the necessity of early intervention for these high-risk groups. However, the study has limitations. Future research should address these limitations and investigate the mechanisms linking these risk factors to sarcopenia to develop targeted prevention and treatment strategies. |
| format | Article |
| id | doaj-art-4df639c61a714030b3f30d5964fc95f4 |
| institution | Kabale University |
| issn | 1471-2474 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj-art-4df639c61a714030b3f30d5964fc95f42025-01-19T12:04:36ZengBMCBMC Musculoskeletal Disorders1471-24742025-01-0126111110.1186/s12891-025-08317-4Clinical and novel insights into risk factors for sarcopenia in dialysis patients: a systematic review and meta-analysisYifei Zhang0Zeyu Zhang1Zijing Cao2Xuehui Bai3Shujiao Zhang4Shuaixing Zhang5Jingyi Tang6Junyu Xi7Yiran Xie8Yuqi Wu9Zhongjie Liu10Weijing Liu11Dongzhimen Hospital, Beijing University of Chinese MedicineDongzhimen Hospital, Beijing University of Chinese MedicineBeijing Puren HospitalDongzhimen Hospital, Beijing University of Chinese MedicineDongzhimen Hospital, Beijing University of Chinese MedicineDongzhimen Hospital, Beijing University of Chinese MedicineDongzhimen Hospital, Beijing University of Chinese MedicineDongzhimen Hospital, Beijing University of Chinese MedicineDongzhimen Hospital, Beijing University of Chinese MedicineDongzhimen Hospital, Beijing University of Chinese MedicineDongzhimen Hospital, Beijing University of Chinese MedicineDongzhimen Hospital, Beijing University of Chinese MedicineAbstract Objective We employed a meta-analysis to investigate the risk factors associated with sarcopenia in patients undergoing dialysis. Methods We conducted a search in PubMed, Embase, Cochrane Library, and Web of Science databases. Inclusion criteria included case–control and cohort studies on risk factors for sarcopenia in dialysis patients. The search period spanned from the inception of each database to September 20, 2024. The quality of the included studies was assessed using the Newcastle–Ottawa Scale (NOS). Data analysis was performed using Stata 15.0. Result A total of 625 articles were screened, with 610 articles excluded based on predefined eligibility criteria, resulting in 15 articles involving 2904 individuals were included in the final analysis, meta-analysis results indicate that older dialysis patients [SMD = 0.76, 95% CI (0.54, 0.99), I2 = 81%, P = 0.001], those with a lower BMI [SMD = -0.50, 95% CI (-0.80, -0.20), I2% = 87.4%, P = 0.02], a lower SMI [SMD = -2.67, 95% CI (-3.87, -1.47), I2% = 98.2%, P = 0.001], and those with diabetes [OR = 1.43, 95% CI (1.13, 1.82), I2% = 48.8%, P = 0.03] are more likely to develop sarcopenia. Conclusion Based on current research, our study found that elderly dialysis patients, those with a lower BMI, lower SMI, and diabetic patients are more likely to develop sarcopenia. These findings highlight the necessity of early intervention for these high-risk groups. However, the study has limitations. Future research should address these limitations and investigate the mechanisms linking these risk factors to sarcopenia to develop targeted prevention and treatment strategies.https://doi.org/10.1186/s12891-025-08317-4Risk factorsSarcopeniaDialysisMeta-analysis |
| spellingShingle | Yifei Zhang Zeyu Zhang Zijing Cao Xuehui Bai Shujiao Zhang Shuaixing Zhang Jingyi Tang Junyu Xi Yiran Xie Yuqi Wu Zhongjie Liu Weijing Liu Clinical and novel insights into risk factors for sarcopenia in dialysis patients: a systematic review and meta-analysis BMC Musculoskeletal Disorders Risk factors Sarcopenia Dialysis Meta-analysis |
| title | Clinical and novel insights into risk factors for sarcopenia in dialysis patients: a systematic review and meta-analysis |
| title_full | Clinical and novel insights into risk factors for sarcopenia in dialysis patients: a systematic review and meta-analysis |
| title_fullStr | Clinical and novel insights into risk factors for sarcopenia in dialysis patients: a systematic review and meta-analysis |
| title_full_unstemmed | Clinical and novel insights into risk factors for sarcopenia in dialysis patients: a systematic review and meta-analysis |
| title_short | Clinical and novel insights into risk factors for sarcopenia in dialysis patients: a systematic review and meta-analysis |
| title_sort | clinical and novel insights into risk factors for sarcopenia in dialysis patients a systematic review and meta analysis |
| topic | Risk factors Sarcopenia Dialysis Meta-analysis |
| url | https://doi.org/10.1186/s12891-025-08317-4 |
| work_keys_str_mv | AT yifeizhang clinicalandnovelinsightsintoriskfactorsforsarcopeniaindialysispatientsasystematicreviewandmetaanalysis AT zeyuzhang clinicalandnovelinsightsintoriskfactorsforsarcopeniaindialysispatientsasystematicreviewandmetaanalysis AT zijingcao clinicalandnovelinsightsintoriskfactorsforsarcopeniaindialysispatientsasystematicreviewandmetaanalysis AT xuehuibai clinicalandnovelinsightsintoriskfactorsforsarcopeniaindialysispatientsasystematicreviewandmetaanalysis AT shujiaozhang clinicalandnovelinsightsintoriskfactorsforsarcopeniaindialysispatientsasystematicreviewandmetaanalysis AT shuaixingzhang clinicalandnovelinsightsintoriskfactorsforsarcopeniaindialysispatientsasystematicreviewandmetaanalysis AT jingyitang clinicalandnovelinsightsintoriskfactorsforsarcopeniaindialysispatientsasystematicreviewandmetaanalysis AT junyuxi clinicalandnovelinsightsintoriskfactorsforsarcopeniaindialysispatientsasystematicreviewandmetaanalysis AT yiranxie clinicalandnovelinsightsintoriskfactorsforsarcopeniaindialysispatientsasystematicreviewandmetaanalysis AT yuqiwu clinicalandnovelinsightsintoriskfactorsforsarcopeniaindialysispatientsasystematicreviewandmetaanalysis AT zhongjieliu clinicalandnovelinsightsintoriskfactorsforsarcopeniaindialysispatientsasystematicreviewandmetaanalysis AT weijingliu clinicalandnovelinsightsintoriskfactorsforsarcopeniaindialysispatientsasystematicreviewandmetaanalysis |