The Spectrophotometric Multicomponent Analysis of a Ternary Mixture of Ibuprofen, Caffeine and Paracetamol by the Combination of Double Divisor-Ratio Spectra Derivative and H-Point Standard Addition Method
A new spectrophotometric method was developed for the simultaneous analysis of a ternary mixture containing paracetamol (PAR), ibuprofen (IBU) and caffeine (CAF) without prior separation. H-point standard addition method (HPSAM) was used for the first time in the analysis of a component (IBU) in a t...
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| Format: | Article |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/621263 |
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| author | R. Hajian N. Afshari |
| author_facet | R. Hajian N. Afshari |
| author_sort | R. Hajian |
| collection | DOAJ |
| description | A new spectrophotometric method was developed for the simultaneous analysis of a ternary mixture containing paracetamol (PAR), ibuprofen (IBU) and caffeine (CAF) without prior separation. H-point standard addition method (HPSAM) was used for the first time in the analysis of a component (IBU) in a ternary mixture (paracetamol, ibuprofen and caffeine). In contrast, PAR and CAF determined using double divisor ratio spectra derivative method. This method is based on the use of derivative of the ratio spectrum obtained by dividing the absorption spectrum of the ternary mixture by a standard spectrum of a mixture of two of the three compounds in the title mixture. The concentrations of PAR and CAF compounds in their mixture are determined by using their respective standard addition graphs which are obtained by measuring the amplitude at either the maximum or minimum wavelengths selected. The mathematical explanation of the procedure is illustrated. It was shown that at wavelengths 226 and 260 nm, the coordinate of H-point is only dependent on the concentration of IBU without any interference by PAR and CAF. This method was successfully applied for the analysis of Novafen capsule, with no interference from excipients as indicated by the recovery study results. The proposed method is simple and rapid and can be easily used in the quality control of drugs as an alternative analysis tools. |
| format | Article |
| id | doaj-art-4df1800f2a3f454a9d8b95004dcd575e |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
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| series | E-Journal of Chemistry |
| spelling | doaj-art-4df1800f2a3f454a9d8b95004dcd575e2025-02-03T00:59:55ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-01931153116410.1155/2012/621263The Spectrophotometric Multicomponent Analysis of a Ternary Mixture of Ibuprofen, Caffeine and Paracetamol by the Combination of Double Divisor-Ratio Spectra Derivative and H-Point Standard Addition MethodR. Hajian0N. Afshari1Young Researchers Club, Gachsaran Branch, Islamic Azad University, Gachsaran, IranGachsaran Branch, Islamic Azad University, Gachsaran, IranA new spectrophotometric method was developed for the simultaneous analysis of a ternary mixture containing paracetamol (PAR), ibuprofen (IBU) and caffeine (CAF) without prior separation. H-point standard addition method (HPSAM) was used for the first time in the analysis of a component (IBU) in a ternary mixture (paracetamol, ibuprofen and caffeine). In contrast, PAR and CAF determined using double divisor ratio spectra derivative method. This method is based on the use of derivative of the ratio spectrum obtained by dividing the absorption spectrum of the ternary mixture by a standard spectrum of a mixture of two of the three compounds in the title mixture. The concentrations of PAR and CAF compounds in their mixture are determined by using their respective standard addition graphs which are obtained by measuring the amplitude at either the maximum or minimum wavelengths selected. The mathematical explanation of the procedure is illustrated. It was shown that at wavelengths 226 and 260 nm, the coordinate of H-point is only dependent on the concentration of IBU without any interference by PAR and CAF. This method was successfully applied for the analysis of Novafen capsule, with no interference from excipients as indicated by the recovery study results. The proposed method is simple and rapid and can be easily used in the quality control of drugs as an alternative analysis tools.http://dx.doi.org/10.1155/2012/621263 |
| spellingShingle | R. Hajian N. Afshari The Spectrophotometric Multicomponent Analysis of a Ternary Mixture of Ibuprofen, Caffeine and Paracetamol by the Combination of Double Divisor-Ratio Spectra Derivative and H-Point Standard Addition Method E-Journal of Chemistry |
| title | The Spectrophotometric Multicomponent Analysis of a Ternary Mixture of Ibuprofen, Caffeine and Paracetamol by the Combination of Double Divisor-Ratio Spectra Derivative and H-Point Standard Addition Method |
| title_full | The Spectrophotometric Multicomponent Analysis of a Ternary Mixture of Ibuprofen, Caffeine and Paracetamol by the Combination of Double Divisor-Ratio Spectra Derivative and H-Point Standard Addition Method |
| title_fullStr | The Spectrophotometric Multicomponent Analysis of a Ternary Mixture of Ibuprofen, Caffeine and Paracetamol by the Combination of Double Divisor-Ratio Spectra Derivative and H-Point Standard Addition Method |
| title_full_unstemmed | The Spectrophotometric Multicomponent Analysis of a Ternary Mixture of Ibuprofen, Caffeine and Paracetamol by the Combination of Double Divisor-Ratio Spectra Derivative and H-Point Standard Addition Method |
| title_short | The Spectrophotometric Multicomponent Analysis of a Ternary Mixture of Ibuprofen, Caffeine and Paracetamol by the Combination of Double Divisor-Ratio Spectra Derivative and H-Point Standard Addition Method |
| title_sort | spectrophotometric multicomponent analysis of a ternary mixture of ibuprofen caffeine and paracetamol by the combination of double divisor ratio spectra derivative and h point standard addition method |
| url | http://dx.doi.org/10.1155/2012/621263 |
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