Hypoglycemic activity of brown seaweed (Sargassum plagiophyllum) kombucha bioactive compound in rat model type-2 of diabetes
Hyperglycemia is a condition of increased blood glucose with out of normal limits criteria associated with diabetes mellitus. Uncontrolled hyperglycemia is one of the causes of complications in diabetes mellitus sufferers. Sargassum plagiophyllum is one of brown seaweed that contains many bioactive...
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EDP Sciences
2025-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2025/05/bioconf_icgrc2025_02009.pdf |
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| author | Priambodo Ahmad Faris Martati Erryana Firdaus Muhamad |
| author_facet | Priambodo Ahmad Faris Martati Erryana Firdaus Muhamad |
| author_sort | Priambodo Ahmad Faris |
| collection | DOAJ |
| description | Hyperglycemia is a condition of increased blood glucose with out of normal limits criteria associated with diabetes mellitus. Uncontrolled hyperglycemia is one of the causes of complications in diabetes mellitus sufferers. Sargassum plagiophyllum is one of brown seaweed that contains many bioactive compounds which are useful as hypoglycemic agents. The kombucha fermentation method is used to reduce structural complexity, thereby increasing the bioavailability of bioactives. This study aims to evaluate the administration of S. plagiophyllum kombucha (SK) to the blood profile of type 2 diabetes mellitus (DM2) rats treated with a 21% highfructose diet (HFD) with normal feed. S. plagiophyllum was obtained from Talango, Sumenep, Madura Island, East Java Province. 2-month-old male Rattus norvegicus was used as a model animal. The study consisted of 5 groups, including negative control, positive control (DM2), DM2 + SK 1.5 mL/250 g bw once a day, DM2 + SK 1.5 mL/250 g bw twice a day, and DM2 + SK 1, 5 mL/250 g bw three times a day. Animal model research was carried out for 2 months. The study’s conclusion shows that S. plagiophyllum kombucha has bioactive compounds as hypoglycemic agents and contributes to improving body weight, fasting blood glucose (FBG), lipid profiles, insulin, and MDA in type-2 diabetes rats model. |
| format | Article |
| id | doaj-art-4da6a04920bf4cc0955ca5e0484aaef8 |
| institution | Kabale University |
| issn | 2117-4458 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj-art-4da6a04920bf4cc0955ca5e0484aaef82025-02-05T10:43:07ZengEDP SciencesBIO Web of Conferences2117-44582025-01-011540200910.1051/bioconf/202515402009bioconf_icgrc2025_02009Hypoglycemic activity of brown seaweed (Sargassum plagiophyllum) kombucha bioactive compound in rat model type-2 of diabetesPriambodo Ahmad Faris0Martati Erryana1Firdaus Muhamad2Departement of Food Science and Biotechnology, Faculty of Agricultural Technology, Brawijaya UniversityDepartement of Food Science and Biotechnology, Faculty of Agricultural Technology, Brawijaya UniversityDepartment of Fisheries and Marine Resources Management, Faculty of Fisheries and Marine Science, Brawijaya UniversityHyperglycemia is a condition of increased blood glucose with out of normal limits criteria associated with diabetes mellitus. Uncontrolled hyperglycemia is one of the causes of complications in diabetes mellitus sufferers. Sargassum plagiophyllum is one of brown seaweed that contains many bioactive compounds which are useful as hypoglycemic agents. The kombucha fermentation method is used to reduce structural complexity, thereby increasing the bioavailability of bioactives. This study aims to evaluate the administration of S. plagiophyllum kombucha (SK) to the blood profile of type 2 diabetes mellitus (DM2) rats treated with a 21% highfructose diet (HFD) with normal feed. S. plagiophyllum was obtained from Talango, Sumenep, Madura Island, East Java Province. 2-month-old male Rattus norvegicus was used as a model animal. The study consisted of 5 groups, including negative control, positive control (DM2), DM2 + SK 1.5 mL/250 g bw once a day, DM2 + SK 1.5 mL/250 g bw twice a day, and DM2 + SK 1, 5 mL/250 g bw three times a day. Animal model research was carried out for 2 months. The study’s conclusion shows that S. plagiophyllum kombucha has bioactive compounds as hypoglycemic agents and contributes to improving body weight, fasting blood glucose (FBG), lipid profiles, insulin, and MDA in type-2 diabetes rats model.https://www.bio-conferences.org/articles/bioconf/pdf/2025/05/bioconf_icgrc2025_02009.pdf |
| spellingShingle | Priambodo Ahmad Faris Martati Erryana Firdaus Muhamad Hypoglycemic activity of brown seaweed (Sargassum plagiophyllum) kombucha bioactive compound in rat model type-2 of diabetes BIO Web of Conferences |
| title | Hypoglycemic activity of brown seaweed (Sargassum plagiophyllum) kombucha bioactive compound in rat model type-2 of diabetes |
| title_full | Hypoglycemic activity of brown seaweed (Sargassum plagiophyllum) kombucha bioactive compound in rat model type-2 of diabetes |
| title_fullStr | Hypoglycemic activity of brown seaweed (Sargassum plagiophyllum) kombucha bioactive compound in rat model type-2 of diabetes |
| title_full_unstemmed | Hypoglycemic activity of brown seaweed (Sargassum plagiophyllum) kombucha bioactive compound in rat model type-2 of diabetes |
| title_short | Hypoglycemic activity of brown seaweed (Sargassum plagiophyllum) kombucha bioactive compound in rat model type-2 of diabetes |
| title_sort | hypoglycemic activity of brown seaweed sargassum plagiophyllum kombucha bioactive compound in rat model type 2 of diabetes |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2025/05/bioconf_icgrc2025_02009.pdf |
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