Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population
The incidence of gastric cardia cancer (GCC) is high in China. However, the clinicopathological characteristics and the carcinogenesis of GCC are unclear. Toll-like receptor 4 (TLR4) is an important innate immunity receptor and has a role in non-GCC (NGCC). We compared the clinicopathological charac...
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2018/7132868 |
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| author | Guangcan Chen Muming Xu Jingyao Chen Liangli Hong Wenting Lin Shukun Zhao Guohong Zhang Guo Dan Shuhui Liu |
| author_facet | Guangcan Chen Muming Xu Jingyao Chen Liangli Hong Wenting Lin Shukun Zhao Guohong Zhang Guo Dan Shuhui Liu |
| author_sort | Guangcan Chen |
| collection | DOAJ |
| description | The incidence of gastric cardia cancer (GCC) is high in China. However, the clinicopathological characteristics and the carcinogenesis of GCC are unclear. Toll-like receptor 4 (TLR4) is an important innate immunity receptor and has a role in non-GCC (NGCC). We compared the clinicopathological characteristics of GCC patients from a high-risk area in China to esophageal cancer (EC) patients. Immunohistochemistry for TLR4 was performed in 201 histological samples of normal gastric cardia mucosa (n=11), gastric cardia inflammation (n=87), and GCC (n=103). We included 84 patients with EC and 99 with GCC. GCC tissue was more poorly differentiated than EC tissue and more invasive, with more histomorphologic variation. Lymph node metastasis was more frequent in GCC than in EC. The Helicobacter pylori infection rate was higher but not significantly with GCC than EC. Survival was shorter with lymph node metastasis. We found a statistically significant trend for progressive increase of TLR4 expression from normal mucosa to inflammation in GCC. GCC in this high-risk area displays clinicopathologic characteristics different from those of EC and different from those of gastroesophageal junction carcinomas in other countries, although this was not analyzed statistically. Increased TLR4 expression in gastric cardia lesions may be associated with GCC tumorigenesis. |
| format | Article |
| id | doaj-art-4dd36bb89e854eee8e7372055715a622 |
| institution | Kabale University |
| issn | 2314-8861 2314-7156 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-4dd36bb89e854eee8e7372055715a6222025-02-03T05:52:33ZengWileyJournal of Immunology Research2314-88612314-71562018-01-01201810.1155/2018/71328687132868Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese PopulationGuangcan Chen0Muming Xu1Jingyao Chen2Liangli Hong3Wenting Lin4Shukun Zhao5Guohong Zhang6Guo Dan7Shuhui Liu8Department of Gastrointestinal Surgery, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province 515041, ChinaDepartment of Abdominal Surgery, The Tumor Hospital of Shantou University Medical College, Shantou, Guangdong Province 515041, ChinaDepartment of Pathology, Shantou University Medical College, Shantou, Guangdong Province 515031, ChinaDepartment of Pathology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong Province 515041, ChinaDepartment of Pathology, Shantou University Medical College, Shantou, Guangdong Province 515031, ChinaDepartment of Pathology, Shantou University Medical College, Shantou, Guangdong Province 515031, ChinaDepartment of Pathology, Shantou University Medical College, Shantou, Guangdong Province 515031, ChinaDepartment of Pathology, Shantou University Medical College, Shantou, Guangdong Province 515031, ChinaDepartment of Pathology, Shantou University Medical College, Shantou, Guangdong Province 515031, ChinaThe incidence of gastric cardia cancer (GCC) is high in China. However, the clinicopathological characteristics and the carcinogenesis of GCC are unclear. Toll-like receptor 4 (TLR4) is an important innate immunity receptor and has a role in non-GCC (NGCC). We compared the clinicopathological characteristics of GCC patients from a high-risk area in China to esophageal cancer (EC) patients. Immunohistochemistry for TLR4 was performed in 201 histological samples of normal gastric cardia mucosa (n=11), gastric cardia inflammation (n=87), and GCC (n=103). We included 84 patients with EC and 99 with GCC. GCC tissue was more poorly differentiated than EC tissue and more invasive, with more histomorphologic variation. Lymph node metastasis was more frequent in GCC than in EC. The Helicobacter pylori infection rate was higher but not significantly with GCC than EC. Survival was shorter with lymph node metastasis. We found a statistically significant trend for progressive increase of TLR4 expression from normal mucosa to inflammation in GCC. GCC in this high-risk area displays clinicopathologic characteristics different from those of EC and different from those of gastroesophageal junction carcinomas in other countries, although this was not analyzed statistically. Increased TLR4 expression in gastric cardia lesions may be associated with GCC tumorigenesis.http://dx.doi.org/10.1155/2018/7132868 |
| spellingShingle | Guangcan Chen Muming Xu Jingyao Chen Liangli Hong Wenting Lin Shukun Zhao Guohong Zhang Guo Dan Shuhui Liu Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population Journal of Immunology Research |
| title | Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population |
| title_full | Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population |
| title_fullStr | Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population |
| title_full_unstemmed | Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population |
| title_short | Clinicopathological Features and Increased Expression of Toll-Like Receptor 4 of Gastric Cardia Cancer in a High-Risk Chinese Population |
| title_sort | clinicopathological features and increased expression of toll like receptor 4 of gastric cardia cancer in a high risk chinese population |
| url | http://dx.doi.org/10.1155/2018/7132868 |
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