A resource of longitudinal RNA-seq data of Holstein cow rumen, duodenum, and colon epithelial cells during the lactation cycle
Abstract Objective As one of the most important ruminant breeds, Holstein cattle supply a significant portion of milk and dairy for human consumption, playing a crucial role in agribusiness. The goal of our study was to examine the molecular adaptation of gastrointestinal tissues that facilitate mil...
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2025-01-01
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| Series: | BMC Genomic Data |
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| Online Access: | https://doi.org/10.1186/s12863-025-01295-5 |
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| author | Yahui Gao George E. Liu Li Ma Cong-jun Li Ransom L Baldwin |
| author_facet | Yahui Gao George E. Liu Li Ma Cong-jun Li Ransom L Baldwin |
| author_sort | Yahui Gao |
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| description | Abstract Objective As one of the most important ruminant breeds, Holstein cattle supply a significant portion of milk and dairy for human consumption, playing a crucial role in agribusiness. The goal of our study was to examine the molecular adaptation of gastrointestinal tissues that facilitate milk synthesis in dairy cattle. Data description We performed RNA-seq analysis on epithelial cells from the rumen, duodenum, and colon at eight different time points: Days 3, 14, 28, 45, 120, 220, and 305 in milk, as well as the dry period. Samples were taken from five multiparous dairy cows as biological replicates per tissue per stage, except for Days 14 and 28, for which the sample size was three. These tissues each serve critical and distinct roles in the digestion and absorption of nutrients and are all vital for providing the necessary substrates required for milk production. Understanding the intricate connections between the tissues involved in providing nutrients necessary to support milk synthesis and their role in digestion can deepen the understanding of lactation physiology. This resource aims to deliver in-depth insights into cattle lactation, highlighting the distinct traits of gastrointestinal tissues and illuminating the intricate transcriptomic dynamics throughout the lactation period. |
| format | Article |
| id | doaj-art-4dc2d34b39584c2f9a9c7fc26c6a0224 |
| institution | Kabale University |
| issn | 2730-6844 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
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| series | BMC Genomic Data |
| spelling | doaj-art-4dc2d34b39584c2f9a9c7fc26c6a02242025-02-02T12:44:35ZengBMCBMC Genomic Data2730-68442025-01-012611410.1186/s12863-025-01295-5A resource of longitudinal RNA-seq data of Holstein cow rumen, duodenum, and colon epithelial cells during the lactation cycleYahui Gao0George E. Liu1Li Ma2Cong-jun Li3Ransom L Baldwin4Animal Genomics and Improvement Laboratory, BARC, Agricultural Research Service, USDAAnimal Genomics and Improvement Laboratory, BARC, Agricultural Research Service, USDADepartment of Animal and Avian Sciences, University of MarylandAnimal Genomics and Improvement Laboratory, BARC, Agricultural Research Service, USDAAnimal Genomics and Improvement Laboratory, BARC, Agricultural Research Service, USDAAbstract Objective As one of the most important ruminant breeds, Holstein cattle supply a significant portion of milk and dairy for human consumption, playing a crucial role in agribusiness. The goal of our study was to examine the molecular adaptation of gastrointestinal tissues that facilitate milk synthesis in dairy cattle. Data description We performed RNA-seq analysis on epithelial cells from the rumen, duodenum, and colon at eight different time points: Days 3, 14, 28, 45, 120, 220, and 305 in milk, as well as the dry period. Samples were taken from five multiparous dairy cows as biological replicates per tissue per stage, except for Days 14 and 28, for which the sample size was three. These tissues each serve critical and distinct roles in the digestion and absorption of nutrients and are all vital for providing the necessary substrates required for milk production. Understanding the intricate connections between the tissues involved in providing nutrients necessary to support milk synthesis and their role in digestion can deepen the understanding of lactation physiology. This resource aims to deliver in-depth insights into cattle lactation, highlighting the distinct traits of gastrointestinal tissues and illuminating the intricate transcriptomic dynamics throughout the lactation period.https://doi.org/10.1186/s12863-025-01295-5Holstein cattleGene expressionGastrointestinal tract tissuesLactationFunctional genomeMolecular genetics |
| spellingShingle | Yahui Gao George E. Liu Li Ma Cong-jun Li Ransom L Baldwin A resource of longitudinal RNA-seq data of Holstein cow rumen, duodenum, and colon epithelial cells during the lactation cycle BMC Genomic Data Holstein cattle Gene expression Gastrointestinal tract tissues Lactation Functional genome Molecular genetics |
| title | A resource of longitudinal RNA-seq data of Holstein cow rumen, duodenum, and colon epithelial cells during the lactation cycle |
| title_full | A resource of longitudinal RNA-seq data of Holstein cow rumen, duodenum, and colon epithelial cells during the lactation cycle |
| title_fullStr | A resource of longitudinal RNA-seq data of Holstein cow rumen, duodenum, and colon epithelial cells during the lactation cycle |
| title_full_unstemmed | A resource of longitudinal RNA-seq data of Holstein cow rumen, duodenum, and colon epithelial cells during the lactation cycle |
| title_short | A resource of longitudinal RNA-seq data of Holstein cow rumen, duodenum, and colon epithelial cells during the lactation cycle |
| title_sort | resource of longitudinal rna seq data of holstein cow rumen duodenum and colon epithelial cells during the lactation cycle |
| topic | Holstein cattle Gene expression Gastrointestinal tract tissues Lactation Functional genome Molecular genetics |
| url | https://doi.org/10.1186/s12863-025-01295-5 |
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