Detection of Salivary Interleukin 2 and Interleukin 6 in Patients With Burning Mouth Syndrome
<p>The etiology of BMS remains unknown. Role of various cytokines has been implicated in the development of BMS. The aim of this study was to evaluate levels of salivary IL-2 and IL-6 in patients with BMS, compared with age-matched healthy volunteers (control group). Whole saliva from 30 patie...
Saved in:
| Format: | Article |
|---|---|
| Language: | English |
| Published: |
Wiley
2006-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://www.hindawi.com/GetArticle.aspx?doi=10.1155/MI/2006/54632 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | <p>The etiology of BMS remains unknown. Role of various cytokines has been implicated in the development of BMS. The aim of this study was to evaluate levels of salivary IL-2 and IL-6 in patients with BMS, compared with age-matched healthy volunteers (control group). Whole saliva from 30 patients with BMS, age range 55–65, was tested for the presence of IL-6 and IL-2 by enzyme immunoassay. Control group consisted of 30 healthy participants, aged 55–65 years. Saliva IL-2 concentrations in BMS were significantly increased in patients compared to healthy subjects: mean <mml:math alttext="$34.1 pm 9.7$"> <mml:mrow> <mml:mn>34.1</mml:mn> <mml:mo>±</mml:mo> <mml:mn>9.7</mml:mn> </mml:mrow> </mml:math> versus <mml:math alttext="$7.3 pm 3.0$"> <mml:mrow> <mml:mn>7.3</mml:mn> <mml:mo>±</mml:mo> <mml:mn>3.0</mml:mn> </mml:mrow> </mml:math> pg/mL; <mml:math alttext="$cmathcheck{P<.001}$"> <mml:mrow> <mml:mi>P</mml:mi> <mml:mo><</mml:mo> <mml:mn>.001</mml:mn> </mml:mrow> </mml:math>. Patients with BMS had significantly higher concentrations of IL-6 compared to control: mean <mml:math alttext="$30.8 pm 5.6$"> <mml:mrow> <mml:mn>30.8</mml:mn> <mml:mo>±</mml:mo> <mml:mn>5.6</mml:mn> </mml:mrow> </mml:math> versus <mml:math alttext="$5.2 pm 2.8$"> <mml:mrow> <mml:mn>5.2</mml:mn> <mml:mo>±</mml:mo> <mml:mn>2.8</mml:mn> </mml:mrow> </mml:math> pg/mL; <mml:math alttext="$cmathcheck{P<.001}$"> <mml:mrow> <mml:mi>P</mml:mi> <mml:mo><</mml:mo> <mml:mn>.001</mml:mn> </mml:mrow> </mml:math>. In patients with BMS, IL-2 and IL-6 levels in saliva are elevated, correlating with the severity of illness.</p> |
|---|---|
| ISSN: | 0962-9351 |