<i>Legionella pneumophila</i>—<i>Klebsiella pneumoniae</i> Pulmonary Coinfection in a COVID-19 Patient: Case Report
<b>Background.</b> Pulmonary superinfections increase the mortality risk among COVID-19 patients, highlighting the need for enhanced understanding to enable early and accurate diagnosis. <b>Methods.</b> We present the case of a patient, a 76-year-old man, hospitalized for a s...
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2024-11-01
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| Online Access: | https://www.mdpi.com/2036-7449/16/6/85 |
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| author | Maria Irina Brumboiu Edina Iuga Andreea Ivanciuc Irina Iaru Alexandru Durla-Pașca Pavel Șchiopu Adrian Gabriel Pană |
| author_facet | Maria Irina Brumboiu Edina Iuga Andreea Ivanciuc Irina Iaru Alexandru Durla-Pașca Pavel Șchiopu Adrian Gabriel Pană |
| author_sort | Maria Irina Brumboiu |
| collection | DOAJ |
| description | <b>Background.</b> Pulmonary superinfections increase the mortality risk among COVID-19 patients, highlighting the need for enhanced understanding to enable early and accurate diagnosis. <b>Methods.</b> We present the case of a patient, a 76-year-old man, hospitalized for a severe form of COVID-19, with a ground-glass pneumonia, involving 40–45% of lung surfaces. <b>Results.</b> In evolution, the clinical condition worsened, presenting leukocytosis with neutrophilia, imaging towards resorption, and computer tomography images showing the appearance of pulmonary condensations in the right lower lobe, the posterior portion of the left lower lobe and pleural collections. Carbapenemase-producing <i>Klebsiella pneumoniae</i> was isolated from the tracheal aspirate, and the real-time polymerase chain reaction test was positive for <i>Klebsiella pneumoniae</i> and <i>Legionella pneumophila</i>. The investigations that were carried out allowed us to establish the coinfections as a probable case of Legionnaire’s disease and a ventilator-associated pneumonia with <i>Klebsiella pneumoniae</i>. <b>Conclusions.</b> The case analysis revealed that rare pneumonias may remain undiagnosed, and coinfections may be conditioned by pathophysiological factors or components of COVID-19 critical form treatment. Enhanced understanding of these aspects in clinical practice may contribute to reducing mortality risk in COVID-19 patients. |
| format | Article |
| id | doaj-art-4dcd0dc1b7fd4ea0bbbada89837bbfbb |
| institution | DOAJ |
| issn | 2036-7449 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
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| series | Infectious Disease Reports |
| spelling | doaj-art-4dcd0dc1b7fd4ea0bbbada89837bbfbb2025-08-20T02:55:57ZengMDPI AGInfectious Disease Reports2036-74492024-11-011661055106310.3390/idr16060085<i>Legionella pneumophila</i>—<i>Klebsiella pneumoniae</i> Pulmonary Coinfection in a COVID-19 Patient: Case ReportMaria Irina Brumboiu0Edina Iuga1Andreea Ivanciuc2Irina Iaru3Alexandru Durla-Pașca4Pavel Șchiopu5Adrian Gabriel Pană6Medical Specialties Department, Iuliu Hatieganu University of Medicine and Pharmacy, 400 012 Cluj-Napoca, RomaniaMedical Specialties Department, Iuliu Hatieganu University of Medicine and Pharmacy, 400 012 Cluj-Napoca, RomaniaMedical Specialties Department, Iuliu Hatieganu University of Medicine and Pharmacy, 400 012 Cluj-Napoca, RomaniaCluj Unit, French-Speaking International Clinical Epidemiology Network, Iuliu Hatieganu University of Medicine and Pharmacy, 400 012 Cluj-Napoca, RomaniaMedical Specialties Department, Iuliu Hatieganu University of Medicine and Pharmacy, 400 012 Cluj-Napoca, RomaniaMicrobiology Department, Iuliu Hatieganu University of Medicine and Pharmacy, 400 012 Cluj-Napoca, RomaniaMedical Specialties Department, Iuliu Hatieganu University of Medicine and Pharmacy, 400 012 Cluj-Napoca, Romania<b>Background.</b> Pulmonary superinfections increase the mortality risk among COVID-19 patients, highlighting the need for enhanced understanding to enable early and accurate diagnosis. <b>Methods.</b> We present the case of a patient, a 76-year-old man, hospitalized for a severe form of COVID-19, with a ground-glass pneumonia, involving 40–45% of lung surfaces. <b>Results.</b> In evolution, the clinical condition worsened, presenting leukocytosis with neutrophilia, imaging towards resorption, and computer tomography images showing the appearance of pulmonary condensations in the right lower lobe, the posterior portion of the left lower lobe and pleural collections. Carbapenemase-producing <i>Klebsiella pneumoniae</i> was isolated from the tracheal aspirate, and the real-time polymerase chain reaction test was positive for <i>Klebsiella pneumoniae</i> and <i>Legionella pneumophila</i>. The investigations that were carried out allowed us to establish the coinfections as a probable case of Legionnaire’s disease and a ventilator-associated pneumonia with <i>Klebsiella pneumoniae</i>. <b>Conclusions.</b> The case analysis revealed that rare pneumonias may remain undiagnosed, and coinfections may be conditioned by pathophysiological factors or components of COVID-19 critical form treatment. Enhanced understanding of these aspects in clinical practice may contribute to reducing mortality risk in COVID-19 patients.https://www.mdpi.com/2036-7449/16/6/85pneumonia<i>Legionella pneumophila</i><i>Klebsiella pneumoniae</i>COVID-19coinfectioncase report |
| spellingShingle | Maria Irina Brumboiu Edina Iuga Andreea Ivanciuc Irina Iaru Alexandru Durla-Pașca Pavel Șchiopu Adrian Gabriel Pană <i>Legionella pneumophila</i>—<i>Klebsiella pneumoniae</i> Pulmonary Coinfection in a COVID-19 Patient: Case Report Infectious Disease Reports pneumonia <i>Legionella pneumophila</i> <i>Klebsiella pneumoniae</i> COVID-19 coinfection case report |
| title | <i>Legionella pneumophila</i>—<i>Klebsiella pneumoniae</i> Pulmonary Coinfection in a COVID-19 Patient: Case Report |
| title_full | <i>Legionella pneumophila</i>—<i>Klebsiella pneumoniae</i> Pulmonary Coinfection in a COVID-19 Patient: Case Report |
| title_fullStr | <i>Legionella pneumophila</i>—<i>Klebsiella pneumoniae</i> Pulmonary Coinfection in a COVID-19 Patient: Case Report |
| title_full_unstemmed | <i>Legionella pneumophila</i>—<i>Klebsiella pneumoniae</i> Pulmonary Coinfection in a COVID-19 Patient: Case Report |
| title_short | <i>Legionella pneumophila</i>—<i>Klebsiella pneumoniae</i> Pulmonary Coinfection in a COVID-19 Patient: Case Report |
| title_sort | i legionella pneumophila i i klebsiella pneumoniae i pulmonary coinfection in a covid 19 patient case report |
| topic | pneumonia <i>Legionella pneumophila</i> <i>Klebsiella pneumoniae</i> COVID-19 coinfection case report |
| url | https://www.mdpi.com/2036-7449/16/6/85 |
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