Diagnostic impact of DNA methylation classification in adult and pediatric CNS tumors

Diagnostic impact of DNA methylation classification in adult and pediatric CNS tumors

Abstract Over the past decade, neuropathological diagnosis has undergone significant changes, integrating morphological features with molecular biomarkers. The molecular era has successfully refined neuropathological diagnostic accuracy; however, a substantial number of CNS tumor diagnoses remain ch...

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Main Authors: Laetitia Lebrun, Nathalie Gilis, Manon Dausort, Chloé Gillard, Stefan Rusu, Karim Slimani, Olivier De Witte, Fabienne Escande, Florence Lefranc, Nicky D’Haene, Claude Alain Maurage, Isabelle Salmon
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
DNA methylation
Neuropathology
CNS tumor
Pediatric CNS tumors
Next generation sequencing
DKFZ classifier
Online Access:https://doi.org/10.1038/s41598-025-87079-4
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