The dual effects of iron deficiency on intervertebral disc development and on acute injury-induced disc degeneration

The dual effects of iron deficiency on intervertebral disc development and on acute injury-induced disc degeneration

Abstract Clinical studies have reported that anemic patients with lower back pain exhibit significantly more severe lumbar intervertebral disc (IVD) degeneration compared to non-anemic individuals. Given that iron deficiency (ID) is the leading cause of anemia, we hypothesized that ID may disrupt IV...

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Bibliographic Details
Main Authors: Hengrui Chang, Shaomeng Kang, Chenchen Li, Lihui Wu, Hongran Liu, Di Zhang, Yanzhong Chang
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
Iron deficiency
Intervertebral disc degeneration
Anemia
Intervertebral disc development
Online Access:https://doi.org/10.1038/s41598-025-04388-4
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