Upper Limb Deep Vein Thrombosis in Patient with Hemophilia A and Heterozygosity for Prothrombin G20210A: A Case Report and Review of the Literature
Deep vein thrombosis (DVT) is a rare disease in patients with hemophilia A. We report a case of 22-year-old male with severe hemophilia A who presented to the emergency room with 5-day history of right arm pain that was attributed initially to bleeding event. In the absence of external signs of blee...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2017/7290945 |
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| author | Fares Darawshy Yosef Kalish Issam Hendi Ayman Abu Rmelieh Tawfik Khoury |
| author_facet | Fares Darawshy Yosef Kalish Issam Hendi Ayman Abu Rmelieh Tawfik Khoury |
| author_sort | Fares Darawshy |
| collection | DOAJ |
| description | Deep vein thrombosis (DVT) is a rare disease in patients with hemophilia A. We report a case of 22-year-old male with severe hemophilia A who presented to the emergency room with 5-day history of right arm pain that was attributed initially to bleeding event. In the absence of external signs of bleeding or hematoma and normal hemoglobin level, we suspected an underlying DVT. Doppler ultrasonography of the right upper limb revealed thrombosis of the subclavian vein and this was confirmed by CT venography. The d-dimer level was normal and investigations for prothrombotic state revealed heterozygosity for prothrombin G20210A mutation. Treatment with factor VIII and low molecular weight heparin led to successful resolution and marked improvement of his clinical condition. |
| format | Article |
| id | doaj-art-4db94bc9ddef4dab97842559681538a1 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-4db94bc9ddef4dab97842559681538a12025-02-03T07:25:21ZengWileyCase Reports in Hematology2090-65602090-65792017-01-01201710.1155/2017/72909457290945Upper Limb Deep Vein Thrombosis in Patient with Hemophilia A and Heterozygosity for Prothrombin G20210A: A Case Report and Review of the LiteratureFares Darawshy0Yosef Kalish1Issam Hendi2Ayman Abu Rmelieh3Tawfik Khoury4Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, IsraelDepartment of Hematology, Hadassah-Hebrew University Medical Center, Jerusalem, IsraelDepartment of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, IsraelDepartment of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, IsraelDepartment of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, IsraelDeep vein thrombosis (DVT) is a rare disease in patients with hemophilia A. We report a case of 22-year-old male with severe hemophilia A who presented to the emergency room with 5-day history of right arm pain that was attributed initially to bleeding event. In the absence of external signs of bleeding or hematoma and normal hemoglobin level, we suspected an underlying DVT. Doppler ultrasonography of the right upper limb revealed thrombosis of the subclavian vein and this was confirmed by CT venography. The d-dimer level was normal and investigations for prothrombotic state revealed heterozygosity for prothrombin G20210A mutation. Treatment with factor VIII and low molecular weight heparin led to successful resolution and marked improvement of his clinical condition.http://dx.doi.org/10.1155/2017/7290945 |
| spellingShingle | Fares Darawshy Yosef Kalish Issam Hendi Ayman Abu Rmelieh Tawfik Khoury Upper Limb Deep Vein Thrombosis in Patient with Hemophilia A and Heterozygosity for Prothrombin G20210A: A Case Report and Review of the Literature Case Reports in Hematology |
| title | Upper Limb Deep Vein Thrombosis in Patient with Hemophilia A and Heterozygosity for Prothrombin G20210A: A Case Report and Review of the Literature |
| title_full | Upper Limb Deep Vein Thrombosis in Patient with Hemophilia A and Heterozygosity for Prothrombin G20210A: A Case Report and Review of the Literature |
| title_fullStr | Upper Limb Deep Vein Thrombosis in Patient with Hemophilia A and Heterozygosity for Prothrombin G20210A: A Case Report and Review of the Literature |
| title_full_unstemmed | Upper Limb Deep Vein Thrombosis in Patient with Hemophilia A and Heterozygosity for Prothrombin G20210A: A Case Report and Review of the Literature |
| title_short | Upper Limb Deep Vein Thrombosis in Patient with Hemophilia A and Heterozygosity for Prothrombin G20210A: A Case Report and Review of the Literature |
| title_sort | upper limb deep vein thrombosis in patient with hemophilia a and heterozygosity for prothrombin g20210a a case report and review of the literature |
| url | http://dx.doi.org/10.1155/2017/7290945 |
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