Individual-network based predictions of microbial interaction signatures for response to biological therapies in IBD patients

Individual-network based predictions of microbial interaction signatures for response to biological therapies in IBD patients

Inflammatory Bowel Disease (IBD), which includes Ulcerative Colitis (UC) and Crohn’s Disease (CD), is marked by dysbiosis of the gut microbiome. Despite therapeutic interventions with biological agents like Vedolizumab, Ustekinumab, and anti-TNF agents, the variability in clinical, histological, and...

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Main Authors: Federico Melograna, Padhmanand Sudhakar, Behnam Yousefi, Clara Caenepeel, Gwen Falony, Sara Vieira-Silva, Sreenikhitha Krishnamoorthy, David Fardo, Bram Verstockt, Jeroen Raes, Severine Vermeire, Kristel Van Steen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Molecular Biosciences
Subjects:
inflammatory bowel disease
therapy
fecal microbiota
16S profiling
individual specific networks
response prediction
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2024.1490533/full
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https://www.frontiersin.org/articles/10.3389/fmolb.2024.1490533/full

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