Beta-Human Chorionic Gonadotropin Producing Osteosarcoma of the Sacrum in a 26-Year-Old Woman: A Case Report and Review of the Literature
Ectopic secretion of beta-human chorionic gonadotropin is considered a poor prognostic marker in epithelial tumors. However, very few cases have been reported in sarcomas. We present the case of a 26-year-old female who presented with a metastatic osteosarcoma. She underwent usual testing prior to s...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Pathology |
| Online Access: | http://dx.doi.org/10.1155/2015/897230 |
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| author | Ryan Glass Jaya Ruth Asirvatham Leonard Kahn Mohamed Aziz |
| author_facet | Ryan Glass Jaya Ruth Asirvatham Leonard Kahn Mohamed Aziz |
| author_sort | Ryan Glass |
| collection | DOAJ |
| description | Ectopic secretion of beta-human chorionic gonadotropin is considered a poor prognostic marker in epithelial tumors. However, very few cases have been reported in sarcomas. We present the case of a 26-year-old female who presented with a metastatic osteosarcoma. She underwent usual testing prior to starting treatment and was found to have elevated levels of beta-human chorionic gonadotropin. As the patient was not pregnant, another source of beta-human chorionic gonadotropin secretion had to be considered. The tumor cells demonstrated positive staining for beta-human chorionic gonadotropin by immunohistochemistry, and serum levels of beta-human chorionic gonadotropin were used to monitor tumor progression and response to chemotherapy. We review the literature and discuss a potential role of beta-human chorionic gonadotropin in the treatment of such patients. |
| format | Article |
| id | doaj-art-4dc42fb9cb6b4ea7ad22d6873c559fad |
| institution | Kabale University |
| issn | 2090-6781 2090-679X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Pathology |
| spelling | doaj-art-4dc42fb9cb6b4ea7ad22d6873c559fad2025-02-03T00:59:10ZengWileyCase Reports in Pathology2090-67812090-679X2015-01-01201510.1155/2015/897230897230Beta-Human Chorionic Gonadotropin Producing Osteosarcoma of the Sacrum in a 26-Year-Old Woman: A Case Report and Review of the LiteratureRyan Glass0Jaya Ruth Asirvatham1Leonard Kahn2Mohamed Aziz3Department of Pathology, North Shore Long Island Jewish, New Hyde Park, NY 11040, USADepartment of Pathology, North Shore Long Island Jewish, New Hyde Park, NY 11040, USADepartment of Pathology, North Shore Long Island Jewish, New Hyde Park, NY 11040, USADepartment of Pathology, North Shore Long Island Jewish, New Hyde Park, NY 11040, USAEctopic secretion of beta-human chorionic gonadotropin is considered a poor prognostic marker in epithelial tumors. However, very few cases have been reported in sarcomas. We present the case of a 26-year-old female who presented with a metastatic osteosarcoma. She underwent usual testing prior to starting treatment and was found to have elevated levels of beta-human chorionic gonadotropin. As the patient was not pregnant, another source of beta-human chorionic gonadotropin secretion had to be considered. The tumor cells demonstrated positive staining for beta-human chorionic gonadotropin by immunohistochemistry, and serum levels of beta-human chorionic gonadotropin were used to monitor tumor progression and response to chemotherapy. We review the literature and discuss a potential role of beta-human chorionic gonadotropin in the treatment of such patients.http://dx.doi.org/10.1155/2015/897230 |
| spellingShingle | Ryan Glass Jaya Ruth Asirvatham Leonard Kahn Mohamed Aziz Beta-Human Chorionic Gonadotropin Producing Osteosarcoma of the Sacrum in a 26-Year-Old Woman: A Case Report and Review of the Literature Case Reports in Pathology |
| title | Beta-Human Chorionic Gonadotropin Producing Osteosarcoma of the Sacrum in a 26-Year-Old Woman: A Case Report and Review of the Literature |
| title_full | Beta-Human Chorionic Gonadotropin Producing Osteosarcoma of the Sacrum in a 26-Year-Old Woman: A Case Report and Review of the Literature |
| title_fullStr | Beta-Human Chorionic Gonadotropin Producing Osteosarcoma of the Sacrum in a 26-Year-Old Woman: A Case Report and Review of the Literature |
| title_full_unstemmed | Beta-Human Chorionic Gonadotropin Producing Osteosarcoma of the Sacrum in a 26-Year-Old Woman: A Case Report and Review of the Literature |
| title_short | Beta-Human Chorionic Gonadotropin Producing Osteosarcoma of the Sacrum in a 26-Year-Old Woman: A Case Report and Review of the Literature |
| title_sort | beta human chorionic gonadotropin producing osteosarcoma of the sacrum in a 26 year old woman a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2015/897230 |
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