Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population
Inflammatory bowel diseases (IBDs) comprising Crohn disease (CD) and ulcerative colitis (UC) are chronic inflammatory conditions with polygenic susceptibility. Interactions between TNF-alpha and TNF-alpha receptor play a fundamental role in inflammatory response. This study investigates the role tha...
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| Format: | Article |
| Language: | English |
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Wiley
2009-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2009/591704 |
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| author | Lynnette R. Ferguson Dug Yeo Han Claudia Huebner Ivonne Petermann Murray L. Barclay Richard B. Gearry Alan McCulloch Pieter S. Demmers |
| author_facet | Lynnette R. Ferguson Dug Yeo Han Claudia Huebner Ivonne Petermann Murray L. Barclay Richard B. Gearry Alan McCulloch Pieter S. Demmers |
| author_sort | Lynnette R. Ferguson |
| collection | DOAJ |
| description | Inflammatory bowel diseases (IBDs) comprising Crohn disease (CD) and ulcerative colitis (UC) are chronic inflammatory conditions with polygenic susceptibility. Interactions between TNF-alpha and TNF-alpha receptor play a fundamental role in inflammatory response. This study investigates the role that selected single nucleotide polymorphisms (SNPs) and haplotypes in the TNF-alpha receptor (TNSFRSF1B) gene play in the risk of IBD in a New Zealand Caucasian population. DNA samples from 388 CD, 405 UC, 27 indeterminate colitis patients, and 293 randomly selected controls, from Canterbury, New Zealand were screened for 3 common SNPs in TNSFRSF1B: rs1061622 (c.676T>C), rs1061624 (c.∗1663A>G), and rs3397 (c.∗1690T>C), using TaqMan technologies. Carrying the rs1061624 variant decreased the risk of UC in the left colon (OR 0.73, 95% CI=0.54–1.00) and of being a smoker at diagnosis (OR 0.62; 95% CI=0.40–0.96). Carrying the rs3397 variant decreased the risk of penetrating CD (OR 0.62, 95% CI=0.40–0.95). Three marker haplotype analyses revealed highly significant differences between CD patients and control subjects (χ2=29.9, df=7, P=.0001) and UC cases and controls (χ2=46.3, df=7, P<.0001). We conclude that carrying a 3-marker haplotype in the TNSFRSF1B gene may increase (e.g., haplotype of GGC was 2.9-fold more in the CD or UCpatients) or decrease (e.g., TGT was 0.47-fold less in UC patients) the risk of IBD in a New Zealand Caucasian population. |
| format | Article |
| id | doaj-art-4defd19b15824339a91e7eb50be54e35 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2009-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-4defd19b15824339a91e7eb50be54e352025-02-03T05:52:04ZengWileyGastroenterology Research and Practice1687-61211687-630X2009-01-01200910.1155/2009/591704591704Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian PopulationLynnette R. Ferguson0Dug Yeo Han1Claudia Huebner2Ivonne Petermann3Murray L. Barclay4Richard B. Gearry5Alan McCulloch6Pieter S. Demmers7Discipline of Nutrition, The University of Auckland, Private Bag 92019, Auckland 1023, New ZealandDiscipline of Nutrition, The University of Auckland, Private Bag 92019, Auckland 1023, New ZealandDiscipline of Nutrition, The University of Auckland, Private Bag 92019, Auckland 1023, New ZealandDiscipline of Nutrition, The University of Auckland, Private Bag 92019, Auckland 1023, New ZealandDepartment of Gastroenterology, Christchurch Hospital, Christchurch 8011, New ZealandDepartment of Gastroenterology, Christchurch Hospital, Christchurch 8011, New ZealandNutrigenomics New Zealand, New ZealandNutrigenomics New Zealand, New ZealandInflammatory bowel diseases (IBDs) comprising Crohn disease (CD) and ulcerative colitis (UC) are chronic inflammatory conditions with polygenic susceptibility. Interactions between TNF-alpha and TNF-alpha receptor play a fundamental role in inflammatory response. This study investigates the role that selected single nucleotide polymorphisms (SNPs) and haplotypes in the TNF-alpha receptor (TNSFRSF1B) gene play in the risk of IBD in a New Zealand Caucasian population. DNA samples from 388 CD, 405 UC, 27 indeterminate colitis patients, and 293 randomly selected controls, from Canterbury, New Zealand were screened for 3 common SNPs in TNSFRSF1B: rs1061622 (c.676T>C), rs1061624 (c.∗1663A>G), and rs3397 (c.∗1690T>C), using TaqMan technologies. Carrying the rs1061624 variant decreased the risk of UC in the left colon (OR 0.73, 95% CI=0.54–1.00) and of being a smoker at diagnosis (OR 0.62; 95% CI=0.40–0.96). Carrying the rs3397 variant decreased the risk of penetrating CD (OR 0.62, 95% CI=0.40–0.95). Three marker haplotype analyses revealed highly significant differences between CD patients and control subjects (χ2=29.9, df=7, P=.0001) and UC cases and controls (χ2=46.3, df=7, P<.0001). We conclude that carrying a 3-marker haplotype in the TNSFRSF1B gene may increase (e.g., haplotype of GGC was 2.9-fold more in the CD or UCpatients) or decrease (e.g., TGT was 0.47-fold less in UC patients) the risk of IBD in a New Zealand Caucasian population.http://dx.doi.org/10.1155/2009/591704 |
| spellingShingle | Lynnette R. Ferguson Dug Yeo Han Claudia Huebner Ivonne Petermann Murray L. Barclay Richard B. Gearry Alan McCulloch Pieter S. Demmers Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population Gastroenterology Research and Practice |
| title | Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population |
| title_full | Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population |
| title_fullStr | Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population |
| title_full_unstemmed | Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population |
| title_short | Tumor Necrosis Factor Receptor Superfamily, Member 1B Haplotypes Increase or Decrease the Risk of Inflammatory Bowel Diseases in a New Zealand Caucasian Population |
| title_sort | tumor necrosis factor receptor superfamily member 1b haplotypes increase or decrease the risk of inflammatory bowel diseases in a new zealand caucasian population |
| url | http://dx.doi.org/10.1155/2009/591704 |
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