Development, Characterization, and Pharmacodynamic Evaluation of Hydrochlorothiazide Loaded Self-Nanoemulsifying Drug Delivery Systems
The objective of the current work was to develop optimized self-nanoemulsifying drug delivery systems (SNEDDS) and evaluate their in vitro and in vivo performance. The research comprised various studies which includes solubility studies in various vehicles, pseudoternary phase diagram construction,...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2014/274823 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832556953721634816 |
|---|---|
| author | Pankajkumar S. Yadav Ekta Yadav Amita Verma Saima Amin |
| author_facet | Pankajkumar S. Yadav Ekta Yadav Amita Verma Saima Amin |
| author_sort | Pankajkumar S. Yadav |
| collection | DOAJ |
| description | The objective of the current work was to develop optimized self-nanoemulsifying drug delivery systems (SNEDDS) and evaluate their in vitro and in vivo performance. The research comprised various studies which includes solubility studies in various vehicles, pseudoternary phase diagram construction, and preparation and characterization of SNEDDS along with in vitro dissolution and in vivo pharmacodynamic profiling. Based on dissolution profile, a remarkable increase in rate of dissolution was observed in comparison with plain drug and marketed formulation. Optimized SNEDDS formulation was composed of Capmul MCM (19.17% w/w), Tween 80 (57.5% w/w), Transcutol P (12.7% w/w), and HCT (4.17% w/w). In vivo pharmacodynamic evaluation in Wistar rats showed considerable increase in pharmacological effect of HCT by SNEDDS formulation as compared with plain HCT. |
| format | Article |
| id | doaj-art-4d6cab74de674888bb194c85ce1a351d |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-4d6cab74de674888bb194c85ce1a351d2025-02-03T05:43:58ZengWileyThe Scientific World Journal2356-61401537-744X2014-01-01201410.1155/2014/274823274823Development, Characterization, and Pharmacodynamic Evaluation of Hydrochlorothiazide Loaded Self-Nanoemulsifying Drug Delivery SystemsPankajkumar S. Yadav0Ekta Yadav1Amita Verma2Saima Amin3Department of Pharmaceutical Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences (SHIATS), Allahabad 211 007, IndiaDepartment of Pharmaceutical Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences (SHIATS), Allahabad 211 007, IndiaDepartment of Pharmaceutical Sciences, Sam Higginbottom Institute of Agriculture, Technology & Sciences (SHIATS), Allahabad 211 007, IndiaDepartment of Pharmaceutics, Faculty of Pharmacy, Hamdard University, New Delhi 110 062, IndiaThe objective of the current work was to develop optimized self-nanoemulsifying drug delivery systems (SNEDDS) and evaluate their in vitro and in vivo performance. The research comprised various studies which includes solubility studies in various vehicles, pseudoternary phase diagram construction, and preparation and characterization of SNEDDS along with in vitro dissolution and in vivo pharmacodynamic profiling. Based on dissolution profile, a remarkable increase in rate of dissolution was observed in comparison with plain drug and marketed formulation. Optimized SNEDDS formulation was composed of Capmul MCM (19.17% w/w), Tween 80 (57.5% w/w), Transcutol P (12.7% w/w), and HCT (4.17% w/w). In vivo pharmacodynamic evaluation in Wistar rats showed considerable increase in pharmacological effect of HCT by SNEDDS formulation as compared with plain HCT.http://dx.doi.org/10.1155/2014/274823 |
| spellingShingle | Pankajkumar S. Yadav Ekta Yadav Amita Verma Saima Amin Development, Characterization, and Pharmacodynamic Evaluation of Hydrochlorothiazide Loaded Self-Nanoemulsifying Drug Delivery Systems The Scientific World Journal |
| title | Development, Characterization, and Pharmacodynamic Evaluation of Hydrochlorothiazide Loaded Self-Nanoemulsifying Drug Delivery Systems |
| title_full | Development, Characterization, and Pharmacodynamic Evaluation of Hydrochlorothiazide Loaded Self-Nanoemulsifying Drug Delivery Systems |
| title_fullStr | Development, Characterization, and Pharmacodynamic Evaluation of Hydrochlorothiazide Loaded Self-Nanoemulsifying Drug Delivery Systems |
| title_full_unstemmed | Development, Characterization, and Pharmacodynamic Evaluation of Hydrochlorothiazide Loaded Self-Nanoemulsifying Drug Delivery Systems |
| title_short | Development, Characterization, and Pharmacodynamic Evaluation of Hydrochlorothiazide Loaded Self-Nanoemulsifying Drug Delivery Systems |
| title_sort | development characterization and pharmacodynamic evaluation of hydrochlorothiazide loaded self nanoemulsifying drug delivery systems |
| url | http://dx.doi.org/10.1155/2014/274823 |
| work_keys_str_mv | AT pankajkumarsyadav developmentcharacterizationandpharmacodynamicevaluationofhydrochlorothiazideloadedselfnanoemulsifyingdrugdeliverysystems AT ektayadav developmentcharacterizationandpharmacodynamicevaluationofhydrochlorothiazideloadedselfnanoemulsifyingdrugdeliverysystems AT amitaverma developmentcharacterizationandpharmacodynamicevaluationofhydrochlorothiazideloadedselfnanoemulsifyingdrugdeliverysystems AT saimaamin developmentcharacterizationandpharmacodynamicevaluationofhydrochlorothiazideloadedselfnanoemulsifyingdrugdeliverysystems |