Chimeric autoantibody receptor T cells specifically eliminate Graves’ Disease autoreactive B cells

Chimeric autoantibody receptor T cells specifically eliminate Graves’ Disease autoreactive B cells

IntroductionChimeric antigen receptor (CAR) T cells have recently become an important treatment for hematological cancers by efficiently eliminating B cells. B cell depleting CAR T cells are also in clinical trials for their use in treating severe autoimmune diseases and have shown promise in patien...

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Bibliographic Details
Main Authors: Abigail Cheever, Hunter G. Lindsay, Chloe C. Kang, Mackenzie Hansen, Kimball Demars, Kim L. O’Neill, K. Scott Weber
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
CAR T cell
Graves’ disease
autoimmunity
autoantibody
autoantigen
CAAR T cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1562662/full
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