Trends in Glycemia between 2002 and 2016 among Incident Youth Cohorts Early in the Course of Type 1 Diabetes: The SEARCH for Diabetes in Youth Study
Objective. Hyperglycemia early in the course of type 1 diabetes (T1D) may increase the risk of cardiometabolic complications later in life. We tested the hypothesis that there were temporal trends in population-level glycemia and insulin pump use near T1D diagnosis among incident youth cohorts diagn...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2022/8554991 |
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| author | Daria Igudesman Beth A. Reboussin Katherine J. Souris Catherine Pihoker Lawrence Dolan Jean M. Lawrence Sharon Saydah Dana Dabelea Santica Marcovina Noémie Clouet-Foraison Faisal S. Malik Elizabeth J. Mayer-Davis |
| author_facet | Daria Igudesman Beth A. Reboussin Katherine J. Souris Catherine Pihoker Lawrence Dolan Jean M. Lawrence Sharon Saydah Dana Dabelea Santica Marcovina Noémie Clouet-Foraison Faisal S. Malik Elizabeth J. Mayer-Davis |
| author_sort | Daria Igudesman |
| collection | DOAJ |
| description | Objective. Hyperglycemia early in the course of type 1 diabetes (T1D) may increase the risk of cardiometabolic complications later in life. We tested the hypothesis that there were temporal trends in population-level glycemia and insulin pump use near T1D diagnosis among incident youth cohorts diagnosed between 2002 and 2016. Methods. Weighted and adjusted regression models were applied to data from the SEARCH for Diabetes in Youth study to analyze trends in hemoglobin A1c (HbA1c), suboptimal glycemia (HbA1c>9% or not), and insulin pump use among youth with T1D within 30 months of diagnosis. We tested the interaction of year with race and ethnicity, sex, and insulin regimen to assess potential disparities. Results. Among the 3,956 youth with T1D, there was a small, clinically insignificant reduction in HbA1c between 2002 (7.9%±1.5) and 2016 (7.8%±2.4) (fully adjusted change by year (-0.013% [95% CI -0.026, -0.0008], p=0.04). The proportion of youth with suboptimal glycemia increased with each year, but the adjusted odds did not change. Insulin pump use increased more than fivefold. Although interaction effects of time with race and ethnicity, sex, and insulin regimen were not detected, in 2016, suboptimal glycemia was 4.3 and 1.8 times more prevalent among Black and Hispanic than among non-Hispanic White youth, respectively. Conclusions. There was not a clinically significant population-level improvement in glycemia across incident youth cohorts early in the course of T1D, despite severalfold increases in insulin pump use. Comprehensive clinical interventions to improve glycemia early in the T1D course and address disparities are urgently needed. |
| format | Article |
| id | doaj-art-4d8659cd5ad94310bd1099f123f152e9 |
| institution | Kabale University |
| issn | 2314-6753 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-4d8659cd5ad94310bd1099f123f152e92025-02-03T06:04:45ZengWileyJournal of Diabetes Research2314-67532022-01-01202210.1155/2022/8554991Trends in Glycemia between 2002 and 2016 among Incident Youth Cohorts Early in the Course of Type 1 Diabetes: The SEARCH for Diabetes in Youth StudyDaria Igudesman0Beth A. Reboussin1Katherine J. Souris2Catherine Pihoker3Lawrence Dolan4Jean M. Lawrence5Sharon Saydah6Dana Dabelea7Santica Marcovina8Noémie Clouet-Foraison9Faisal S. Malik10Elizabeth J. Mayer-Davis11Department of NutritionDepartment of Biostatistics and Data ScienceDepartment of NutritionDepartment of PediatricsDivision of EndocrinologyDepartment of Research & EvaluationDivision of Diabetes TranslationDepartment of EpidemiologyDivision of MetabolismDivision of MetabolismDepartment of PediatricsDepartment of NutritionObjective. Hyperglycemia early in the course of type 1 diabetes (T1D) may increase the risk of cardiometabolic complications later in life. We tested the hypothesis that there were temporal trends in population-level glycemia and insulin pump use near T1D diagnosis among incident youth cohorts diagnosed between 2002 and 2016. Methods. Weighted and adjusted regression models were applied to data from the SEARCH for Diabetes in Youth study to analyze trends in hemoglobin A1c (HbA1c), suboptimal glycemia (HbA1c>9% or not), and insulin pump use among youth with T1D within 30 months of diagnosis. We tested the interaction of year with race and ethnicity, sex, and insulin regimen to assess potential disparities. Results. Among the 3,956 youth with T1D, there was a small, clinically insignificant reduction in HbA1c between 2002 (7.9%±1.5) and 2016 (7.8%±2.4) (fully adjusted change by year (-0.013% [95% CI -0.026, -0.0008], p=0.04). The proportion of youth with suboptimal glycemia increased with each year, but the adjusted odds did not change. Insulin pump use increased more than fivefold. Although interaction effects of time with race and ethnicity, sex, and insulin regimen were not detected, in 2016, suboptimal glycemia was 4.3 and 1.8 times more prevalent among Black and Hispanic than among non-Hispanic White youth, respectively. Conclusions. There was not a clinically significant population-level improvement in glycemia across incident youth cohorts early in the course of T1D, despite severalfold increases in insulin pump use. Comprehensive clinical interventions to improve glycemia early in the T1D course and address disparities are urgently needed.http://dx.doi.org/10.1155/2022/8554991 |
| spellingShingle | Daria Igudesman Beth A. Reboussin Katherine J. Souris Catherine Pihoker Lawrence Dolan Jean M. Lawrence Sharon Saydah Dana Dabelea Santica Marcovina Noémie Clouet-Foraison Faisal S. Malik Elizabeth J. Mayer-Davis Trends in Glycemia between 2002 and 2016 among Incident Youth Cohorts Early in the Course of Type 1 Diabetes: The SEARCH for Diabetes in Youth Study Journal of Diabetes Research |
| title | Trends in Glycemia between 2002 and 2016 among Incident Youth Cohorts Early in the Course of Type 1 Diabetes: The SEARCH for Diabetes in Youth Study |
| title_full | Trends in Glycemia between 2002 and 2016 among Incident Youth Cohorts Early in the Course of Type 1 Diabetes: The SEARCH for Diabetes in Youth Study |
| title_fullStr | Trends in Glycemia between 2002 and 2016 among Incident Youth Cohorts Early in the Course of Type 1 Diabetes: The SEARCH for Diabetes in Youth Study |
| title_full_unstemmed | Trends in Glycemia between 2002 and 2016 among Incident Youth Cohorts Early in the Course of Type 1 Diabetes: The SEARCH for Diabetes in Youth Study |
| title_short | Trends in Glycemia between 2002 and 2016 among Incident Youth Cohorts Early in the Course of Type 1 Diabetes: The SEARCH for Diabetes in Youth Study |
| title_sort | trends in glycemia between 2002 and 2016 among incident youth cohorts early in the course of type 1 diabetes the search for diabetes in youth study |
| url | http://dx.doi.org/10.1155/2022/8554991 |
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